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    Caprin2 caprin family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 232560, updated on 31-Jan-2019

    Summary

    Official Symbol
    Caprin2provided by MGI
    Official Full Name
    caprin family member 2provided by MGI
    Primary source
    MGI:MGI:2448541
    See related
    Ensembl:ENSMUSG00000030309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adir; Eeg1; C1qdc1; rng140
    Summary
    This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.2), limb E14.5 (RPKM 2.2) and 26 other tissues See more
    Orthologs

    Genomic context

    See Caprin2 in Genome Data Viewer
    Location:
    6; 6 G3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (148842492..148896258, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (148791034..148844648, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene importin 8 Neighboring gene RIKEN cDNA 2610017A05 gene Neighboring gene ribosomal protein S29 pseudogene Neighboring gene SIN3-HDAC complex associated factor Neighboring gene RIKEN cDNA 3010003L21 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA1873

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    caprin-2
    Names
    C1q domain containing 1
    C1q domain-containing protein 1
    RNA granule protein 140
    adiponectin r
    caprin2
    cytoplasmic activation/proliferation-associated protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301351.1NP_001288280.1  caprin-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AK129460, AK140744, BE946020
      UniProtKB/Swiss-Prot
      Q05A80
      Conserved Domains (3) summary
      COG2604
      Location:47177
      COG2604; Uncharacterized conserved protein [Function unknown]
      pfam00386
      Location:683808
      C1q; C1q domain
      pfam12287
      Location:317614
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    2. NM_181541.4NP_853519.2  caprin-2 isoform 1

      See identical proteins and their annotated locations for NP_853519.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK140744, BC125375, BE946020
      Consensus CDS
      CCDS39720.1
      UniProtKB/Swiss-Prot
      Q05A80
      UniProtKB/TrEMBL
      E4NKG5
      Related
      ENSMUSP00000107195.2, ENSMUST00000111569.8
      Conserved Domains (3) summary
      COG2604
      Location:47177
      COG2604; Uncharacterized conserved protein [Function unknown]
      pfam00386
      Location:9031028
      C1q; C1q domain
      pfam12287
      Location:536833
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      148842492..148896258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507041.3XP_006507104.1  caprin-2 isoform X3

      Conserved Domains (3) summary
      COG2604
      Location:47177
      COG2604; Uncharacterized conserved protein [Function unknown]
      pfam00386
      Location:8931018
      C1q; C1q domain
      pfam12287
      Location:526823
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    2. XM_006507040.3XP_006507103.1  caprin-2 isoform X2

      Conserved Domains (3) summary
      COG2604
      Location:47177
      COG2604; Uncharacterized conserved protein [Function unknown]
      pfam00386
      Location:9021027
      C1q; C1q domain
      pfam12287
      Location:536833
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    3. XM_006507039.3XP_006507102.1  caprin-2 isoform X1

      See identical proteins and their annotated locations for XP_006507102.1

      UniProtKB/Swiss-Prot
      Q05A80
      UniProtKB/TrEMBL
      E4NKG5
      Conserved Domains (3) summary
      COG2604
      Location:47177
      COG2604; Uncharacterized conserved protein [Function unknown]
      pfam00386
      Location:9031028
      C1q; C1q domain
      pfam12287
      Location:536833
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    4. XM_006507042.3XP_006507105.1  caprin-2 isoform X5

      UniProtKB/Swiss-Prot
      Q05A80
      Related
      ENSMUSP00000072165.5, ENSMUST00000072324.11
      Conserved Domains (3) summary
      COG2604
      Location:47177
      COG2604; Uncharacterized conserved protein [Function unknown]
      pfam00386
      Location:684809
      C1q; C1q domain
      pfam12287
      Location:317614
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    5. XM_017321562.1XP_017177051.1  caprin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q05A80
      UniProtKB/TrEMBL
      E4NKG5
      Conserved Domains (3) summary
      COG2604
      Location:47177
      COG2604; Uncharacterized conserved protein [Function unknown]
      pfam00386
      Location:9031028
      C1q; C1q domain
      pfam12287
      Location:536833
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    6. XM_017321563.1XP_017177052.1  caprin-2 isoform X4

    7. XM_017321564.1XP_017177053.1  caprin-2 isoform X4

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_166305.2 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      5310223..5340894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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