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    WSCD1 WSC domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 23302, updated on 21-May-2024

    Summary

    Official Symbol
    WSCD1provided by HGNC
    Official Full Name
    WSC domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:29060
    See related
    Ensembl:ENSG00000179314 MIM:619584; AllianceGenome:HGNC:29060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable sulfotransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 6.9), spleen (RPKM 4.6) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See WSCD1 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (6069116..6124427)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (5963314..6018611)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (5972436..6027747)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene nipsnap homolog 1 (C. elegans) pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:5635830-5637029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11583 Neighboring gene uncharacterized LOC339166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:5740831-5741332 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:5800477-5801376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:5801377-5802275 Neighboring gene NANOG hESC enhancer GRCh37_chr17:5816130-5816781 Neighboring gene Sharpr-MPRA regulatory region 3217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:5972935-5973766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:5983596-5984097 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:5990226-5990917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:5999248-6000148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:6000149-6001047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:6001681-6002448 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:6011648-6011820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6038771-6039272 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:6042463-6043017 Neighboring gene uncharacterized LOC105371508 Neighboring gene Sharpr-MPRA regulatory region 13257 Neighboring gene RNA, U6 small nuclear 1264, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of WSC domain containing 1 (WSCD1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    General gene information

    Markers

    Clone Names

    • KIAA0523

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    sialate:O-sulfotransferase 1
    Names
    WSC domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388405.1NP_001375334.1  sialate:O-sulfotransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC001231, AC104770
      Consensus CDS
      CCDS32538.1
      UniProtKB/Swiss-Prot
      A8K0N8, D3DTM3, O60276, Q658N2, Q96G45
      Related
      ENSP00000460825.1, ENST00000574946.5
      Conserved Domains (2) summary
      smart00321
      Location:142234
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:425517
      Sulfotransfer_3; Sulfotransferase family
    2. NM_001388406.1NP_001375335.1  sialate:O-sulfotransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC001231, AC104770
      Consensus CDS
      CCDS32538.1
      UniProtKB/Swiss-Prot
      A8K0N8, D3DTM3, O60276, Q658N2, Q96G45
      Related
      ENSP00000458374.1, ENST00000574232.5
      Conserved Domains (2) summary
      smart00321
      Location:142234
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:425517
      Sulfotransfer_3; Sulfotransferase family
    3. NM_001388407.1NP_001375336.1  sialate:O-sulfotransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC001231, AC104770
      Consensus CDS
      CCDS32538.1
      UniProtKB/Swiss-Prot
      A8K0N8, D3DTM3, O60276, Q658N2, Q96G45
      Conserved Domains (2) summary
      smart00321
      Location:142234
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:425517
      Sulfotransfer_3; Sulfotransferase family
    4. NM_001388408.1NP_001375337.1  sialate:O-sulfotransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC001231, AC104770
      UniProtKB/TrEMBL
      I3L3E6
      Related
      ENSP00000460396.1, ENST00000573634.5
      Conserved Domains (2) summary
      smart00321
      Location:77172
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:257349
      Sulfotransfer_3; Sulfotransferase family
    5. NM_001388409.1NP_001375338.1  sialate:O-sulfotransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC001231, AC104770
      UniProtKB/TrEMBL
      I3L3E6
      Conserved Domains (2) summary
      smart00321
      Location:77172
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:257349
      Sulfotransfer_3; Sulfotransferase family
    6. NM_001388410.1NP_001375339.1  sialate:O-sulfotransferase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104770
      Conserved Domains (2) summary
      smart00321
      Location:142234
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl02568
      Location:245287
      WSC; WSC domain
    7. NM_001388411.1NP_001375340.1  sialate:O-sulfotransferase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC001231, AC104770
      Conserved Domains (2) summary
      smart00321
      Location:142234
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl02568
      Location:245287
      WSC; WSC domain
    8. NM_015253.2NP_056068.1  sialate:O-sulfotransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_056068.1

      Status: VALIDATED

      Source sequence(s)
      AC001231, AC104770, AL833730, BC009975, BE504506
      Consensus CDS
      CCDS32538.1
      UniProtKB/Swiss-Prot
      A8K0N8, D3DTM3, O60276, Q658N2, Q96G45
      Related
      ENSP00000323087.5, ENST00000317744.10
      Conserved Domains (2) summary
      smart00321
      Location:142234
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:425517
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      6069116..6124427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435701.1XP_047291657.1  sialate:O-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0N8, D3DTM3, O60276, Q658N2, Q96G45
    2. XM_047435702.1XP_047291658.1  sialate:O-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0N8, D3DTM3, O60276, Q658N2, Q96G45
      Related
      ENSP00000519350.1, ENST00000714060.1
    3. XM_005256572.2XP_005256629.1  sialate:O-sulfotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_005256629.1

      UniProtKB/Swiss-Prot
      A8K0N8, D3DTM3, O60276, Q658N2, Q96G45
      Related
      ENSP00000458527.2, ENST00000571973.2
      Conserved Domains (2) summary
      smart00321
      Location:142234
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:425517
      Sulfotransfer_3; Sulfotransferase family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      5963314..6018611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315621.1XP_054171596.1  sialate:O-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0N8, D3DTM3, O60276, Q658N2, Q96G45
    2. XM_054315622.1XP_054171597.1  sialate:O-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0N8, D3DTM3, O60276, Q658N2, Q96G45
    3. XM_054315620.1XP_054171595.1  sialate:O-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0N8, D3DTM3, O60276, Q658N2, Q96G45