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    Picalm phosphatidylinositol binding clathrin assembly protein [ Mus musculus (house mouse) ]

    Gene ID: 233489, updated on 5-Sep-2021

    Summary

    Official Symbol
    Picalmprovided by MGI
    Official Full Name
    phosphatidylinositol binding clathrin assembly proteinprovided by MGI
    Primary source
    MGI:MGI:2385902
    See related
    Ensembl:ENSMUSG00000039361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    fit; CALM; CLTH; fit-; fit1; fit-1; PAP180; mKIAA4114
    Expression
    Ubiquitous expression in liver E14 (RPKM 62.1), liver E14.5 (RPKM 55.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Picalm in Genome Data Viewer
    Location:
    7 D3; 7 50.47 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89779418..89858655)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (90130192..90209447)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (97278742..97357442)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310010J17 gene Neighboring gene basic transcription factor 3, pseudogene 5 Neighboring gene coiled-coil domain containing 83 Neighboring gene synaptotagmin-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4114, MGC19382, MGC36413, MGC36616

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables clathrin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance by transcytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in amyloid-beta clearance by transcytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amyloid-beta clearance by transcytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin-coated pit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning or memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in membrane bending ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of age-related behavioral decline IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of amyloid-beta formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic vesicle clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in regulation of amyloid-beta formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of terminal button organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vesicle size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle budding from membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle cargo loading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    part_of clathrin coat of coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome to plasma membrane transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neurofibrillary tangle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylinositol-binding clathrin assembly protein
    Names
    clathrin assembly lymphoid myeloid leukemia

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252520.2NP_001239449.1  phosphatidylinositol-binding clathrin assembly protein isoform 2

      See identical proteins and their annotated locations for NP_001239449.1

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, AK220291, BK001028
      Consensus CDS
      CCDS85335.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      UniProtKB/TrEMBL
      Q570Z8
      Related
      ENSMUSP00000051092.9, ENSMUST00000049537.9
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    2. NM_001252521.2NP_001239450.1  phosphatidylinositol-binding clathrin assembly protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, AK220291, BK001028
      Consensus CDS
      CCDS85334.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      UniProtKB/TrEMBL
      Q570Z8
      Related
      ENSMUSP00000147016.2, ENSMUST00000208742.2
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    3. NM_001252522.2NP_001239451.1  phosphatidylinositol-binding clathrin assembly protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, AK220291, BK001028
      Consensus CDS
      CCDS85336.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      UniProtKB/TrEMBL
      Q570Z8
      Related
      ENSMUSP00000146386.2, ENSMUST00000209068.2
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    4. NM_001252523.2NP_001239452.1  phosphatidylinositol-binding clathrin assembly protein isoform 5

      See identical proteins and their annotated locations for NP_001239452.1

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, AK220291, BK001028
      Consensus CDS
      CCDS85337.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      UniProtKB/TrEMBL
      Q570Z8
      Related
      ENSMUSP00000146541.2, ENSMUST00000208730.2
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    5. NM_001252524.2NP_001239453.1  phosphatidylinositol-binding clathrin assembly protein isoform 6

      See identical proteins and their annotated locations for NP_001239453.1

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, AK220291, BK001028
      Consensus CDS
      CCDS85338.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      UniProtKB/TrEMBL
      Q3TD51, Q570Z8
      Related
      ENSMUSP00000146659.2, ENSMUST00000207225.2
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    6. NM_001360867.1NP_001347796.1  phosphatidylinositol-binding clathrin assembly protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781
      Conserved Domains (2) summary
      COG4223
      Location:268366
      COG4223; Uncharacterized conserved protein [Function unknown]
      pfam07651
      Location:24282
      ANTH; ANTH domain
    7. NM_146194.5NP_666306.2  phosphatidylinositol-binding clathrin assembly protein isoform 1

      See identical proteins and their annotated locations for NP_666306.2

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, BK001028, BY160265
      Consensus CDS
      CCDS52307.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      Related
      ENSMUSP00000146501.2, ENSMUST00000207484.2
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      89779418..89858655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507594.5XP_006507657.1  phosphatidylinositol-binding clathrin assembly protein isoform X1

      Conserved Domains (1) summary
      pfam07651
      Location:24283
      ANTH; ANTH domain
    2. XM_006507597.5XP_006507660.1  phosphatidylinositol-binding clathrin assembly protein isoform X4

      Conserved Domains (1) summary
      pfam07651
      Location:24283
      ANTH; ANTH domain
    3. XM_006507595.5XP_006507658.1  phosphatidylinositol-binding clathrin assembly protein isoform X2

      Conserved Domains (1) summary
      pfam07651
      Location:24283
      ANTH; ANTH domain
    4. XM_006507598.5XP_006507661.1  phosphatidylinositol-binding clathrin assembly protein isoform X5

      Conserved Domains (1) summary
      pfam07651
      Location:24283
      ANTH; ANTH domain
    5. XM_006507596.5XP_006507659.1  phosphatidylinositol-binding clathrin assembly protein isoform X3

      Conserved Domains (1) summary
      pfam07651
      Location:24283
      ANTH; ANTH domain
    6. XM_006507599.5XP_006507662.1  phosphatidylinositol-binding clathrin assembly protein isoform X6

      Conserved Domains (1) summary
      pfam07651
      Location:24283
      ANTH; ANTH domain
    7. XM_030242474.2XP_030098334.1  phosphatidylinositol-binding clathrin assembly protein isoform X8

      Conserved Domains (1) summary
      pfam07651
      Location:24283
      ANTH; ANTH domain
    8. XM_006507600.5XP_006507663.1  phosphatidylinositol-binding clathrin assembly protein isoform X7

      Conserved Domains (1) summary
      pfam07651
      Location:24283
      ANTH; ANTH domain
    9. XM_030242475.2XP_030098335.1  phosphatidylinositol-binding clathrin assembly protein isoform X9

      Related
      ENSMUSP00000146509.2, ENSMUST00000207084.2
      Conserved Domains (1) summary
      pfam07651
      Location:24283
      ANTH; ANTH domain
    10. XM_006507602.5XP_006507665.1  phosphatidylinositol-binding clathrin assembly protein isoform X10

      Conserved Domains (2) summary
      COG4223
      Location:268366
      COG4223; Uncharacterized conserved protein [Function unknown]
      pfam07651
      Location:24283
      ANTH; ANTH domain
    11. XM_006507604.5XP_006507667.1  phosphatidylinositol-binding clathrin assembly protein isoform X12

      Conserved Domains (2) summary
      COG4223
      Location:268366
      COG4223; Uncharacterized conserved protein [Function unknown]
      pfam07651
      Location:24283
      ANTH; ANTH domain
    12. XM_030242476.2XP_030098336.1  phosphatidylinositol-binding clathrin assembly protein isoform X14

      Conserved Domains (2) summary
      COG4223
      Location:268366
      COG4223; Uncharacterized conserved protein [Function unknown]
      pfam07651
      Location:24283
      ANTH; ANTH domain
    13. XM_006507603.5XP_006507666.1  phosphatidylinositol-binding clathrin assembly protein isoform X11

      Conserved Domains (2) summary
      COG4223
      Location:268366
      COG4223; Uncharacterized conserved protein [Function unknown]
      pfam07651
      Location:24283
      ANTH; ANTH domain
    14. XM_006507605.5XP_006507668.1  phosphatidylinositol-binding clathrin assembly protein isoform X13

      Conserved Domains (2) summary
      COG4223
      Location:268366
      COG4223; Uncharacterized conserved protein [Function unknown]
      pfam07651
      Location:24283
      ANTH; ANTH domain
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