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    DTX4 deltex E3 ubiquitin ligase 4 [ Homo sapiens (human) ]

    Gene ID: 23220, updated on 28-Oct-2024

    Summary

    Official Symbol
    DTX4provided by HGNC
    Official Full Name
    deltex E3 ubiquitin ligase 4provided by HGNC
    Primary source
    HGNC:HGNC:29151
    See related
    Ensembl:ENSG00000110042 MIM:616110; AllianceGenome:HGNC:29151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF155
    Summary
    Enables ubiquitin protein ligase activity. Involved in negative regulation of innate immune response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Is active in centrosome. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 13.0), lung (RPKM 11.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DTX4 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (59171430..59208588)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (59120605..59157761)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58938903..58976061)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FAM111A divergent transcript Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4747 Neighboring gene FAM111 trypsin like peptidase A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4749 Neighboring gene basic proline-rich protein-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58938742-58939282 Neighboring gene Sharpr-MPRA regulatory region 11967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58940291-58941119 Neighboring gene uncharacterized LOC124902675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3363 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:58967822-58969021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4753 Neighboring gene macrophage expressed 1 Neighboring gene RNA, 7SL, cytoplasmic 42, pseudogene Neighboring gene tryptophanyl-tRNA synthetase 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of deltex homolog 4 (DTX4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0937, MGC141899

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase DTX4
    Names
    RING finger protein 155
    RING-type E3 ubiquitin transferase DTX4
    deltex 4 homolog
    deltex 4, E3 ubiquitin ligase
    deltex homolog 4
    deltex4
    protein deltex-4
    NP_001287656.1
    NP_055992.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300727.2NP_001287656.1  E3 ubiquitin-protein ligase DTX4 isoform 2

      See identical proteins and their annotated locations for NP_001287656.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AP002358, BC119011
      Consensus CDS
      CCDS76408.1
      UniProtKB/Swiss-Prot
      Q9Y2E6
      Related
      ENSP00000434055.1, ENST00000532982.5
      Conserved Domains (4) summary
      cd09633
      Location:370502
      Deltex_C; Domain found at the C-terminus of deltex-like
      pfam02825
      Location:138
      WWE; WWE domain
      cd16671
      Location:300366
      RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
      cl26464
      Location:63259
      Atrophin-1; Atrophin-1 family
    2. NM_015177.2NP_055992.1  E3 ubiquitin-protein ligase DTX4 isoform 1

      See identical proteins and their annotated locations for NP_055992.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB023154, AP001258, AP002358, BF195769
      Consensus CDS
      CCDS44612.1
      UniProtKB/Swiss-Prot
      Q0VF38, Q9Y2E6
      Related
      ENSP00000227451.3, ENST00000227451.4
      Conserved Domains (4) summary
      smart00678
      Location:886
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:476608
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:408469
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam02825
      Location:90144
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      59171430..59208588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      59120605..59157761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)