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    AGTPBP1 ATP/GTP binding carboxypeptidase 1 [ Homo sapiens (human) ]

    Gene ID: 23287, updated on 28-Oct-2024

    Summary

    Official Symbol
    AGTPBP1provided by HGNC
    Official Full Name
    ATP/GTP binding carboxypeptidase 1provided by HGNC
    Primary source
    HGNC:HGNC:17258
    See related
    Ensembl:ENSG00000135049 MIM:606830; AllianceGenome:HGNC:17258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCP1; NNA1; CONDCA
    Summary
    NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]
    Expression
    Broad expression in bone marrow (RPKM 7.2), brain (RPKM 4.8) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AGTPBP1 in Genome Data Viewer
    Location:
    9q21.33
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (85546539..85805483, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (97697026..97955976, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88161454..88356944, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 33 pseudogene 1 Neighboring gene uncharacterized LOC101927603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88215278-88216090 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88337736-88338412 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88338413-88339088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28513 Neighboring gene kinesin family member 27 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19990 Neighboring gene NANOG hESC enhancer GRCh37_chr9:88433900-88434401 Neighboring gene kinesin family member 27 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:88494220-88494782 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:88513172-88514371 Neighboring gene PHB1 pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1035, DKFZp686M20191

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallocarboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metallocarboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in C-terminal protein deglutamylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in C-terminal protein deglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterograde axonal transport of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebellar Purkinje cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in eye photoreceptor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuromuscular process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in olfactory bulb development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein deglutamylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein side chain deglutamylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein side chain deglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde axonal transport of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytosolic carboxypeptidase 1
    Names
    ATP/GTP binding protein 1
    carboxypeptidase-tubulin
    nervous system nuclear protein induced by axotomy protein 1 homolog
    protein deglutamylase CCP1
    soluble carboxypeptidase
    tubulinyl-Tyr carboxypeptidase
    tyrosine carboxypeptidase
    NP_001273644.1
    NP_001273646.1
    NP_001317630.1
    NP_056054.2
    XP_005251905.1
    XP_011516720.1
    XP_011516722.1
    XP_011516723.1
    XP_016870034.1
    XP_047279042.1
    XP_047279043.1
    XP_047279044.1
    XP_047279045.1
    XP_047279046.1
    XP_047279047.1
    XP_047279048.1
    XP_047279049.1
    XP_047279050.1
    XP_047279051.1
    XP_047279052.1
    XP_047279053.1
    XP_047279054.1
    XP_047279055.1
    XP_047279056.1
    XP_047279057.1
    XP_054218489.1
    XP_054218490.1
    XP_054218491.1
    XP_054218492.1
    XP_054218493.1
    XP_054218494.1
    XP_054218495.1
    XP_054218496.1
    XP_054218497.1
    XP_054218498.1
    XP_054218499.1
    XP_054218500.1
    XP_054218501.1
    XP_054218502.1
    XP_054218503.1
    XP_054218504.1
    XP_054218505.1
    XP_054218506.1
    XP_054218507.1
    XP_054218508.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286715.1NP_001273644.1  cytosolic carboxypeptidase 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB028958, AK295774, CA449535
      Consensus CDS
      CCDS75854.1
      UniProtKB/TrEMBL
      J3KNS1
      Related
      ENSP00000338512.5, ENST00000337006.8
      Conserved Domains (1) summary
      cd06906
      Location:9111188
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    2. NM_001286717.1NP_001273646.1  cytosolic carboxypeptidase 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AK295774, AL157882, AL451131, CA449535
      Consensus CDS
      CCDS69615.1
      UniProtKB/Swiss-Prot
      Q9UPW5
      Related
      ENSP00000487074.1, ENST00000628899.1
      Conserved Domains (1) summary
      cd06906
      Location:8711148
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    3. NM_001330701.2NP_001317630.1  cytosolic carboxypeptidase 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AK295774, AL157882, AL833359, CA449535, CN354118, CN354120, DA326833, DB078109
      Consensus CDS
      CCDS83382.1
      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
      Related
      ENSP00000349592.3, ENST00000357081.8
    4. NM_015239.3NP_056054.2  cytosolic carboxypeptidase 1 isoform b

      See identical proteins and their annotated locations for NP_056054.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an additional exon in the 5' region and thus differs in its 5' UTR and initiates translation from an alternate start codon, and it also uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      BC060815, CA449535
      Consensus CDS
      CCDS6672.1
      Related
      ENSP00000365251.3, ENST00000376083.7
      Conserved Domains (1) summary
      cd06906
      Location:8191096
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      85546539..85805483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423094.1XP_047279050.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    2. XM_047423090.1XP_047279046.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    3. XM_047423089.1XP_047279045.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    4. XM_047423088.1XP_047279044.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    5. XM_047423087.1XP_047279043.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    6. XM_047423086.1XP_047279042.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    7. XM_047423092.1XP_047279048.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    8. XM_047423093.1XP_047279049.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    9. XM_047423091.1XP_047279047.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    10. XM_005251848.3XP_005251905.1  cytosolic carboxypeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_005251905.1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
      Conserved Domains (1) summary
      cd06906
      Location:8591136
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    11. XM_047423097.1XP_047279053.1  cytosolic carboxypeptidase 1 isoform X2

    12. XM_047423095.1XP_047279051.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    13. XM_047423096.1XP_047279052.1  cytosolic carboxypeptidase 1 isoform X2

    14. XM_047423100.1XP_047279056.1  cytosolic carboxypeptidase 1 isoform X6

    15. XM_047423099.1XP_047279055.1  cytosolic carboxypeptidase 1 isoform X5

    16. XM_011518420.3XP_011516722.1  cytosolic carboxypeptidase 1 isoform X8

      Conserved Domains (1) summary
      cd06906
      Location:504781
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    17. XM_017014545.2XP_016870034.1  cytosolic carboxypeptidase 1 isoform X4

    18. XM_011518418.3XP_011516720.1  cytosolic carboxypeptidase 1 isoform X3

      Conserved Domains (1) summary
      cd06906
      Location:8591136
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    19. XM_047423098.1XP_047279054.1  cytosolic carboxypeptidase 1 isoform X3

    20. XM_047423101.1XP_047279057.1  cytosolic carboxypeptidase 1 isoform X7

    21. XM_011518421.3XP_011516723.1  cytosolic carboxypeptidase 1 isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      97697026..97955976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362522.1XP_054218497.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    2. XM_054362520.1XP_054218495.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    3. XM_054362521.1XP_054218496.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    4. XM_054362519.1XP_054218494.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    5. XM_054362518.1XP_054218493.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    6. XM_054362517.1XP_054218492.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    7. XM_054362516.1XP_054218491.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    8. XM_054362515.1XP_054218490.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    9. XM_054362514.1XP_054218489.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    10. XM_054362525.1XP_054218500.1  cytosolic carboxypeptidase 1 isoform X2

    11. XM_054362523.1XP_054218498.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    12. XM_054362524.1XP_054218499.1  cytosolic carboxypeptidase 1 isoform X2

    13. XM_054362530.1XP_054218505.1  cytosolic carboxypeptidase 1 isoform X6

    14. XM_054362529.1XP_054218504.1  cytosolic carboxypeptidase 1 isoform X5

    15. XM_054362532.1XP_054218507.1  cytosolic carboxypeptidase 1 isoform X8

    16. XM_054362528.1XP_054218503.1  cytosolic carboxypeptidase 1 isoform X4

    17. XM_054362526.1XP_054218501.1  cytosolic carboxypeptidase 1 isoform X3

    18. XM_054362527.1XP_054218502.1  cytosolic carboxypeptidase 1 isoform X3

    19. XM_054362531.1XP_054218506.1  cytosolic carboxypeptidase 1 isoform X7

    20. XM_054362533.1XP_054218508.1  cytosolic carboxypeptidase 1 isoform X9