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    Cnot3 CCR4-NOT transcription complex, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 232791, updated on 24-Apr-2022

    Summary

    Official Symbol
    Cnot3provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 3provided by MGI
    Primary source
    MGI:MGI:2385261
    See related
    Ensembl:ENSMUSG00000035632 AllianceGenome:MGI:2385261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930039N10Rik
    Summary
    Involved in positive regulation of cold-induced thermogenesis; regulation of stem cell population maintenance; and trophectodermal cell differentiation. Located in P-body. Is expressed in several structures, including alimentary system; brain; gonad; hemolymphoid system gland; and white fat. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 10.9), limb E14.5 (RPKM 9.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cnot3 in Genome Data Viewer
    Location:
    7; 7 A1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3646717..3664108)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3645247..3661109)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (3596871..3612711)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TCF3 (E2A) fusion partner Neighboring gene pre-mRNA processing factor 31 Neighboring gene predicted gene 15927 Neighboring gene microRNA 3572 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like gene family 4 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene tRNA splicing endonuclease subunit 34

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC40675

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 3
    Names
    CCR4-associated factor 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146176.3NP_666288.1  CCR4-NOT transcription complex subunit 3

      See identical proteins and their annotated locations for NP_666288.1

      Status: VALIDATED

      Source sequence(s)
      BC053437, BQ748712, CV783268
      Consensus CDS
      CCDS20721.1
      UniProtKB/Swiss-Prot
      Q8K0V4
      Related
      ENSMUSP00000039098.10, ENSMUST00000038913.16
      Conserved Domains (2) summary
      COG5665
      Location:12749
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3229
      Not3; Not1 N-terminal domain, CCR4-Not complex component

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      3646717..3664108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152919.1XP_036008812.1  CCR4-NOT transcription complex subunit 3 isoform X1

      Conserved Domains (2) summary
      COG5665
      Location:210929
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:211409
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    2. XM_036152920.1XP_036008813.1  CCR4-NOT transcription complex subunit 3 isoform X2

      Conserved Domains (2) summary
      COG5665
      Location:210928
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:211408
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    3. XM_036152921.1XP_036008814.1  CCR4-NOT transcription complex subunit 3 isoform X3

      Conserved Domains (2) summary
      COG5665
      Location:209928
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:210408
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    4. XM_036152922.1XP_036008815.1  CCR4-NOT transcription complex subunit 3 isoform X4

      Conserved Domains (3) summary
      pfam05109
      Location:477744
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam04065
      Location:211409
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      cl02384
      Location:798860
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    5. XM_006539756.5XP_006539819.1  CCR4-NOT transcription complex subunit 3 isoform X7

      See identical proteins and their annotated locations for XP_006539819.1

      Conserved Domains (2) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    6. XM_030242409.2XP_030098269.1  CCR4-NOT transcription complex subunit 3 isoform X8

      Conserved Domains (2) summary
      COG5665
      Location:12749
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    7. XM_036152924.1XP_036008817.1  CCR4-NOT transcription complex subunit 3 isoform X6

      Conserved Domains (2) summary
      COG5665
      Location:130849
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:131329
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    8. XM_006539752.5XP_006539815.1  CCR4-NOT transcription complex subunit 3 isoform X7

      See identical proteins and their annotated locations for XP_006539815.1

      Conserved Domains (2) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    9. XM_036152927.1XP_036008820.1  CCR4-NOT transcription complex subunit 3 isoform X7

      Conserved Domains (2) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    10. XM_036152930.1XP_036008823.1  CCR4-NOT transcription complex subunit 3 isoform X8

      Conserved Domains (2) summary
      COG5665
      Location:12749
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    11. XM_006539753.5XP_006539816.1  CCR4-NOT transcription complex subunit 3 isoform X7

      See identical proteins and their annotated locations for XP_006539816.1

      Conserved Domains (2) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    12. XM_030242407.2XP_030098267.1  CCR4-NOT transcription complex subunit 3 isoform X8

      Conserved Domains (2) summary
      COG5665
      Location:12749
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    13. XM_017322146.3XP_017177635.1  CCR4-NOT transcription complex subunit 3 isoform X8

      UniProtKB/Swiss-Prot
      Q8K0V4
      Conserved Domains (2) summary
      COG5665
      Location:12749
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    14. XM_036152928.1XP_036008821.1  CCR4-NOT transcription complex subunit 3 isoform X7

      Conserved Domains (2) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    15. XM_006539755.5XP_006539818.1  CCR4-NOT transcription complex subunit 3 isoform X7

      See identical proteins and their annotated locations for XP_006539818.1

      Conserved Domains (2) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    16. XM_036152923.1XP_036008816.1  CCR4-NOT transcription complex subunit 3 isoform X5

      Conserved Domains (2) summary
      COG5665
      Location:131850
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:132330
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    17. XM_030242406.2XP_030098266.1  CCR4-NOT transcription complex subunit 3 isoform X8

      Conserved Domains (2) summary
      COG5665
      Location:12749
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    18. XM_036152926.1XP_036008819.1  CCR4-NOT transcription complex subunit 3 isoform X7

      Conserved Domains (2) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    19. XM_030242408.2XP_030098268.1  CCR4-NOT transcription complex subunit 3 isoform X8

      Conserved Domains (2) summary
      COG5665
      Location:12749
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3229
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    20. XM_036152931.1XP_036008824.1  CCR4-NOT transcription complex subunit 3 isoform X9

      Conserved Domains (1) summary
      COG5665
      Location:1663
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    21. XM_036152929.1XP_036008822.1  CCR4-NOT transcription complex subunit 3 isoform X7

      Conserved Domains (2) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
    22. XM_036152925.1XP_036008818.1  CCR4-NOT transcription complex subunit 3 isoform X7

      Conserved Domains (2) summary
      COG5665
      Location:12750
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3230
      Not3; Not1 N-terminal domain, CCR4-Not complex component

    RNA

    1. XR_004934061.1 RNA Sequence

    2. XR_003946437.2 RNA Sequence