U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    RHOBTB2 Rho related BTB domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 23221, updated on 3-Apr-2024

    Summary

    Official Symbol
    RHOBTB2provided by HGNC
    Official Full Name
    Rho related BTB domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:18756
    See related
    Ensembl:ENSG00000008853 MIM:607352; AllianceGenome:HGNC:18756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p83; DBC2; DEE64; EIEE64
    Summary
    The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Broad expression in lung (RPKM 11.1), brain (RPKM 8.7) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    8p21.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22950813..23020199)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (23225786..23295160)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22844764..22877712)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene uncharacterized LOC101929237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27097 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22744265-22744765 Neighboring gene uncharacterized LOC124901907 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22760306-22760493 Neighboring gene Sharpr-MPRA regulatory region 3596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22769137-22769908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22769909-22770680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22777059-22777987 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22809645-22810276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22810277-22810907 Neighboring gene uncharacterized LOC107984124 Neighboring gene NANOG hESC enhancer GRCh37_chr8:22814761-22815262 Neighboring gene VISTA enhancer hs1927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22845205-22845961 Neighboring gene RNA, 7SL, cytoplasmic 303, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22861268-22861793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22861794-22862318 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:22866186-22866771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22871840-22872604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27102 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22876025-22876192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22876488-22877052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22877053-22877615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22885758-22886258 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22886259-22886759 Neighboring gene TNF receptor superfamily member 10b Neighboring gene Sharpr-MPRA regulatory region 6582 Neighboring gene TNFRSF10B antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:22921484-22922683 Neighboring gene TNFRSF10B 5' regulatory region Neighboring gene Sharpr-MPRA regulatory region 12406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22928365-22928864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22941919-22942800 Neighboring gene uncharacterized LOC254896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22960499-22961308 Neighboring gene TNF receptor superfamily member 10c

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0717

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    rho-related BTB domain-containing protein 2
    Names
    deleted in breast cancer 2 gene protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047133.2 RefSeqGene

      Range
      53737..74388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001160036.2NP_001153508.1  rho-related BTB domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001153508.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA641575, AB018260, AC107959, AK292863, AY009093, BC034917, BG255120
      Consensus CDS
      CCDS55210.1
      UniProtKB/TrEMBL
      A0A8I5KV41
      Related
      ENSP00000427926.1, ENST00000519685.5
      Conserved Domains (5) summary
      cd01873
      Location:35229
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00174
      Location:39230
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      smart00225
      Location:523615
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:513615
      BTB; BTB/POZ domain
      cl02518
      Location:443490
      BTB; BTB/POZ domain
    2. NM_001160037.2NP_001153509.1  rho-related BTB domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC107959
      Consensus CDS
      CCDS55211.1
      UniProtKB/TrEMBL
      A0A8I5KV41
      Related
      ENSP00000429141.1, ENST00000522948.5
      Conserved Domains (5) summary
      cd01873
      Location:20214
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00174
      Location:24215
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      smart00225
      Location:508600
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:498600
      BTB; BTB/POZ domain
      cl02518
      Location:428475
      BTB; BTB/POZ domain
    3. NM_001374791.1NP_001361720.1  rho-related BTB domain-containing protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC107959
      Consensus CDS
      CCDS6034.1
      UniProtKB/Swiss-Prot
      A8K9Z8, D3DSR8, E9PBU2, E9PEI7, O94825, Q8N4A8, Q9BYZ6, Q9BZK6
      UniProtKB/TrEMBL
      A0A8I5KV41
      Related
      ENSP00000509630.1, ENST00000692529.1
      Conserved Domains (4) summary
      cd01873
      Location:13207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18356
      Location:250475
      BTB1_POZ_RHOBTB2; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cd18359
      Location:480603
      BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cd18531
      Location:608704
      BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    4. NM_015178.3NP_055993.2  rho-related BTB domain-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_055993.2

      Status: REVIEWED

      Source sequence(s)
      AC107959
      Consensus CDS
      CCDS6034.1
      UniProtKB/Swiss-Prot
      A8K9Z8, D3DSR8, E9PBU2, E9PEI7, O94825, Q8N4A8, Q9BYZ6, Q9BZK6
      UniProtKB/TrEMBL
      A0A8I5KV41
      Related
      ENSP00000251822.7, ENST00000251822.7
      Conserved Domains (4) summary
      cd01873
      Location:13207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18356
      Location:250475
      BTB1_POZ_RHOBTB2; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cd18359
      Location:480603
      BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cd18531
      Location:608704
      BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      22950813..23020199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421609.1XP_047277565.1  rho-related BTB domain-containing protein 2 isoform X1

    2. XM_047421611.1XP_047277567.1  rho-related BTB domain-containing protein 2 isoform X1

    3. XM_047421610.1XP_047277566.1  rho-related BTB domain-containing protein 2 isoform X1

    4. XM_047421607.1XP_047277563.1  rho-related BTB domain-containing protein 2 isoform X1

    5. XM_047421608.1XP_047277564.1  rho-related BTB domain-containing protein 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      23225786..23295160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360181.1XP_054216156.1  rho-related BTB domain-containing protein 2 isoform X1

    2. XM_054360183.1XP_054216158.1  rho-related BTB domain-containing protein 2 isoform X1

    3. XM_054360182.1XP_054216157.1  rho-related BTB domain-containing protein 2 isoform X1

    4. XM_054360179.1XP_054216154.1  rho-related BTB domain-containing protein 2 isoform X1

    5. XM_054360180.1XP_054216155.1  rho-related BTB domain-containing protein 2 isoform X1