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    Cnot3 CCR4-NOT transcription complex, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 232791, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cnot3provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 3provided by MGI
    Primary source
    MGI:MGI:2385261
    See related
    Ensembl:ENSMUSG00000035632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930039N10Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 10.9), limb E14.5 (RPKM 9.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cnot3 in Genome Data Viewer
    Location:
    7; 7 A1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (3645269..3661109)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (3596871..3612711)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene TCF3 (E2A) fusion partner Neighboring gene pre-mRNA processing factor 31 Neighboring gene predicted gene 15927 Neighboring gene microRNA 3572 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like gene family 4 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene tRNA splicing endonuclease subunit 34

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC40675

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of stem cell population maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    trophectodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 3
    Names
    CCR4-associated factor 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146176.3NP_666288.1  CCR4-NOT transcription complex subunit 3

      See identical proteins and their annotated locations for NP_666288.1

      Status: VALIDATED

      Source sequence(s)
      BC053437, BQ748712, CV783268
      Consensus CDS
      CCDS20721.1
      UniProtKB/Swiss-Prot
      Q8K0V4
      Related
      ENSMUSP00000039098.9, ENSMUST00000038913.15
      Conserved Domains (4) summary
      COG5665
      Location:12749
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam01328
      Location:303384
      Peroxidase_2; Peroxidase, family 2
      pfam04065
      Location:3229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:622743
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      3645269..3661109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539757.3XP_006539820.1  CCR4-NOT transcription complex subunit 3 isoform X3

      Conserved Domains (2) summary
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      cl02384
      Location:623683
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    2. XM_011250500.2XP_011248802.1  CCR4-NOT transcription complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_011248802.1

      Conserved Domains (4) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam01328
      Location:304385
      Peroxidase_2; Peroxidase, family 2
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:623744
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    3. XM_011250501.2XP_011248803.1  CCR4-NOT transcription complex subunit 3 isoform X2

      See identical proteins and their annotated locations for XP_011248803.1

      UniProtKB/Swiss-Prot
      Q8K0V4
      Conserved Domains (4) summary
      COG5665
      Location:12749
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam01328
      Location:303384
      Peroxidase_2; Peroxidase, family 2
      pfam04065
      Location:3229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:622743
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    4. XM_006539752.3XP_006539815.1  CCR4-NOT transcription complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006539815.1

      Conserved Domains (4) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam01328
      Location:304385
      Peroxidase_2; Peroxidase, family 2
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:623744
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    5. XM_006539755.3XP_006539818.1  CCR4-NOT transcription complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006539818.1

      Conserved Domains (4) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam01328
      Location:304385
      Peroxidase_2; Peroxidase, family 2
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:623744
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    6. XM_017322146.1XP_017177635.1  CCR4-NOT transcription complex subunit 3 isoform X2

      UniProtKB/Swiss-Prot
      Q8K0V4
      Conserved Domains (4) summary
      COG5665
      Location:12749
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam01328
      Location:303384
      Peroxidase_2; Peroxidase, family 2
      pfam04065
      Location:3229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:622743
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    7. XM_006539756.3XP_006539819.1  CCR4-NOT transcription complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006539819.1

      Conserved Domains (4) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam01328
      Location:304385
      Peroxidase_2; Peroxidase, family 2
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:623744
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    8. XM_006539753.3XP_006539816.1  CCR4-NOT transcription complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006539816.1

      Conserved Domains (4) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam01328
      Location:304385
      Peroxidase_2; Peroxidase, family 2
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:623744
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    9. XM_017322145.1XP_017177634.1  CCR4-NOT transcription complex subunit 3 isoform X1

      Conserved Domains (4) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam01328
      Location:304385
      Peroxidase_2; Peroxidase, family 2
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:623744
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    RNA

    1. XR_001785521.1 RNA Sequence

      Related
      ENSMUST00000143085.7
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