Mepce methylphosphate capping enzyme [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mepceprovided by MGI
Official Full Name: methylphosphate capping enzymeprovided by MGI
Primary source: MGI:MGI:106477
See related: Ensembl:ENSMUSG00000029726 AllianceGenome:MGI:106477
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bcdin3; D5Wsu46e
Summary: Predicted to enable 7SK snRNA binding activity and RNA 5'-methyltransferase activity. Acts upstream of or within negative regulation of chromatin binding activity; negative regulation of transcription by RNA polymerase II; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in nucleus. Predicted to be part of 7SK snRNP. Is expressed in several structures, including adrenal gland; alimentary system; brain; early conceptus; and genitourinary system. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 32.4), thymus adult (RPKM 24.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.7 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137780168..137784963, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137781906..137786701, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C78815 (e-PCR)
- UniSTS:207898

RH125705 (e-PCR)
- UniSTS:142574

Homology

Homologs of the Mepce gene: The Mepce gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, A.thaliana, and rice.
Orthologs from Annotation Pipeline: 282 organisms have orthologs with human gene Mepce
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 7SK snRNA binding	ISO Inferred from Sequence Orthology more info
enables O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA 5'-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables S-adenosylmethionine-dependent methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables snRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of chromatin binding	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to Cajal body	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of snRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in snRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in snRNA modification	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in snRNA modification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of 7SK snRNP	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 7SK snRNA methylphosphate capping enzyme

Names: bin3, bicoid-interacting 3, homolog

NP_659162.3

EC 2.1.1.-

XP_017176362.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144913.3 → NP_659162.3 7SK snRNA methylphosphate capping enzyme

See identical proteins and their annotated locations for NP_659162.3

Status: VALIDATED

Source sequence(s)

AC125063, AK139731, BF323293

Consensus CDS

CCDS39337.1

UniProtKB/Swiss-Prot

Q8K3A9, Q91W35

Related

ENSMUSP00000031740.10, ENSMUST00000031740.16

Conserved Domains (2) summary

cd02440
Location:423 → 593

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam06859
Location:552 → 660

Bin3; Bicoid-interacting protein 3 (Bin3)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

137780168..137784963 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320873.1 → XP_017176362.1 7SK snRNA methylphosphate capping enzyme isoform X1

Conserved Domains (2) summary

cd02440
Location:423 → 593

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam06859
Location:552 → 650

Bin3; Bicoid-interacting protein 3 (Bin3)