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    Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase [ Mus musculus (house mouse) ]

    Gene ID: 231642, updated on 31-Jan-2019

    Summary

    Official Symbol
    Alkbh2provided by MGI
    Official Full Name
    alkB homolog 2, alpha-ketoglutarate-dependent dioxygenaseprovided by MGI
    Primary source
    MGI:MGI:2141032
    See related
    Ensembl:ENSMUSG00000044339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abh2; mABH2; AU016977; 9530023G02
    Expression
    Ubiquitous expression in ovary adult (RPKM 4.9), CNS E11.5 (RPKM 4.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Alkbh2 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (114123926..114130544, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (114573943..114578185, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene SV2 related protein Neighboring gene predicted gene 16108 Neighboring gene ubiquitin specific peptidase 30 Neighboring gene legumain pseudogene Neighboring gene uracil DNA glycosylase Neighboring gene acetyl-Coenzyme A carboxylase beta Neighboring gene forkhead box N4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    1-ethyladenine demethylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-N1-methyladenine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-N1-methyladenine dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytosine C-5 DNA demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosine C-5 DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosine C-5 DNA demethylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA dealkylation involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA dealkylation involved in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidative DNA demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidative DNA demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA oxidative demethylase ALKBH2
    Names
    alkB, alkylation repair homolog 2
    alkylated DNA repair protein alkB homolog 2
    alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
    NP_778181.2
    XP_006530352.1
    XP_006530353.1
    XP_006530354.1
    XP_006530355.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359940.1NP_001346869.1  DNA oxidative demethylase ALKBH2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC129080, AK079195, BG083657, BY210211
      Conserved Domains (1) summary
      pfam13532
      Location:50232
      2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily
    2. NM_001359941.1NP_001346870.1  DNA oxidative demethylase ALKBH2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC129080, AK079195, BG083657
      Conserved Domains (1) summary
      pfam13532
      Location:50232
      2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily
    3. NM_175016.3NP_778181.2  DNA oxidative demethylase ALKBH2

      See identical proteins and their annotated locations for NP_778181.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AK079195, BC062188, BG083657
      Consensus CDS
      CCDS19559.1
      UniProtKB/Swiss-Prot
      Q6P6J4
      Related
      ENSMUSP00000056043.6, ENSMUST00000053657.12
      Conserved Domains (1) summary
      pfam13532
      Location:50232
      2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      114123926..114130544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530290.3XP_006530353.1  DNA oxidative demethylase ALKBH2 isoform X1

      See identical proteins and their annotated locations for XP_006530353.1

      UniProtKB/Swiss-Prot
      Q6P6J4
      Conserved Domains (1) summary
      pfam13532
      Location:50232
      2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily
    2. XM_006530292.3XP_006530355.1  DNA oxidative demethylase ALKBH2 isoform X1

      See identical proteins and their annotated locations for XP_006530355.1

      UniProtKB/Swiss-Prot
      Q6P6J4
      Conserved Domains (1) summary
      pfam13532
      Location:50232
      2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily
    3. XM_006530291.2XP_006530354.1  DNA oxidative demethylase ALKBH2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P6J4
      Conserved Domains (1) summary
      pfam13532
      Location:50232
      2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily
    4. XM_006530289.3XP_006530352.1  DNA oxidative demethylase ALKBH2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P6J4
      Related
      ENSMUSP00000107898.1, ENSMUST00000112279.1
      Conserved Domains (1) summary
      pfam13532
      Location:50232
      2OG-FeII_Oxy_2; 2OG-Fe(II) oxygenase superfamily
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