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    Pla2g4c phospholipase A2, group IVC (cytosolic, calcium-independent) [ Mus musculus (house mouse) ]

    Gene ID: 232889, updated on 16-Oct-2021

    Summary

    Official Symbol
    Pla2g4cprovided by MGI
    Official Full Name
    phospholipase A2, group IVC (cytosolic, calcium-independent)provided by MGI
    Primary source
    MGI:MGI:1196403
    See related
    Ensembl:ENSMUSG00000033847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D7Ertd445e
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pla2g4c in Genome Data Viewer
    Location:
    7 A1; 7 7.84 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (13045432..13094597)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13311507..13360674)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (13911016..13946017)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 69 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene ligase I, DNA, ATP-dependent Neighboring gene ribosomal protein S8, pseudogene 4 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent), pseudogene Neighboring gene calcium binding protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidyl phospholipase B activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glycerophospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylcholine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylethanolamine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet activating factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytosolic phospholipase A2 gamma
    Names
    CPLA2-gamma
    cytosolic lysophospholipase
    cytosolic lysophospholipid O-acyltransferase
    egg and early embryo abundant protein
    NP_001004762.1
    NP_001161976.1
    XP_006539868.1
    XP_036008837.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004762.3NP_001004762.1  cytosolic phospholipase A2 gamma isoform 2

      See identical proteins and their annotated locations for NP_001004762.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC161792, AK136098
      Consensus CDS
      CCDS39771.1
      UniProtKB/Swiss-Prot
      Q64GA5
      Related
      ENSMUSP00000043672.10, ENSMUST00000043612.10
      Conserved Domains (1) summary
      cd07202
      Location:5561
      cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
    2. NM_001168504.1NP_001161976.1  cytosolic phospholipase A2 gamma isoform 1

      See identical proteins and their annotated locations for NP_001161976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161792, BC117808
      Consensus CDS
      CCDS52027.1
      UniProtKB/Swiss-Prot
      Q64GA5
      Related
      ENSMUSP00000104168.3, ENSMUST00000108528.9
      Conserved Domains (1) summary
      cd07202
      Location:15571
      cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      13045432..13094597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152944.1XP_036008837.1  cytosolic phospholipase A2 gamma isoform X1

      Conserved Domains (1) summary
      cd07202
      Location:97653
      cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
    2. XM_006539805.3XP_006539868.1  cytosolic phospholipase A2 gamma isoform X1

      Conserved Domains (1) summary
      cd07202
      Location:97653
      cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
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