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    Agfg2 ArfGAP with FG repeats 2 [ Mus musculus (house mouse) ]

    Gene ID: 231801, updated on 23-Jun-2021

    Summary

    Official Symbol
    Agfg2provided by MGI
    Official Full Name
    ArfGAP with FG repeats 2provided by MGI
    Primary source
    MGI:MGI:2443267
    See related
    Ensembl:ENSMUSG00000029722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hr; Hrbl; RABR; RAB-R; A630095P14Rik
    Summary
    This gene encodes a paralog of the HIV-1 Rev binding proteins that serve as cellular co-factors for HIV-1 Rev protein in shuttling viral pre-mRNAs from the nucleus to the cytoplasm. The encoded protein contains an ADP-ribosylation factor GTPase activating protein (Arf-GAP) zinc finger domain, several phenylalanine-glycine (FG) motifs and asparagine-proline-phenylalanine (NPF) motifs. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in thymus adult (RPKM 56.4), adrenal adult (RPKM 28.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Agfg2 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137648725..137683068, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137650463..137684806, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (138092070..138125921, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20605 Neighboring gene sin3 associated polypeptide Neighboring gene insulin receptor substrate 3 Neighboring gene predicted gene, 54308 Neighboring gene predicted gene 15753 Neighboring gene neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7148, MGC61203

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    arf-GAP domain and FG repeat-containing protein 2
    Names
    HIV-1 Rev-binding protein-like protein
    arf-GAP domain and FG repeats-containing protein 2
    rev/Rex activation domain-binding protein related

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303266.1NP_001290195.1  arf-GAP domain and FG repeat-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001290195.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional in-frame exon in the 3' coding region, compared to variant 2. The resulting protein (isoform 3) is longer than isoform 2.
      Source sequence(s)
      AC124730
      Consensus CDS
      CCDS80443.1
      UniProtKB/TrEMBL
      Q3U2K8
      Related
      ENSMUSP00000098112.5, ENSMUST00000100544.11
      Conserved Domains (1) summary
      cl02464
      Location:40152
      ArfGap; Putative GTPase activating protein for Arf
    2. NM_001303271.1NP_001290200.1  arf-GAP domain and FG repeat-containing protein 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site and contains an additional in-frame exon in the 3' coding region, compared to variant 2. The resulting protein (isoform 4) is longer than isoform 2.
      Source sequence(s)
      AC124730
      Related
      ENSMUSP00000117351.2, ENSMUST00000151839.2
      Conserved Domains (1) summary
      cl02464
      Location:40152
      ArfGap; Putative GTPase activating protein for Arf
    3. NM_178162.3NP_835456.1  arf-GAP domain and FG repeat-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_835456.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the shortest isoform (2).
      Source sequence(s)
      AC124730, BC046788
      Consensus CDS
      CCDS19774.1
      UniProtKB/Swiss-Prot
      Q80WC7
      Related
      ENSMUSP00000031736.10, ENSMUST00000031736.16
      Conserved Domains (1) summary
      cl02464
      Location:40152
      ArfGap; Putative GTPase activating protein for Arf

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137648725..137683068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504570.3XP_006504633.1  arf-GAP domain and FG repeat-containing protein 2 isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:163411
      PHA03247; large tegument protein UL36; Provisional
      cd17903
      Location:30146
      ArfGap_AGFG2; ArfGAP domain of AGFG2 (ArfGAP domain and FG repeat-containing protein 2)
    2. XM_006504569.3XP_006504632.1  arf-GAP domain and FG repeat-containing protein 2 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:146453
      PHA03247; large tegument protein UL36; Provisional
      cd17903
      Location:30146
      ArfGap_AGFG2; ArfGAP domain of AGFG2 (ArfGAP domain and FG repeat-containing protein 2)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145566.1: Suppressed sequence

      Description
      NM_145566.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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