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    USP22 ubiquitin specific peptidase 22 [ Homo sapiens (human) ]

    Gene ID: 23326, updated on 13-Apr-2024

    Summary

    Official Symbol
    USP22provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 22provided by HGNC
    Primary source
    HGNC:HGNC:12621
    See related
    Ensembl:ENSG00000124422 MIM:612116; AllianceGenome:HGNC:12621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USP3L
    Summary
    Enables enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent deubiquitinase. Contributes to H4 histone acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 54.0), ovary (RPKM 38.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See USP22 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (20999596..21043419, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (20948437..20992181, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (20902909..20946324, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CCDC144NL antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20811295-20811890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8310 Neighboring gene ribonuclease H1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20841589-20842090 Neighboring gene uncharacterized LOC124900389 Neighboring gene Sharpr-MPRA regulatory region 15661 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:20845395-20845894 Neighboring gene uncharacterized LOC339260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11876 Neighboring gene SPECC1 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20901079-20901896 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:20937215-20937716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20946145-20947094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20947095-20948042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20954728-20955314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11877 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20970211-20970711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20978550-20979050 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:20987896-20989095 Neighboring gene long intergenic non-protein coding RNA 1563 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:21002173-21002789 and GRCh37_chr17:21002790-21003407 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:21011664-21012527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11879 Neighboring gene dehydrogenase/reductase 7B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1063

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 22
    Names
    deubiquitinating enzyme 22
    ubiquitin specific protease 22
    ubiquitin thioesterase 22
    ubiquitin thiolesterase 22
    ubiquitin-specific processing protease 22
    NP_056091.1
    XP_005256632.1
    XP_047291659.1
    XP_054171598.1
    XP_054171599.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015276.2NP_056091.1  ubiquitin carboxyl-terminal hydrolase 22

      See identical proteins and their annotated locations for NP_056091.1

      Status: VALIDATED

      Source sequence(s)
      AB028986, AL110213, BX640815
      Consensus CDS
      CCDS42285.1
      UniProtKB/Swiss-Prot
      A0JNS3, Q2NLE2, Q6MZY4, Q8TBS8, Q96IW5, Q9UPT9
      Related
      ENSP00000261497.4, ENST00000261497.9
      Conserved Domains (2) summary
      cd02660
      Location:176518
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:63123
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      20999596..21043419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256575.3XP_005256632.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

      See identical proteins and their annotated locations for XP_005256632.1

      Conserved Domains (2) summary
      cd02660
      Location:71413
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:70412
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. XM_047435703.1XP_047291659.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      20948437..20992181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315623.1XP_054171598.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

    2. XM_054315624.1XP_054171599.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1