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    Chfr checkpoint with forkhead and ring finger domains [ Mus musculus (house mouse) ]

    Gene ID: 231600, updated on 23-Jun-2021

    Summary

    Official Symbol
    Chfrprovided by MGI
    Official Full Name
    checkpoint with forkhead and ring finger domainsprovided by MGI
    Primary source
    MGI:MGI:2444898
    See related
    Ensembl:ENSMUSG00000014668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNF1; RNF116; C230082M18; 5730484M20Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 17.7), CNS E14 (RPKM 15.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Chfr in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110283599..110319839)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110135755..110171973)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (110564859..110600991)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 1 Neighboring gene GTP binding protein 6 (putative) Neighboring gene zinc finger protein 605 Neighboring gene nucleophosmin pseudogene Neighboring gene predicted gene 15787 Neighboring gene golgi autoantigen, golgin subfamily a, 3 Neighboring gene uncharacterized LOC118568795 Neighboring gene ankyrin repeat and LEM domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiotic spindle checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2/M transition checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic cell cycle checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in modification-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase CHFR
    Names
    RING-type E3 ubiquitin transferase CHFR
    NP_001276506.1
    NP_001276507.1
    NP_001276508.1
    NP_001276509.1
    NP_766305.2
    XP_011247747.1
    XP_011247748.1
    XP_030110278.1
    XP_030110279.1
    XP_030110280.1
    XP_036020978.1
    XP_036020979.1
    XP_036020980.1
    XP_036020981.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289577.1NP_001276506.1  E3 ubiquitin-protein ligase CHFR isoform 1

      See identical proteins and their annotated locations for NP_001276506.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC118260
      Consensus CDS
      CCDS71637.1
      UniProtKB/Swiss-Prot
      Q810L3
      Related
      ENSMUSP00000108138.3, ENSMUST00000112519.9
      Conserved Domains (3) summary
      COG1716
      Location:27140
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:16105
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00162
      Location:302345
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_001289578.1NP_001276507.1  E3 ubiquitin-protein ligase CHFR isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC118260, AK147892
      Consensus CDS
      CCDS80358.1
      UniProtKB/Swiss-Prot
      Q810L3
      Related
      ENSMUSP00000143480.2, ENSMUST00000198633.5
      Conserved Domains (3) summary
      COG1716
      Location:27103
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:16105
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00162
      Location:230273
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. NM_001289579.1NP_001276508.1  E3 ubiquitin-protein ligase CHFR isoform 4

      See identical proteins and their annotated locations for NP_001276508.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC118260, AK169182
      UniProtKB/Swiss-Prot
      Q810L3
      Conserved Domains (3) summary
      TIGR00599
      Location:139362
      rad18; DNA repair protein rad18
      cd16503
      Location:159202
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:326480
      zf-CRD; Cysteine rich domain with multizinc binding regions
    4. NM_001289580.1NP_001276509.1  E3 ubiquitin-protein ligase CHFR isoform 5

      See identical proteins and their annotated locations for NP_001276509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in the 5' region, uses an alternate in-frame splice site, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC118260, AK048930, AK169182
      UniProtKB/Swiss-Prot
      Q810L3
      Conserved Domains (3) summary
      TIGR00599
      Location:139361
      rad18; DNA repair protein rad18
      cd16503
      Location:159202
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:326479
      zf-CRD; Cysteine rich domain with multizinc binding regions
    5. NM_172717.4NP_766305.2  E3 ubiquitin-protein ligase CHFR isoform 2

      See identical proteins and their annotated locations for NP_766305.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC118260, AK077629
      Consensus CDS
      CCDS19522.1
      UniProtKB/Swiss-Prot
      Q810L3
      Related
      ENSMUSP00000014812.9, ENSMUST00000014812.13
      Conserved Domains (3) summary
      COG1716
      Location:27140
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:16105
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00162
      Location:302345
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110283599..110319839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254418.2XP_030110278.1  E3 ubiquitin-protein ligase CHFR isoform X3

      Conserved Domains (3) summary
      TIGR00599
      Location:139361
      rad18; DNA repair protein rad18
      cd16503
      Location:159202
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:326479
      zf-CRD; Cysteine rich domain with multizinc binding regions
    2. XM_011249445.3XP_011247747.1  E3 ubiquitin-protein ligase CHFR isoform X2

      See identical proteins and their annotated locations for XP_011247747.1

      UniProtKB/Swiss-Prot
      Q810L3
      Conserved Domains (3) summary
      TIGR00599
      Location:139362
      rad18; DNA repair protein rad18
      cd16503
      Location:159202
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:326480
      zf-CRD; Cysteine rich domain with multizinc binding regions
    3. XM_011249446.3XP_011247748.1  E3 ubiquitin-protein ligase CHFR isoform X2

      See identical proteins and their annotated locations for XP_011247748.1

      UniProtKB/Swiss-Prot
      Q810L3
      Conserved Domains (3) summary
      TIGR00599
      Location:139362
      rad18; DNA repair protein rad18
      cd16503
      Location:159202
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:326480
      zf-CRD; Cysteine rich domain with multizinc binding regions
    4. XM_036165087.1XP_036020980.1  E3 ubiquitin-protein ligase CHFR isoform X3

      Conserved Domains (3) summary
      TIGR00599
      Location:139361
      rad18; DNA repair protein rad18
      cd16503
      Location:159202
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:326479
      zf-CRD; Cysteine rich domain with multizinc binding regions
    5. XM_030254419.2XP_030110279.1  E3 ubiquitin-protein ligase CHFR isoform X3

      Conserved Domains (3) summary
      TIGR00599
      Location:139361
      rad18; DNA repair protein rad18
      cd16503
      Location:159202
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:326479
      zf-CRD; Cysteine rich domain with multizinc binding regions
    6. XM_036165085.1XP_036020978.1  E3 ubiquitin-protein ligase CHFR isoform X1

      Conserved Domains (4) summary
      cd00060
      Location:558
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR00599
      Location:232455
      rad18; DNA repair protein rad18
      cd16503
      Location:252295
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:419573
      zf-CRD; Cysteine rich domain with multizinc binding regions
    7. XM_030254420.2XP_030110280.1  E3 ubiquitin-protein ligase CHFR isoform X4

      Conserved Domains (3) summary
      TIGR00599
      Location:1206
      rad18; DNA repair protein rad18
      cd16503
      Location:346
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:170324
      zf-CRD; Cysteine rich domain with multizinc binding regions
    8. XM_036165088.1XP_036020981.1  E3 ubiquitin-protein ligase CHFR isoform X4

      Conserved Domains (3) summary
      TIGR00599
      Location:1206
      rad18; DNA repair protein rad18
      cd16503
      Location:346
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:170324
      zf-CRD; Cysteine rich domain with multizinc binding regions
    9. XM_036165086.1XP_036020979.1  E3 ubiquitin-protein ligase CHFR isoform X2

      Conserved Domains (3) summary
      TIGR00599
      Location:139362
      rad18; DNA repair protein rad18
      cd16503
      Location:159202
      RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
      pfam17979
      Location:326480
      zf-CRD; Cysteine rich domain with multizinc binding regions

    RNA

    1. XR_001784679.2 RNA Sequence

      Related
      ENSMUST00000198066.5
    2. XR_004942506.1 RNA Sequence

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