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    Fbxw8 F-box and WD-40 domain protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 231672, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fbxw8provided by MGI
    Official Full Name
    F-box and WD-40 domain protein 8provided by MGI
    Primary source
    MGI:MGI:1923041
    See related
    Ensembl:ENSMUSG00000032867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBW6; FBW8; FBXO2; Fbx29; FBXO29; 4930438M06Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 39.6), subcutaneous fat pad adult (RPKM 36.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Fbxw8 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118203046..118293523, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (118064981..118155458, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (118514990..118605467, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene F-box protein 21 Neighboring gene tescalcin Neighboring gene predicted gene, 30466 Neighboring gene predicted gene, 26411 Neighboring gene predicted gene, 30522 Neighboring gene harakiri, BCL2 interacting protein (contains only BH3 domain)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of 3M complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul7-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Cul7-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box/WD repeat-containing protein 8
    Names
    F-box and WD-40 domain-containing protein 8
    F-box protein FBX29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172721.2NP_766309.2  F-box/WD repeat-containing protein 8

      See identical proteins and their annotated locations for NP_766309.2

      Status: VALIDATED

      Source sequence(s)
      AK034447, AK053794, BY468586
      Consensus CDS
      CCDS19609.1
      UniProtKB/Swiss-Prot
      Q8BIA4
      Related
      ENSMUSP00000047012.8, ENSMUST00000049474.9
      Conserved Domains (4) summary
      COG2319
      Location:263588
      WD40; WD40 repeat [General function prediction only]
      pfam12937
      Location:118162
      F-box-like; F-box-like
      sd00039
      Location:213252
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:209501
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      118203046..118293523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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