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    Mark4 MAP/microtubule affinity regulating kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 232944, updated on 9-Sep-2018

    Summary

    Official Symbol
    Mark4provided by MGI
    Official Full Name
    MAP/microtubule affinity regulating kinase 4provided by MGI
    Primary source
    MGI:MGI:1920955
    See related
    Ensembl:ENSMUSG00000030397 Vega:OTTMUSG00000059238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C79806; Markl1; 2410090P21Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 24.4), ovary adult (RPKM 18.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mark4 in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (19425102..19458797, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (20011424..20043843, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38954 Neighboring gene RIKEN cDNA A930016O22 gene Neighboring gene creatine kinase, muscle Neighboring gene exocyst complex component 3-like 2 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    cilium organization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    gamma-tubulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    MAP/microtubule affinity-regulating kinase 4
    Names
    MAP/microtubule affinity-regulating kinase 4L
    MARK4 serine/threonine protein kinase
    NP_758483.1
    XP_006539892.1
    XP_011248815.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172279.1NP_758483.1  MAP/microtubule affinity-regulating kinase 4

      See identical proteins and their annotated locations for NP_758483.1

      Status: PROVISIONAL

      Source sequence(s)
      AY151083
      Consensus CDS
      CCDS20903.1
      UniProtKB/Swiss-Prot
      Q8CIP4
      Related
      ENSMUSP00000082862.5, OTTMUSP00000075743, ENSMUST00000085715.6, OTTMUST00000145367
      Conserved Domains (4) summary
      cd12197
      Location:654752
      MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
      smart00220
      Location:59310
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:328370
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:58310
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      19425102..19458797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539829.3XP_006539892.1  MAP/microtubule affinity-regulating kinase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8CIP4
      Conserved Domains (3) summary
      smart00220
      Location:59310
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:328370
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:58310
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. XM_011250513.2XP_011248815.1  MAP/microtubule affinity-regulating kinase 4 isoform X2

      Conserved Domains (4) summary
      cd12197
      Location:545643
      MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
      smart00220
      Location:1201
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:219261
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cl21453
      Location:1201
      PKc_like; Protein Kinases, catalytic domain
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