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    HAUS5 HAUS augmin like complex subunit 5 [ Homo sapiens (human) ]

    Gene ID: 23354, updated on 5-Mar-2024

    Summary

    Official Symbol
    HAUS5provided by HGNC
    Official Full Name
    HAUS augmin like complex subunit 5provided by HGNC
    Primary source
    HGNC:HGNC:29130
    See related
    Ensembl:ENSG00000249115 MIM:613432; AllianceGenome:HGNC:29130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dgt5; KIAA0841
    Summary
    HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
    Expression
    Ubiquitous expression in testis (RPKM 4.9), lymph node (RPKM 4.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    19q13.12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35612735..35625355)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38157682..38170309)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36103637..36116257)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1766 Neighboring gene HAUS5 divergent transcript Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:36103371-36103926 Neighboring gene tRNA-undetermined (NNN) 10-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:36118908-36119435 Neighboring gene Sharpr-MPRA regulatory region 5913 Neighboring gene RNA binding motif protein 42 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36132803-36133518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10531 Neighboring gene ETS variant transcription factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0841

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of microtubule nucleation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spindle assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of HAUS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of HAUS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of HAUS complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitotic spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    HAUS augmin-like complex subunit 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015302.2NP_056117.1  HAUS augmin-like complex subunit 5

      See identical proteins and their annotated locations for NP_056117.1

      Status: VALIDATED

      Source sequence(s)
      AB020648, AC002115, BC064390
      Consensus CDS
      CCDS42550.1
      UniProtKB/Swiss-Prot
      B2RXK1, O94927, Q6P2P7, Q7L3D5, Q96CT8
      Related
      ENSP00000439056.1, ENST00000203166.10
      Conserved Domains (1) summary
      pfam14817
      Location:7619
      HAUS5; HAUS augmin-like complex subunit 5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35612735..35625355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438524.1XP_047294480.1  HAUS augmin-like complex subunit 5 isoform X1

    2. XM_047438525.1XP_047294481.1  HAUS augmin-like complex subunit 5 isoform X3

      Related
      ENSP00000466661.1, ENST00000587439.5
    3. XM_011526684.3XP_011524986.1  HAUS augmin-like complex subunit 5 isoform X2

      See identical proteins and their annotated locations for XP_011524986.1

      Conserved Domains (1) summary
      pfam14817
      Location:1519
      HAUS5; HAUS augmin-like complex subunit 5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38157682..38170309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320369.1XP_054176344.1  HAUS augmin-like complex subunit 5 isoform X1

    2. XM_054320371.1XP_054176346.1  HAUS augmin-like complex subunit 5 isoform X3

    3. XM_054320370.1XP_054176345.1  HAUS augmin-like complex subunit 5 isoform X2