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    ANKRD28 ankyrin repeat domain 28 [ Homo sapiens (human) ]

    Gene ID: 23243, updated on 8-Jul-2021

    Summary

    Official Symbol
    ANKRD28provided by HGNC
    Official Full Name
    ankyrin repeat domain 28provided by HGNC
    Primary source
    HGNC:HGNC:29024
    See related
    Ensembl:ENSG00000206560 MIM:611122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PITK; FAP79; CFAP79; PPP1R65
    Expression
    Ubiquitous expression in bone marrow (RPKM 14.3), testis (RPKM 10.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ANKRD28 in Genome Data Viewer
    Location:
    3p25.1
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (15667236..15859814, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (15708743..15901321, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene RNA, 7SL, cytoplasmic 110, pseudogene Neighboring gene 2-hydroxyacyl-CoA lyase 1 Neighboring gene biotinidase Neighboring gene microRNA 3134 Neighboring gene uncharacterized LOC101927647 Neighboring gene RNA, 7SL, cytoplasmic 4, pseudogene Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 8 Neighboring gene microRNA 563

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0379

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
    Names
    PP6-ARS-A
    ankyrin repeat domain-containing protein 28
    phosphatase interactor targeting K protein
    phosphatase interactor targeting protein hnRNP K
    protein phosphatase 1, regulatory subunit 65
    protein phosphatase 6 ankyrin repeat subunit A
    serine/threonine-protein phosphatase 6 regulatory subunit ARS-A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195098.1NP_001182027.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform b

      See identical proteins and their annotated locations for NP_001182027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 3 and 10, encodes isoform b.
      Source sequence(s)
      AC090950, AK293770, AY367056, BQ423818
      Consensus CDS
      CCDS74908.1
      UniProtKB/Swiss-Prot
      O15084
      Related
      ENSP00000485421.1, ENST00000624145.3
      Conserved Domains (6) summary
      PHA02874
      Location:400709
      PHA02874; ankyrin repeat protein; Provisional
      PHA03095
      Location:65321
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:2249
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:773803
      Ank; Ankyrin repeat
      pfam12796
      Location:673766
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:1116
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_001195099.2NP_001182028.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform b

      See identical proteins and their annotated locations for NP_001182028.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 2 and 10, encodes isoform b.
      Source sequence(s)
      AC090950, AK293770, AY367056, BQ423818
      Consensus CDS
      CCDS74908.1
      UniProtKB/Swiss-Prot
      O15084
      Conserved Domains (6) summary
      PHA02874
      Location:400709
      PHA02874; ankyrin repeat protein; Provisional
      PHA03095
      Location:65321
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:2249
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:773803
      Ank; Ankyrin repeat
      pfam12796
      Location:673766
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:1116
      Ank_2; Ankyrin repeats (3 copies)
    3. NM_001349277.2NP_001336206.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes isoform c.
      Source sequence(s)
      AC090950
      Conserved Domains (5) summary
      PHA02874
      Location:587896
      PHA02874; ankyrin repeat protein; Provisional
      PHA03095
      Location:55343
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:173203
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:960990
      Ank; Ankyrin repeat
      pfam12796
      Location:860953
      Ank_2; Ankyrin repeats (3 copies)
    4. NM_001349278.2NP_001336207.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes isoform d.
      Source sequence(s)
      AC090950
      Related
      ENSP00000508086.1, ENST00000683139.1
      Conserved Domains (5) summary
      PHA02874
      Location:584893
      PHA02874; ankyrin repeat protein; Provisional
      PHA03095
      Location:52340
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:170200
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:957987
      Ank; Ankyrin repeat
      pfam12796
      Location:857950
      Ank_2; Ankyrin repeats (3 copies)
    5. NM_001349279.2NP_001336208.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) encodes isoform e.
      Source sequence(s)
      AC090945, AC090950
      Conserved Domains (5) summary
      PHA02874
      Location:551860
      PHA02874; ankyrin repeat protein; Provisional
      PHA03095
      Location:19307
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:137167
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:924954
      Ank; Ankyrin repeat
      pfam12796
      Location:824917
      Ank_2; Ankyrin repeats (3 copies)
    6. NM_001349280.1NP_001336209.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 8 and 9, encodes isoform f.
      Source sequence(s)
      AC090950
      Conserved Domains (5) summary
      cd00204
      Location:78203
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:84114
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:319360
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:483534
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:30303
      Ank_2; Ankyrin repeats (3 copies)
    7. NM_001349281.2NP_001336210.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 7 and 9, encodes isoform f.
      Source sequence(s)
      AC090950
      Conserved Domains (5) summary
      cd00204
      Location:78203
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:84114
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:319360
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:483534
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:30303
      Ank_2; Ankyrin repeats (3 copies)
    8. NM_001349282.2NP_001336211.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 7 and 8, encodes isoform f.
      Source sequence(s)
      AC090950
      Conserved Domains (5) summary
      cd00204
      Location:78203
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:84114
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:319360
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:483534
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:30303
      Ank_2; Ankyrin repeats (3 copies)
    9. NM_001349283.2NP_001336212.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 2 and 3, encodes isoform b.
      Source sequence(s)
      AC090950
      Consensus CDS
      CCDS74908.1
      Conserved Domains (6) summary
      PHA02874
      Location:400709
      PHA02874; ankyrin repeat protein; Provisional
      PHA03095
      Location:65321
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:2249
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:773803
      Ank; Ankyrin repeat
      pfam12796
      Location:673766
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:1116
      Ank_2; Ankyrin repeats (3 copies)
    10. NM_001349284.2NP_001336213.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) encodes isoform g.
      Source sequence(s)
      AC090950
    11. NM_001349285.2NP_001336214.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) encodes isoform h.
      Source sequence(s)
      AC090950
      Related
      ENST00000461696.1
    12. NM_015199.4NP_056014.2  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform a

      See identical proteins and their annotated locations for NP_056014.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC090945, AC090950, AI565587, AK293770, AY367056, BQ423818, CN313636
      Consensus CDS
      CCDS46769.1
      UniProtKB/Swiss-Prot
      O15084
      UniProtKB/TrEMBL
      A0A024R2G8
      Related
      ENSP00000382379.2, ENST00000399451.6
      Conserved Domains (5) summary
      PHA02874
      Location:554863
      PHA02874; ankyrin repeat protein; Provisional
      PHA03095
      Location:22310
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:140170
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:927957
      Ank; Ankyrin repeat
      pfam12796
      Location:827920
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. NR_146111.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090950
    2. NR_146112.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090950

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      15667236..15859814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453418.1XP_024309186.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1

      Conserved Domains (6) summary
      cd00204
      Location:661790
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:154184
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:456540
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:942993
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:553604
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:36324
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_011533542.3XP_011531844.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X5

      See identical proteins and their annotated locations for XP_011531844.1

      Conserved Domains (6) summary
      cd00204
      Location:619748
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:112142
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:414498
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:900951
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:511562
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:6273
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_024453419.1XP_024309187.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X2

      Conserved Domains (6) summary
      cd00204
      Location:658787
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:151181
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:453537
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:939990
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:550601
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:33321
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_024453420.1XP_024309188.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X4

      Conserved Domains (5) summary
      cd00204
      Location:594723
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:123150
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:322363
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:486537
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:36306
      Ank_2; Ankyrin repeats (3 copies)
    5. XM_024453422.1XP_024309190.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X6

      Conserved Domains (5) summary
      cd00204
      Location:78203
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:84114
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:319360
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:483534
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:30303
      Ank_2; Ankyrin repeats (3 copies)
    6. XM_024453424.1XP_024309192.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X6

      Conserved Domains (5) summary
      cd00204
      Location:78203
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:84114
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:319360
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:483534
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:30303
      Ank_2; Ankyrin repeats (3 copies)
    7. XM_011533547.3XP_011531849.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X6

      See identical proteins and their annotated locations for XP_011531849.1

      Conserved Domains (5) summary
      cd00204
      Location:78203
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:84114
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:319360
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:483534
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:30303
      Ank_2; Ankyrin repeats (3 copies)
    8. XM_024453421.1XP_024309189.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X6

      Conserved Domains (5) summary
      cd00204
      Location:78203
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:84114
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:319360
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:483534
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:30303
      Ank_2; Ankyrin repeats (3 copies)
    9. XM_024453423.1XP_024309191.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X6

      Conserved Domains (5) summary
      cd00204
      Location:78203
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:84114
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:319360
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:483534
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:30303
      Ank_2; Ankyrin repeats (3 copies)
    10. XM_017006029.1XP_016861518.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X7

    11. XM_011533541.3XP_011531843.2  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X3

      Conserved Domains (5) summary
      cd00204
      Location:661790
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:154184
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:456540
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:553604
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:36324
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_002959503.1 RNA Sequence

    2. XR_001740071.2 RNA Sequence

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