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    Picalm phosphatidylinositol binding clathrin assembly protein [ Mus musculus (house mouse) ]

    Gene ID: 233489, updated on 2-Oct-2018

    Summary

    Official Symbol
    Picalmprovided by MGI
    Official Full Name
    phosphatidylinositol binding clathrin assembly proteinprovided by MGI
    Primary source
    MGI:MGI:2385902
    See related
    Ensembl:ENSMUSG00000039361 Vega:OTTMUSG00000059751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CALM; CLTH; fit1; fit-1; PAP180; mKIAA4114
    Expression
    Ubiquitous expression in liver E14 (RPKM 62.1), liver E14.5 (RPKM 55.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Picalm in Genome Data Viewer
    Location:
    7 D3-E1; 7 50.47 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (90130220..90209447)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (97278742..97357442)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310010J17 gene Neighboring gene basic transcription factor 3 pseudogene Neighboring gene coiled-coil domain containing 83 Neighboring gene synaptotagmin-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4114, MGC19382, MGC36413, MGC36616

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cargo loading into vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cargo loading into vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    endosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    learning or memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    membrane bending ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of age-related behavioral decline IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of amyloid-beta clearance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of amyloid-beta clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of amyloid-beta formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic vesicle clustering ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    NOT regulation of amyloid-beta formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of terminal button organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of vesicle size ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcytosis ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle budding from membrane ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with AP-2 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with clathrin coat of coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome to plasma membrane transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of presynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neurofibrillary tangle ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylinositol-binding clathrin assembly protein
    Names
    clathrin assembly lymphoid myeloid leukemia

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252520.2NP_001239449.1  phosphatidylinositol-binding clathrin assembly protein isoform 2

      See identical proteins and their annotated locations for NP_001239449.1

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, AK220291, BK001028
      Consensus CDS
      CCDS85335.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      UniProtKB/TrEMBL
      Q570Z8
      Related
      ENSMUSP00000051092.8, OTTMUSP00000076261, ENSMUST00000049537.8
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    2. NM_001252521.2NP_001239450.1  phosphatidylinositol-binding clathrin assembly protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, AK220291, BK001028
      Consensus CDS
      CCDS85334.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      UniProtKB/TrEMBL
      Q570Z8
      Related
      ENSMUSP00000147016.1, OTTMUSP00000076260, ENSMUST00000208742.1
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    3. NM_001252522.2NP_001239451.1  phosphatidylinositol-binding clathrin assembly protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, AK220291, BK001028
      Consensus CDS
      CCDS85336.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      UniProtKB/TrEMBL
      Q570Z8
      Related
      ENSMUSP00000146386.1, OTTMUSP00000076258, ENSMUST00000209068.1
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    4. NM_001252523.2NP_001239452.1  phosphatidylinositol-binding clathrin assembly protein isoform 5

      See identical proteins and their annotated locations for NP_001239452.1

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, AK220291, BK001028
      Consensus CDS
      CCDS85337.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      UniProtKB/TrEMBL
      Q570Z8
      Related
      ENSMUSP00000146541.1, OTTMUSP00000076259, ENSMUST00000208730.1
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    5. NM_001252524.2NP_001239453.1  phosphatidylinositol-binding clathrin assembly protein isoform 6

      See identical proteins and their annotated locations for NP_001239453.1

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, AK220291, BK001028
      Consensus CDS
      CCDS85338.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      UniProtKB/TrEMBL
      Q3TD51, Q570Z8
      Related
      ENSMUSP00000146659.1, OTTMUSP00000076256, ENSMUST00000207225.1
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    6. NM_001360867.1NP_001347796.1  phosphatidylinositol-binding clathrin assembly protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781
      Conserved Domains (2) summary
      COG4223
      Location:268366
      COG4223; Uncharacterized conserved protein [Function unknown]
      pfam07651
      Location:24282
      ANTH; ANTH domain
    7. NM_146194.5NP_666306.2  phosphatidylinositol-binding clathrin assembly protein isoform 1

      See identical proteins and their annotated locations for NP_666306.2

      Status: VALIDATED

      Source sequence(s)
      AC130210, AC158781, BK001028, BY160265
      Consensus CDS
      CCDS52307.1
      UniProtKB/Swiss-Prot
      Q7M6Y3
      Related
      ENSMUSP00000146501.1, OTTMUSP00000076257, ENSMUST00000207484.1
      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      90130220..90209447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507594.3XP_006507657.1  phosphatidylinositol-binding clathrin assembly protein isoform X1

      Conserved Domains (3) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
      pfam11029
      Location:578659
      DAZAP2; DAZ associated protein 2 (DAZAP2)
    2. XM_006507597.3XP_006507660.1  phosphatidylinositol-binding clathrin assembly protein isoform X4

      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    3. XM_006507595.3XP_006507658.1  phosphatidylinositol-binding clathrin assembly protein isoform X2

      Conserved Domains (3) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
      pfam11029
      Location:573654
      DAZAP2; DAZ associated protein 2 (DAZAP2)
    4. XM_006507598.3XP_006507661.1  phosphatidylinositol-binding clathrin assembly protein isoform X5

      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    5. XM_006507601.3XP_006507664.1  phosphatidylinositol-binding clathrin assembly protein isoform X8

      Related
      ENSMUSP00000146509.1, OTTMUSP00000076263, ENSMUST00000207084.1, OTTMUST00000146475
      Conserved Domains (2) summary
      COG4223
      Location:268366
      COG4223; Uncharacterized conserved protein [Function unknown]
      pfam07651
      Location:24282
      ANTH; ANTH domain
    6. XM_006507596.3XP_006507659.1  phosphatidylinositol-binding clathrin assembly protein isoform X3

      Conserved Domains (3) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
      pfam11029
      Location:571652
      DAZAP2; DAZ associated protein 2 (DAZAP2)
    7. XM_006507599.3XP_006507662.1  phosphatidylinositol-binding clathrin assembly protein isoform X6

      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    8. XM_006507600.3XP_006507663.1  phosphatidylinositol-binding clathrin assembly protein isoform X7

      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    9. XM_006507602.3XP_006507665.1  phosphatidylinositol-binding clathrin assembly protein isoform X9

      Conserved Domains (3) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
      pfam11029
      Location:528609
      DAZAP2; DAZ associated protein 2 (DAZAP2)
    10. XM_006507604.3XP_006507667.1  phosphatidylinositol-binding clathrin assembly protein isoform X11

      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
    11. XM_006507603.3XP_006507666.1  phosphatidylinositol-binding clathrin assembly protein isoform X10

      Conserved Domains (3) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
      pfam11029
      Location:523604
      DAZAP2; DAZ associated protein 2 (DAZAP2)
    12. XM_006507605.3XP_006507668.1  phosphatidylinositol-binding clathrin assembly protein isoform X12

      Conserved Domains (2) summary
      pfam07651
      Location:19282
      ANTH; ANTH domain
      pfam08287
      Location:265344
      DASH_Spc19; Spc19
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