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    Chfr checkpoint with forkhead and ring finger domains [ Mus musculus (house mouse) ]

    Gene ID: 231600, updated on 5-Aug-2018

    Summary

    Official Symbol
    Chfrprovided by MGI
    Official Full Name
    checkpoint with forkhead and ring finger domainsprovided by MGI
    Primary source
    MGI:MGI:2444898
    See related
    Ensembl:ENSMUSG00000014668 Vega:OTTMUSG00000054048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNF116; C230082M18; 5730484M20Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 17.7), CNS E14 (RPKM 15.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Chfr in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (110135755..110171973)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (110564859..110600991)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 1 Neighboring gene GTP binding protein 6 (putative) Neighboring gene nucleophosmin pseudogene Neighboring gene zinc finger protein 605 Neighboring gene predicted gene 15787 Neighboring gene golgi autoantigen, golgin subfamily a, 3 Neighboring gene uncharacterized LOC105246962

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cell cycle checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    modification-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase CHFR
    Names
    RING-type E3 ubiquitin transferase CHFR
    NP_001276506.1
    NP_001276507.1
    NP_001276508.1
    NP_001276509.1
    NP_766305.2
    XP_006534978.1
    XP_011247747.1
    XP_011247748.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289577.1NP_001276506.1  E3 ubiquitin-protein ligase CHFR isoform 1

      See identical proteins and their annotated locations for NP_001276506.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC118260
      Consensus CDS
      CCDS71637.1
      UniProtKB/Swiss-Prot
      Q810L3
      Related
      ENSMUSP00000108138.2, OTTMUSP00000071250, ENSMUST00000112519.8, OTTMUST00000134329
      Conserved Domains (3) summary
      COG1716
      Location:27140
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:16105
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00162
      Location:302345
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_001289578.1NP_001276507.1  E3 ubiquitin-protein ligase CHFR isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC118260, AK147892
      Consensus CDS
      CCDS80358.1
      UniProtKB/Swiss-Prot
      Q810L3
      Related
      ENSMUSP00000143480.1, OTTMUSP00000071275, ENSMUST00000198633.4, OTTMUST00000134404
      Conserved Domains (3) summary
      COG1716
      Location:27103
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:16105
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00162
      Location:230273
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. NM_001289579.1NP_001276508.1  E3 ubiquitin-protein ligase CHFR isoform 4

      See identical proteins and their annotated locations for NP_001276508.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC118260, AK169182
      UniProtKB/Swiss-Prot
      Q810L3
      Conserved Domains (1) summary
      cd00162
      Location:162205
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    4. NM_001289580.1NP_001276509.1  E3 ubiquitin-protein ligase CHFR isoform 5

      See identical proteins and their annotated locations for NP_001276509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in the 5' region, uses an alternate in-frame splice site, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC118260, AK048930, AK169182
      UniProtKB/Swiss-Prot
      Q810L3
      Conserved Domains (1) summary
      cd00162
      Location:162205
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    5. NM_172717.4NP_766305.2  E3 ubiquitin-protein ligase CHFR isoform 2

      See identical proteins and their annotated locations for NP_766305.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC118260, AK077629
      Consensus CDS
      CCDS19522.1
      UniProtKB/Swiss-Prot
      Q810L3
      Related
      ENSMUSP00000014812.8, OTTMUSP00000071276, ENSMUST00000014812.12, OTTMUST00000134406
      Conserved Domains (3) summary
      COG1716
      Location:27140
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:16105
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00162
      Location:302345
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      110135755..110171973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249445.2XP_011247747.1  E3 ubiquitin-protein ligase CHFR isoform X2

      See identical proteins and their annotated locations for XP_011247747.1

      UniProtKB/Swiss-Prot
      Q810L3
      Conserved Domains (1) summary
      cd00162
      Location:162205
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. XM_011249446.2XP_011247748.1  E3 ubiquitin-protein ligase CHFR isoform X2

      See identical proteins and their annotated locations for XP_011247748.1

      UniProtKB/Swiss-Prot
      Q810L3
      Conserved Domains (1) summary
      cd00162
      Location:162205
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. XM_006534915.1XP_006534978.1  E3 ubiquitin-protein ligase CHFR isoform X1

      Conserved Domains (3) summary
      COG1716
      Location:293
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:558
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00162
      Location:255298
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RNA

    1. XR_001784680.1 RNA Sequence

    2. XR_001784679.1 RNA Sequence

      Related
      ENSMUST00000198066.4, OTTMUST00000134407
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