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    Sfswap splicing factor SWAP [ Mus musculus (house mouse) ]

    Gene ID: 231769, updated on 2-Oct-2018

    Summary

    Official Symbol
    Sfswapprovided by MGI
    Official Full Name
    splicing factor SWAPprovided by MGI
    Primary source
    MGI:MGI:101760
    See related
    Ensembl:ENSMUSG00000029439 Vega:OTTMUSG00000055315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SWAP; Sfrs8; Srsf8; AI197402; AW212079; 1190005N23Rik; 6330437E22Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 33.7), CNS E14 (RPKM 31.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Sfswap in Genome Data Viewer
    Location:
    5; 5 G1.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (129501231..129571384)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (130007106..130077259)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34468 Neighboring gene predicted gene, 40333 Neighboring gene predicted gene, 40332 Neighboring gene matrix metallopeptidase 17 Neighboring gene 40S ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 5'-splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA 5'-splice site recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    splicing factor, suppressor of white-apricot homolog
    Names
    serine/arginine-rich splicing factor 8
    splicing factor, arginine/serine-rich 8
    suppressor of white apricot protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359952.1NP_001346881.1  splicing factor, suppressor of white-apricot homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC114614, AC114657
      Conserved Domains (1) summary
      smart00648
      Location:83136
      SWAP; Suppressor-of-White-APricot splicing regulator
    2. NM_172276.3NP_758480.2  splicing factor, suppressor of white-apricot homolog isoform 1

      See identical proteins and their annotated locations for NP_758480.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK140369, AW121884, BC057314, BY277733
      Consensus CDS
      CCDS19694.1
      UniProtKB/Swiss-Prot
      Q3USH5
      Related
      ENSMUSP00000062413.7, OTTMUSP00000072184, ENSMUST00000053737.8, OTTMUST00000136925
      Conserved Domains (3) summary
      smart00648
      Location:209262
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam01346
      Location:634674
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
      pfam09750
      Location:35155
      DRY_EERY; Alternative splicing regulator

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      129501231..129571384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240841.2XP_011239143.1  splicing factor, suppressor of white-apricot homolog isoform X4

      See identical proteins and their annotated locations for XP_011239143.1

      Conserved Domains (2) summary
      smart00648
      Location:83136
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam01346
      Location:508548
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
    2. XM_006504303.3XP_006504366.1  splicing factor, suppressor of white-apricot homolog isoform X4

      See identical proteins and their annotated locations for XP_006504366.1

      Conserved Domains (2) summary
      smart00648
      Location:83136
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam01346
      Location:508548
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
    3. XM_006504300.2XP_006504363.1  splicing factor, suppressor of white-apricot homolog isoform X1

      Conserved Domains (3) summary
      smart00648
      Location:209262
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam01346
      Location:634674
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
      pfam09750
      Location:35155
      DRY_EERY; Alternative splicing regulator
    4. XM_006504301.2XP_006504364.1  splicing factor, suppressor of white-apricot homolog isoform X2

      Conserved Domains (3) summary
      smart00648
      Location:209262
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam01346
      Location:606646
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
      pfam09750
      Location:35155
      DRY_EERY; Alternative splicing regulator
    5. XM_006504302.3XP_006504365.1  splicing factor, suppressor of white-apricot homolog isoform X4

      See identical proteins and their annotated locations for XP_006504365.1

      Conserved Domains (2) summary
      smart00648
      Location:83136
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam01346
      Location:508548
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
    6. XM_017320872.1XP_017176361.1  splicing factor, suppressor of white-apricot homolog isoform X5

      Conserved Domains (1) summary
      smart00648
      Location:83136
      SWAP; Suppressor-of-White-APricot splicing regulator
    7. XM_006504305.3XP_006504368.1  splicing factor, suppressor of white-apricot homolog isoform X6

      Conserved Domains (2) summary
      smart00648
      Location:83136
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam01346
      Location:480520
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
    8. XM_011240840.1XP_011239142.1  splicing factor, suppressor of white-apricot homolog isoform X3

      Conserved Domains (3) summary
      smart00648
      Location:209262
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam01346
      Location:606646
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
      pfam09750
      Location:35155
      DRY_EERY; Alternative splicing regulator
    9. XM_006504304.3XP_006504367.1  splicing factor, suppressor of white-apricot homolog isoform X5

      Conserved Domains (1) summary
      smart00648
      Location:83136
      SWAP; Suppressor-of-White-APricot splicing regulator

    RNA

    1. XR_377056.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001035259.1: Suppressed sequence

      Description
      NM_001035259.1: This RefSeq was permanently suppressed because it was primarily intronic sequence.
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