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    Lrch4 leucine-rich repeats and calponin homology (CH) domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 231798, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lrch4provided by MGI
    Official Full Name
    leucine-rich repeats and calponin homology (CH) domain containing 4provided by MGI
    Primary source
    MGI:MGI:1917193
    See related
    Ensembl:ENSMUSG00000093445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LRN; LRRN4; SAP25; AI558103; 2810008P14Rik; 2900069C24Rik
    Expression
    Broad expression in thymus adult (RPKM 109.4), spleen adult (RPKM 73.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Lrch4 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137627385..137639361)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137629123..137641099)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (138070351..138082327)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36266 Neighboring gene F-box protein 24 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene predicted gene 20605 Neighboring gene sin3 associated polypeptide Neighboring gene insulin receptor substrate 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Readthrough Gm20605

    Readthrough gene: Gm20605, Included gene: Sap25

    Homology

    Clone Names

    • MGC19364

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    leucine-rich repeat and calponin homology domain-containing protein 4
    Names
    leucine rich repeat protein 4, neuronal

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168652.1NP_001162123.1  leucine-rich repeat and calponin homology domain-containing protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 3' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      BQ924416, BY204138, CA323124, CF729493, CN702489, DV661712
      Consensus CDS
      CCDS57392.1
      UniProtKB/TrEMBL
      H3BLL3
      Related
      ENSMUSP00000135832.2, ENSMUST00000176667.8
      Conserved Domains (5) summary
      cd00116
      Location:103245
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:4669
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00307
      Location:532627
      CH; Calponin homology (CH) domain
      pfam12799
      Location:92131
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:138194
      LRR_8; Leucine rich repeat
    2. NM_146164.2NP_666276.1  leucine-rich repeat and calponin homology domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_666276.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC124730, BQ924416, BY204138, CF729493, CN702489, CV783140, DV650548, DV661712
      Consensus CDS
      CCDS19772.1
      UniProtKB/Swiss-Prot
      Q921G6
      Related
      ENSMUSP00000031734.10, ENSMUST00000031734.16
      Conserved Domains (6) summary
      cd00116
      Location:103245
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:4669
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00307
      Location:532624
      CH; Calponin homology (CH) domain
      pfam02377
      Location:265405
      Dishevelled; Dishevelled specific domain
      pfam12799
      Location:92131
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:138194
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137627385..137639361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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