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    Wnk1 WNK lysine deficient protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 232341, updated on 5-Sep-2021

    Summary

    Official Symbol
    Wnk1provided by MGI
    Official Full Name
    WNK lysine deficient protein kinase 1provided by MGI
    Primary source
    MGI:MGI:2442092
    See related
    Ensembl:ENSMUSG00000045962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hs; Hsn2; Prkw; Prkwnk1; EG406236; mKIAA0344; 6430573H23Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 40.9), thymus adult (RPKM 32.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Wnk1 in Genome Data Viewer
    Location:
    6; 6 F1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119900930..120015659, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119923969..120038695, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (119873987..119988673, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 76, member A pseudogene Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene microRNA 706 Neighboring gene ninjurin 2 Neighboring gene predicted gene, 25327 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC175896, MGC175898

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chloride channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chloride channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables potassium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to chemokine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to chemokine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemokine (C-C motif) ligand 21 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lymphocyte migration into lymph node IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of pancreatic juice secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of regulation of cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase WNK1
    Names
    protein kinase lysine-deficient 1
    protein kinase with no lysine 1
    NP_001171949.1
    NP_001171950.1
    NP_001186012.1
    NP_001186013.1
    NP_941992.2
    XP_011239622.1
    XP_017177031.1
    XP_017177038.1
    XP_017177039.1
    XP_017177041.1
    XP_017177043.1
    XP_017177044.1
    XP_017177045.1
    XP_017177046.1
    XP_030111215.1
    XP_036021959.1
    XP_036021960.1
    XP_036021961.1
    XP_036021962.1
    XP_036021963.1
    XP_036021964.1
    XP_036021965.1
    XP_036021966.1
    XP_036021967.1
    XP_036021968.1
    XP_036021969.1
    XP_036021970.1
    XP_036021971.1
    XP_036021972.1
    XP_036021973.1
    XP_036021974.1
    XP_036021975.1
    XP_036021976.1
    XP_036021977.1
    XP_036021978.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185020.1NP_001171949.1  serine/threonine-protein kinase WNK1 isoform 2

      See identical proteins and their annotated locations for NP_001171949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 5.
      Source sequence(s)
      AK133738, BC056761, BC138445
      Consensus CDS
      CCDS85147.1
      UniProtKB/Swiss-Prot
      P83741
      Related
      ENSMUSP00000145304.2, ENSMUST00000203030.3
      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam09770
      Location:677812
      PAT1; Topoisomerase II-associated protein PAT1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    2. NM_001185021.1NP_001171950.1  serine/threonine-protein kinase WNK1 isoform 3

      See identical proteins and their annotated locations for NP_001171950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 5.
      Source sequence(s)
      AK133738, BC056761, BC145282
      Consensus CDS
      CCDS51888.1
      UniProtKB/Swiss-Prot
      P83741
      Related
      ENSMUSP00000086019.6, ENSMUST00000088646.12
      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    3. NM_001199083.1NP_001186012.1  serine/threonine-protein kinase WNK1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 5. This variant represents the exon combination of the brain and spinal cord variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 4, which is shorter than isoform 5 but has the same N- and C-termini.
      Source sequence(s)
      AC113092, AK133738, BC054836, BC171955, CN693598
      Consensus CDS
      CCDS57445.1
      UniProtKB/Swiss-Prot
      P83741
      UniProtKB/TrEMBL
      Q7TPR2
      Related
      ENSMUSP00000136777.2, ENSMUST00000177761.8
      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    4. NM_001199084.1NP_001186013.1  serine/threonine-protein kinase WNK1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5). This variant represents the exon combination of the dorsal root ganglia and sciatic nerve variant described in Figure 2F of PubMed ID 18521183.
      Source sequence(s)
      AC113092, AK133738, BC054836, BC145282, BC171955, CN693598
      Consensus CDS
      CCDS57444.1
      UniProtKB/Swiss-Prot
      P83741
      UniProtKB/TrEMBL
      Q7TPR2
      Related
      ENSMUSP00000086017.7, ENSMUST00000088644.13
      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    5. NM_198703.3NP_941992.2  serine/threonine-protein kinase WNK1 isoform 1

      See identical proteins and their annotated locations for NP_941992.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 5.
      Source sequence(s)
      AK133738, AY309076, BC056761, BC171955
      Consensus CDS
      CCDS20478.1
      UniProtKB/Swiss-Prot
      P83741
      Related
      ENSMUSP00000063001.7, ENSMUST00000060043.13
      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      119900930..120015659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166066.1XP_036021959.1  serine/threonine-protein kinase WNK1 isoform X1

      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam03154
      Location:11521564
      Atrophin-1; Atrophin-1 family
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    2. XM_036166085.1XP_036021978.1  serine/threonine-protein kinase WNK1 isoform X30

      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam03154
      Location:10661478
      Atrophin-1; Atrophin-1 family
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    3. XM_017321556.1XP_017177045.1  serine/threonine-protein kinase WNK1 isoform X28

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    4. XM_030255355.1XP_030111215.1  serine/threonine-protein kinase WNK1 isoform X25

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    5. XM_036166084.1XP_036021977.1  serine/threonine-protein kinase WNK1 isoform X23

      Conserved Domains (3) summary
      PRK14949
      Location:587957
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    6. XM_011241320.2XP_011239622.1  serine/threonine-protein kinase WNK1 isoform X20

      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam03154
      Location:6461092
      Atrophin-1; Atrophin-1 family
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    7. XM_017321557.1XP_017177046.1  serine/threonine-protein kinase WNK1 isoform X29

      UniProtKB/Swiss-Prot
      P83741
      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam09770
      Location:677812
      PAT1; Topoisomerase II-associated protein PAT1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    8. XM_017321555.1XP_017177044.1  serine/threonine-protein kinase WNK1 isoform X27

      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam09770
      Location:677812
      PAT1; Topoisomerase II-associated protein PAT1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    9. XM_017321554.1XP_017177043.1  serine/threonine-protein kinase WNK1 isoform X26

      UniProtKB/Swiss-Prot
      P83741
      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    10. XM_017321552.1XP_017177041.1  serine/threonine-protein kinase WNK1 isoform X24

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    11. XM_017321550.1XP_017177039.1  serine/threonine-protein kinase WNK1 isoform X22

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    12. XM_017321549.1XP_017177038.1  serine/threonine-protein kinase WNK1 isoform X21

      UniProtKB/Swiss-Prot
      P83741
      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    13. XM_017321542.3XP_017177031.1  serine/threonine-protein kinase WNK1 isoform X19

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    14. XM_036166082.1XP_036021975.1  serine/threonine-protein kinase WNK1 isoform X17

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    15. XM_036166079.1XP_036021972.1  serine/threonine-protein kinase WNK1 isoform X14

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    16. XM_036166076.1XP_036021969.1  serine/threonine-protein kinase WNK1 isoform X11

      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam03154
      Location:10661478
      Atrophin-1; Atrophin-1 family
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    17. XM_036166081.1XP_036021974.1  serine/threonine-protein kinase WNK1 isoform X16

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    18. XM_036166067.1XP_036021960.1  serine/threonine-protein kinase WNK1 isoform X2

      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam03154
      Location:11521563
      Atrophin-1; Atrophin-1 family
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    19. XM_036166083.1XP_036021976.1  serine/threonine-protein kinase WNK1 isoform X18

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    20. XM_036166080.1XP_036021973.1  serine/threonine-protein kinase WNK1 isoform X15

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    21. XM_036166078.1XP_036021971.1  serine/threonine-protein kinase WNK1 isoform X13

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    22. XM_036166077.1XP_036021970.1  serine/threonine-protein kinase WNK1 isoform X12

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    23. XM_036166075.1XP_036021968.1  serine/threonine-protein kinase WNK1 isoform X10

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    24. XM_036166071.1XP_036021964.1  serine/threonine-protein kinase WNK1 isoform X6

      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam03154
      Location:11521564
      Atrophin-1; Atrophin-1 family
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    25. XM_036166074.1XP_036021967.1  serine/threonine-protein kinase WNK1 isoform X9

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    26. XM_036166073.1XP_036021966.1  serine/threonine-protein kinase WNK1 isoform X8

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    27. XM_036166072.1XP_036021965.1  serine/threonine-protein kinase WNK1 isoform X7

      Conserved Domains (2) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    28. XM_036166070.1XP_036021963.1  serine/threonine-protein kinase WNK1 isoform X5

      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam03154
      Location:11521564
      Atrophin-1; Atrophin-1 family
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    29. XM_036166068.1XP_036021961.1  serine/threonine-protein kinase WNK1 isoform X3

      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam03154
      Location:11521564
      Atrophin-1; Atrophin-1 family
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    30. XM_036166069.1XP_036021962.1  serine/threonine-protein kinase WNK1 isoform X4

      Conserved Domains (3) summary
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam03154
      Location:11521564
      Atrophin-1; Atrophin-1 family
      pfam12202
      Location:500563
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037155.1: Suppressed sequence

      Description
      NM_001037155.1: This RefSeq was permanently suppressed because it represents a nervous system-specific exon of WNK1, GeneID 232341, but there currently is insufficient support for a transcript containing this exon.
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