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    Caprin2 caprin family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 232560, updated on 16-Oct-2021

    Summary

    Official Symbol
    Caprin2provided by MGI
    Official Full Name
    caprin family member 2provided by MGI
    Primary source
    MGI:MGI:2448541
    See related
    Ensembl:ENSMUSG00000030309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adir; Eeg1; C1qdc1; rng140
    Summary
    This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.2), limb E14.5 (RPKM 2.2) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Caprin2 in Genome Data Viewer
    Location:
    6; 6 G3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148743990..148797756, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148842492..148896257, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (148791034..148844648, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene importin 8 Neighboring gene RIKEN cDNA 2610017A05 gene Neighboring gene predicted gene, 36762 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene SIN3-HDAC complex associated factor Neighboring gene RIKEN cDNA 3010003L21 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA1873

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    caprin-2
    Names
    C1q domain containing 1
    C1q domain-containing protein 1
    RNA granule protein 140
    adiponectin r
    cytoplasmic activation/proliferation-associated protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301351.1NP_001288280.1  caprin-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AK129460, AK140744, BE946020
      UniProtKB/Swiss-Prot
      Q05A80
      Conserved Domains (3) summary
      COG2604
      Location:47177
      COG2604; Uncharacterized conserved protein [Function unknown]
      pfam00386
      Location:683808
      C1q; C1q domain
      pfam12287
      Location:317614
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    2. NM_181541.4NP_853519.2  caprin-2 isoform 1

      See identical proteins and their annotated locations for NP_853519.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK140744, BC125375, BE946020
      Consensus CDS
      CCDS39720.1
      UniProtKB/Swiss-Prot
      Q05A80
      UniProtKB/TrEMBL
      E4NKG5
      Related
      ENSMUSP00000107195.3, ENSMUST00000111569.9
      Conserved Domains (5) summary
      COG5022
      Location:110377
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:9031028
      C1q; C1q domain
      pfam12287
      Location:528839
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119234
      Caprin-1_dimer; Caprin-1 dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      148743990..148797756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507041.5XP_006507104.1  caprin-2 isoform X3

      Conserved Domains (5) summary
      COG5022
      Location:110367
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:8931018
      C1q; C1q domain
      pfam12287
      Location:518829
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119224
      Caprin-1_dimer; Caprin-1 dimerization domain
    2. XM_006507042.5XP_006507105.1  caprin-2 isoform X5

      UniProtKB/Swiss-Prot
      Q05A80
      Related
      ENSMUSP00000072165.6, ENSMUST00000072324.12
      Conserved Domains (4) summary
      pfam00386
      Location:684809
      C1q; C1q domain
      pfam12287
      Location:309620
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119234
      Caprin-1_dimer; Caprin-1 dimerization domain
    3. XM_036166093.1XP_036021986.1  caprin-2 isoform X6

      Conserved Domains (3) summary
      pfam00386
      Location:562687
      C1q; C1q domain
      pfam12287
      Location:187498
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:2112
      Caprin-1_dimer; Caprin-1 dimerization domain
    4. XM_006507039.5XP_006507102.1  caprin-2 isoform X1

      See identical proteins and their annotated locations for XP_006507102.1

      UniProtKB/Swiss-Prot
      Q05A80
      UniProtKB/TrEMBL
      E4NKG5
      Conserved Domains (5) summary
      COG5022
      Location:110377
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:9031028
      C1q; C1q domain
      pfam12287
      Location:528839
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119234
      Caprin-1_dimer; Caprin-1 dimerization domain
    5. XM_030255361.2XP_030111221.1  caprin-2 isoform X1

      Conserved Domains (5) summary
      COG5022
      Location:110377
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:9031028
      C1q; C1q domain
      pfam12287
      Location:528839
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119234
      Caprin-1_dimer; Caprin-1 dimerization domain
    6. XM_006507040.5XP_006507103.1  caprin-2 isoform X2

      Conserved Domains (5) summary
      COG5022
      Location:110377
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:9021027
      C1q; C1q domain
      pfam12287
      Location:528839
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119234
      Caprin-1_dimer; Caprin-1 dimerization domain
    7. XM_036166092.1XP_036021985.1  caprin-2 isoform X4

      Conserved Domains (4) summary
      COG5022
      Location:3255
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:781906
      C1q; C1q domain
      pfam12287
      Location:406717
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:2112
      Caprin-1_dimer; Caprin-1 dimerization domain
    8. XM_030255362.2XP_030111222.1  caprin-2 isoform X4

      Conserved Domains (4) summary
      COG5022
      Location:3255
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:781906
      C1q; C1q domain
      pfam12287
      Location:406717
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:2112
      Caprin-1_dimer; Caprin-1 dimerization domain

    RNA

    1. XR_004942949.1 RNA Sequence

    2. XR_004942948.1 RNA Sequence

    3. XR_004942950.1 RNA Sequence

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