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    Arhgap35 Rho GTPase activating protein 35 [ Mus musculus (house mouse) ]

    Gene ID: 232906, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arhgap35provided by MGI
    Official Full Name
    Rho GTPase activating protein 35provided by MGI
    Primary source
    MGI:MGI:1929494
    See related
    Ensembl:ENSMUSG00000058230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grlf1; p190A; AI841135; mKIAA1722; p190RhoGAP; 6430596G11Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 20.1), ovary adult (RPKM 18.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Arhgap35 in Genome Data Viewer
    Location:
    7; 7 A2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (16494473..16615244, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (17079822..17200342, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 160 Neighboring gene neuronal PAS domain protein 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 17981 Neighboring gene predicted gene 29443 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule pseudogene 1 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1722

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to extracellular stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of actin cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Rho protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of actin polymerization or depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing, spreading of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 35
    Names
    P190 RhoGAP
    glucocorticoid receptor DNA-binding factor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172739.4NP_766327.3  rho GTPase-activating protein 35

      See identical proteins and their annotated locations for NP_766327.3

      Status: VALIDATED

      Source sequence(s)
      AK032559, AK136766, AK137250, AK147326
      Consensus CDS
      CCDS20851.1
      UniProtKB/Swiss-Prot
      Q91YM2
      UniProtKB/TrEMBL
      B2RTN5, Q3UVZ8, Q8CCL8
      Related
      ENSMUSP00000075242.4, ENSMUST00000075845.10
      Conserved Domains (4) summary
      smart00441
      Location:431483
      FF; Contains two conserved F residues
      cd04373
      Location:12471431
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam16512
      Location:261340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl27030
      Location:158250
      Ras; Ras family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      16494473..16615244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539809.3XP_006539872.1  rho GTPase-activating protein 35 isoform X1

      See identical proteins and their annotated locations for XP_006539872.1

      UniProtKB/Swiss-Prot
      Q91YM2
      UniProtKB/TrEMBL
      B2RTN5
      Conserved Domains (4) summary
      smart00441
      Location:431483
      FF; Contains two conserved F residues
      cd04373
      Location:12471431
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam16512
      Location:261340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl27030
      Location:158250
      Ras; Ras family
    2. XM_011250512.2XP_011248814.1  rho GTPase-activating protein 35 isoform X1

      See identical proteins and their annotated locations for XP_011248814.1

      UniProtKB/Swiss-Prot
      Q91YM2
      UniProtKB/TrEMBL
      B2RTN5
      Conserved Domains (4) summary
      smart00441
      Location:431483
      FF; Contains two conserved F residues
      cd04373
      Location:12471431
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam16512
      Location:261340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl27030
      Location:158250
      Ras; Ras family
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