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    Ap2s1 adaptor-related protein complex 2, sigma 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 232910, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ap2s1provided by MGI
    Official Full Name
    adaptor-related protein complex 2, sigma 1 subunitprovided by MGI
    Primary source
    MGI:MGI:2141861
    See related
    Ensembl:ENSMUSG00000008036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI043088
    Expression
    Ubiquitous expression in duodenum adult (RPKM 68.3), large intestine adult (RPKM 65.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ap2s1 in Genome Data Viewer
    Location:
    7; 7 A2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16472369..16483215)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16738444..16749290)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (17323793..17334639)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 9 Neighboring gene solute carrier family 1 (neutral amino acid transporter), member 5 Neighboring gene fukutin related protein Neighboring gene striatin, calmodulin binding protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC62945

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of AP-2 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    AP-2 complex subunit sigma
    Names
    adapter-related protein complex 2 sigma subunit
    adapter-related protein complex 2 subunit sigma
    adaptor protein complex AP-2 subunit sigma
    adaptor-related protein complex 2 subunit sigma
    clathrin assembly protein 2 sigma small chain
    clathrin assembly protein 2 small chain
    clathrin coat assembly protein AP17
    clathrin coat-associated protein AP17
    plasma membrane adaptor AP-2 17 kDa protein
    sigma-adaptin 3b
    sigma2-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198613.2NP_941015.2  AP-2 complex subunit sigma

      See identical proteins and their annotated locations for NP_941015.2

      Status: VALIDATED

      Source sequence(s)
      AK146584
      Consensus CDS
      CCDS52042.1
      UniProtKB/Swiss-Prot
      P62743
      UniProtKB/TrEMBL
      Q3UJ76
      Related
      ENSMUSP00000083281.7, ENSMUST00000086112.8
      Conserved Domains (1) summary
      cd14833
      Location:1141
      AP2_sigma; AP-2 complex subunit sigma

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      16472369..16483215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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