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    WDR43 WD repeat domain 43 [ Homo sapiens (human) ]

    Gene ID: 23160, updated on 5-Mar-2024

    Summary

    Official Symbol
    WDR43provided by HGNC
    Official Full Name
    WD repeat domain 43provided by HGNC
    Primary source
    HGNC:HGNC:28945
    See related
    Ensembl:ENSG00000163811 MIM:616195; AllianceGenome:HGNC:28945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UTP5; NET12
    Summary
    Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 11.4), appendix (RPKM 11.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See WDR43 in Genome Data Viewer
    Location:
    2p23.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (28894667..28948219)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (28938252..28991773)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (29117533..29171085)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene PPP1CB divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:28974622-28975266 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:28978040-28978253 Neighboring gene protein phosphatase 1 catalytic subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11314 Neighboring gene speedy/RINGO cell cycle regulator family member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29091169-29091684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29091685-29092199 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29092829-29093353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15527 Neighboring gene tRNA methyltransferase 61B Neighboring gene ReSE screen-validated silencer GRCh37_chr2:29105260-29105423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11315 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29117677-29118300 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29118301-29118922 Neighboring gene small nucleolar RNA, C/D box 92 Neighboring gene small nucleolar RNA, C/D box 53B Neighboring gene small nucleolar RNA, C/D box 53 Neighboring gene TOG array regulator of axonemal microtubules 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29246593-29247094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:29264781-29265402 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:29275821-29276331 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29285737-29286651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29287995-29288677 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29289979-29290479 Neighboring gene photoreceptor cilium actin regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA polymerase II complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat-containing protein 43
    Names
    U3 small nucleolar RNA-associated protein 5 homolog
    UTP5, small subunit (SSU) processome component, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015131.3NP_055946.1  WD repeat-containing protein 43

      See identical proteins and their annotated locations for NP_055946.1

      Status: VALIDATED

      Source sequence(s)
      AC097720, AW593733, D26488, DA654485
      Consensus CDS
      CCDS46251.1
      UniProtKB/Swiss-Prot
      Q15061, Q15395, Q92577
      Related
      ENSP00000384302.3, ENST00000407426.8
      Conserved Domains (4) summary
      COG2319
      Location:19217
      WD40; WD40 repeat [General function prediction only]
      pfam04003
      Location:474570
      Utp12; Dip2/Utp12 Family
      sd00039
      Location:1957
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:19272
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      28894667..28948219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      28938252..28991773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)