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    PSME4 proteasome activator subunit 4 [ Homo sapiens (human) ]

    Gene ID: 23198, updated on 5-Mar-2024

    Summary

    Official Symbol
    PSME4provided by HGNC
    Official Full Name
    proteasome activator subunit 4provided by HGNC
    Primary source
    HGNC:HGNC:20635
    See related
    Ensembl:ENSG00000068878 MIM:607705; AllianceGenome:HGNC:20635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PA200
    Summary
    Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and spermatogenesis, exchange of chromosomal proteins. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 32.8), endometrium (RPKM 14.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PSME4 in Genome Data Viewer
    Location:
    2p16.2
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (53864069..53970993, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (53860299..53967209, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (54091206..54198130, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene GPR75-ASB3 readthrough Neighboring gene microRNA 3682 Neighboring gene G protein-coupled receptor 75 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:54196978-54197742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11482 Neighboring gene Sharpr-MPRA regulatory region 11857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11484 Neighboring gene acylphosphatase 2 Neighboring gene uncharacterized LOC124906138 Neighboring gene ribosomal protein L21 pseudogene 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
    tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
    tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
    tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
    Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
    integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21864, KIAA0077, MGC138374, MGC142228

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lysine-acetylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasomal ubiquitin-independent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasomal ubiquitin-independent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sperm DNA condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of spermatoproteasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of spermatoproteasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    proteasome activator complex subunit 4
    Names
    proteasome (prosome, macropain) activator subunit 4
    proteasome activator 200 kDa
    proteasome activator PA200

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014614.3NP_055429.2  proteasome activator complex subunit 4

      See identical proteins and their annotated locations for NP_055429.2

      Status: VALIDATED

      Source sequence(s)
      AA884260, AC008068, AL045471, AY894754, BC113668
      Consensus CDS
      CCDS33197.2
      UniProtKB/Swiss-Prot
      Q14997, Q1XBG4, Q1XBG5, Q1XBG6, Q2M1Z0, Q6IPR2, Q86XF8
      Related
      ENSP00000384211.1, ENST00000404125.6
      Conserved Domains (3) summary
      sd00044
      Location:16421671
      HEAT; HEAT repeat [structural motif]
      pfam11919
      Location:17571842
      DUF3437; Domain of unknown function (DUF3437)
      pfam16507
      Location:330828
      BLM10_mid; Proteasome-substrate-size regulator, mid region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      53864069..53970993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      53860299..53967209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)