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    Oas1e 2'-5' oligoadenylate synthetase 1E [ Mus musculus (house mouse) ]

    Gene ID: 231699, updated on 31-Aug-2021

    Summary

    Official Symbol
    Oas1eprovided by MGI
    Official Full Name
    2'-5' oligoadenylate synthetase 1Eprovided by MGI
    Primary source
    MGI:MGI:2180856
    See related
    Ensembl:ENSMUSG00000066867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    oasl7; C87484
    Expression
    Biased expression in ovary adult (RPKM 3.8), small intestine adult (RPKM 0.5) and 1 other tissue See more
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    Genomic context

    See Oas1e in Genome Data Viewer
    Location:
    5 F; 5 60.64 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120924377..120933595, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120786312..120795530, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (121236321..121245539, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 2 Neighboring gene 2'-5' oligoadenylate synthetase 3 Neighboring gene 2'-5' oligoadenylate synthetase 1C Neighboring gene 2'-5' oligoadenylate synthetase 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Clone Names

    • MGC124108

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 2'-5'-oligoadenylate synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT enables 2'-5'-oligoadenylate synthetase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of IP-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular respiration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of monocyte chemotactic protein-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in surfactant homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type I interferon signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    2'-5' oligoadenylate synthetase 1E
    Names
    2'-5' oligoadenylate synthetase-like 7
    2'-5'olygoadenylate synthetase 1E
    2,5-oligoadenylate synthetase-like 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347450.1NP_001334379.1  2'-5' oligoadenylate synthetase 1E isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC115937
      Consensus CDS
      CCDS84950.1
      UniProtKB/TrEMBL
      A0A0J9YV76
      Related
      ENSMUSP00000144529.2, ENSMUST00000201172.2
    2. NM_145210.2NP_660211.2  2'-5' oligoadenylate synthetase 1E isoform 2

      See identical proteins and their annotated locations for NP_660211.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK087823, DV662831
      Consensus CDS
      CCDS39243.1
      UniProtKB/TrEMBL
      Q8C2W3
      Related
      ENSMUSP00000098348.4, ENSMUST00000100785.7
      Conserved Domains (2) summary
      cd05400
      Location:27157
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:171353
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      120924377..120933595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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