Format

Send to:

Choose Destination
    • Showing Current items.

    Arhgap25 Rho GTPase activating protein 25 [ Mus musculus (house mouse) ]

    Gene ID: 232201, updated on 7-Aug-2021

    Summary

    Official Symbol
    Arhgap25provided by MGI
    Official Full Name
    Rho GTPase activating protein 25provided by MGI
    Primary source
    MGI:MGI:2443687
    See related
    Ensembl:ENSMUSG00000030047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A130039I20Rik
    Expression
    Broad expression in spleen adult (RPKM 4.7), thymus adult (RPKM 2.9) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arhgap25 in Genome Data Viewer
    Location:
    6; 6 D1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87435526..87510241, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87458544..87533261, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (87409379..87483229, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene gastrokine 3 Neighboring gene bone morphogenetic protein 10 Neighboring gene prokineticin receptor 1 Neighboring gene predicted gene, 34222 Neighboring gene predicted gene, 34312

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Chemically induced (ENU) (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in phagocytic cup IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 25
    Names
    rho-type GTPase-activating protein 25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037727.2NP_001032816.1  rho GTPase-activating protein 25 isoform a

      See identical proteins and their annotated locations for NP_001032816.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK037710, AK137526, AK159941
      Consensus CDS
      CCDS20321.1
      UniProtKB/Swiss-Prot
      Q8BYW1
      Related
      ENSMUSP00000109267.3, ENSMUST00000113637.9
      Conserved Domains (3) summary
      cd04390
      Location:156354
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13263
      Location:45157
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:47149
      PH; PH domain
    2. NM_001286610.1NP_001273539.1  rho GTPase-activating protein 25 isoform c

      See identical proteins and their annotated locations for NP_001273539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK137526, AK159941
      Consensus CDS
      CCDS71790.1
      UniProtKB/Swiss-Prot
      Q8BYW1
      Related
      ENSMUSP00000068964.7, ENSMUST00000071024.7
      Conserved Domains (3) summary
      cd04390
      Location:67265
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:360
      PH; PH domain
      cl17171
      Location:168
      PH-like; Pleckstrin homology-like domain
    3. NM_175476.4NP_780685.2  rho GTPase-activating protein 25 isoform b

      See identical proteins and their annotated locations for NP_780685.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform b, which has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK137444, AK137526, CJ145934
      Consensus CDS
      CCDS20322.1
      UniProtKB/Swiss-Prot
      Q8BYW1
      Related
      ENSMUSP00000098758.3, ENSMUST00000101197.9
      Conserved Domains (3) summary
      cd04390
      Location:130328
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13263
      Location:19131
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:21123
      PH; PH domain

    RNA

    1. NR_104483.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate terminal 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK137526, CJ145934
      Related
      ENSMUST00000145128.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      87435526..87510241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166049.1XP_036021942.1  rho GTPase-activating protein 25 isoform X2

      Conserved Domains (2) summary
      cd04390
      Location:130328
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      cd13263
      Location:19131
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    2. XM_017321531.2XP_017177020.1  rho GTPase-activating protein 25 isoform X1

      Conserved Domains (4) summary
      COG1196
      Location:505606
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd04390
      Location:117315
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam05667
      Location:381602
      DUF812; Protein of unknown function (DUF812)
      cl17171
      Location:45122
      PH-like; Pleckstrin homology-like domain
    3. XM_006505980.4XP_006506043.1  rho GTPase-activating protein 25 isoform X3

      Conserved Domains (3) summary
      COG1196
      Location:426527
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd04390
      Location:38236
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam05667
      Location:302523
      DUF812; Protein of unknown function (DUF812)
    Support Center