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    PUM2 pumilio RNA binding family member 2 [ Homo sapiens (human) ]

    Gene ID: 23369, updated on 25-Jan-2022

    Summary

    Official Symbol
    PUM2provided by HGNC
    Official Full Name
    pumilio RNA binding family member 2provided by HGNC
    Primary source
    HGNC:HGNC:14958
    See related
    Ensembl:ENSG00000055917 MIM:607205; AllianceGenome:HGNC:14958
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PUMH2; PUML2
    Summary
    This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PUM2 in Genome Data Viewer
    Location:
    2p24.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (20248691..20352253, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (20448452..20552014, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene DRG1 pseudogene 1 Neighboring gene RNA, U7 small nuclear 113 pseudogene Neighboring gene RP9, pre-mRNA splicing factor pseudogene Neighboring gene solute carrier family 7 member 15, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 86

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with pumilio homolog 2 (PUM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ36528, KIAA0235, MGC138251, MGC138253

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pumilio homolog 2
    Names
    pumilio-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282752.3NP_001269681.1  pumilio homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001269681.1

      Status: REVIEWED

      Source sequence(s)
      AC007041, AF315591, AK304198, BG717417
      Consensus CDS
      CCDS74487.1
      UniProtKB/Swiss-Prot
      Q8TB72
      Conserved Domains (1) summary
      cd07920
      Location:665986
      Pumilio; Pumilio-family RNA binding domain
    2. NM_001282790.2NP_001269719.1  pumilio homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001269719.1

      Status: REVIEWED

      Source sequence(s)
      AC007041, AF315591, BC143550, BX094307
      UniProtKB/TrEMBL
      B7ZL34
      Conserved Domains (1) summary
      cd07920
      Location:642963
      Pumilio; Pumilio-family RNA binding domain
    3. NM_001282791.2NP_001269720.1  pumilio homolog 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC007041, AF272350, AF315591, BC143552, BX094307
      Consensus CDS
      CCDS74486.1
      UniProtKB/TrEMBL
      A0A0A0MR59
      Related
      ENSP00000409905.1, ENST00000440577.5
      Conserved Domains (1) summary
      cd07920
      Location:586907
      Pumilio; Pumilio-family RNA binding domain
    4. NM_001352917.3NP_001339846.1  pumilio homolog 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Conserved Domains (1) summary
      cd07920
      Location:7211044
      Pumilio; Pumilio-family RNA binding domain
    5. NM_001352918.2NP_001339847.1  pumilio homolog 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Consensus CDS
      CCDS1698.1
      Conserved Domains (1) summary
      cd07920
      Location:7211042
      Pumilio; Pumilio-family RNA binding domain
    6. NM_001352919.3NP_001339848.1  pumilio homolog 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Consensus CDS
      CCDS1698.1
      Related
      ENSP00000338173.5, ENST00000338086.9
      Conserved Domains (1) summary
      cd07920
      Location:7211042
      Pumilio; Pumilio-family RNA binding domain
    7. NM_001352920.3NP_001339849.1  pumilio homolog 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Conserved Domains (1) summary
      cd07920
      Location:642965
      Pumilio; Pumilio-family RNA binding domain
    8. NM_001352923.3NP_001339852.1  pumilio homolog 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Conserved Domains (1) summary
      cd07920
      Location:642965
      Pumilio; Pumilio-family RNA binding domain
    9. NM_001352925.3NP_001339854.1  pumilio homolog 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Conserved Domains (1) summary
      cd07920
      Location:642963
      Pumilio; Pumilio-family RNA binding domain
    10. NM_001352926.2NP_001339855.1  pumilio homolog 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Conserved Domains (1) summary
      cd07920
      Location:642963
      Pumilio; Pumilio-family RNA binding domain
    11. NM_001352927.3NP_001339856.1  pumilio homolog 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Conserved Domains (1) summary
      cd07920
      Location:642963
      Pumilio; Pumilio-family RNA binding domain
    12. NM_001352928.3NP_001339857.1  pumilio homolog 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Conserved Domains (1) summary
      cd07920
      Location:642963
      Pumilio; Pumilio-family RNA binding domain
    13. NM_001352929.3NP_001339858.1  pumilio homolog 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Consensus CDS
      CCDS74486.1
      Conserved Domains (1) summary
      cd07920
      Location:586907
      Pumilio; Pumilio-family RNA binding domain
    14. NM_001352930.3NP_001339859.1  pumilio homolog 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Conserved Domains (1) summary
      cd07920
      Location:495816
      Pumilio; Pumilio-family RNA binding domain
    15. NM_015317.5NP_056132.1  pumilio homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_056132.1

      Status: REVIEWED

      Source sequence(s)
      AC007041, AF315591, AK093847, BG717417
      Consensus CDS
      CCDS1698.1
      UniProtKB/Swiss-Prot
      Q8TB72
      Related
      ENSP00000354370.4, ENST00000361078.7
      Conserved Domains (1) summary
      cd07920
      Location:7211042
      Pumilio; Pumilio-family RNA binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      20248691..20352253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711974.2XP_006712037.1  pumilio homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006712037.1

      UniProtKB/Swiss-Prot
      Q8TB72
      Conserved Domains (1) summary
      cd07920
      Location:7211044
      Pumilio; Pumilio-family RNA binding domain
    2. XM_017003715.1XP_016859204.1  pumilio homolog 2 isoform X5

    3. XM_011532723.1XP_011531025.1  pumilio homolog 2 isoform X4

      Conserved Domains (1) summary
      cd07920
      Location:495818
      Pumilio; Pumilio-family RNA binding domain
    4. XM_005262609.1XP_005262666.1  pumilio homolog 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8TB72
      Conserved Domains (1) summary
      cd07920
      Location:642965
      Pumilio; Pumilio-family RNA binding domain
    5. XM_005262607.1XP_005262664.1  pumilio homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_005262664.1

      UniProtKB/Swiss-Prot
      Q8TB72
      Conserved Domains (1) summary
      cd07920
      Location:7211044
      Pumilio; Pumilio-family RNA binding domain
    6. XM_011532721.2XP_011531023.1  pumilio homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011531023.1

      UniProtKB/Swiss-Prot
      Q8TB72
      Conserved Domains (1) summary
      cd07920
      Location:7211044
      Pumilio; Pumilio-family RNA binding domain
    7. XM_011532720.2XP_011531022.1  pumilio homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011531022.1

      UniProtKB/Swiss-Prot
      Q8TB72
      Conserved Domains (1) summary
      cd07920
      Location:7211044
      Pumilio; Pumilio-family RNA binding domain
    8. XM_011532719.1XP_011531021.1  pumilio homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011531021.1

      UniProtKB/Swiss-Prot
      Q8TB72
      Conserved Domains (1) summary
      cd07920
      Location:7211044
      Pumilio; Pumilio-family RNA binding domain
    9. XM_024452772.1XP_024308540.1  pumilio homolog 2 isoform X3

      Conserved Domains (1) summary
      cd07920
      Location:665988
      Pumilio; Pumilio-family RNA binding domain
    10. XM_024452773.1XP_024308541.1  pumilio homolog 2 isoform X8

      Conserved Domains (1) summary
      cd07920
      Location:258581
      Pumilio; Pumilio-family RNA binding domain
    11. XM_011532724.2XP_011531026.1  pumilio homolog 2 isoform X6

    12. XM_011532725.2XP_011531027.1  pumilio homolog 2 isoform X7

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