Format

Send to:

Choose Destination
    • Showing Current items.

    Gak cyclin G associated kinase [ Mus musculus (house mouse) ]

    Gene ID: 231580, updated on 5-Sep-2021

    Summary

    Official Symbol
    Gakprovided by MGI
    Official Full Name
    cyclin G associated kinaseprovided by MGI
    Primary source
    MGI:MGI:2442153
    See related
    Ensembl:ENSMUSG00000062234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D130045N16Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 34.6), large intestine adult (RPKM 29.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gak in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108716973..108777643, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108569107..108629777, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108998433..109058758, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L34 pseudogene Neighboring gene complexin 1 Neighboring gene transmembrane protein 175 Neighboring gene diacylglycerol kinase, theta Neighboring gene iduronidase, alpha-L Neighboring gene solute carrier family 26 (sulfate transporter), member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC31204, D130045N16Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in clathrin coat disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within clathrin coat disassembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in clathrin coat disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin-coated pit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intrahepatic bile duct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-G-associated kinase
    NP_001268980.1
    NP_001268981.1
    NP_001346851.1
    NP_001346852.1
    NP_001346853.1
    NP_705797.1
    XP_006534968.1
    XP_036020971.1
    XP_036020972.1
    XP_036020973.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282051.1NP_001268980.1  cyclin-G-associated kinase isoform 2

      See identical proteins and their annotated locations for NP_001268980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
      Source sequence(s)
      AC133896, AI466057, AK166682, BC065109, BY312464
      UniProtKB/Swiss-Prot
      Q99KY4
      Conserved Domains (4) summary
      cd06257
      Location:10921137
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:5521008
      Atrophin-1; Atrophin-1 family
    2. NM_001282052.1NP_001268981.1  cyclin-G-associated kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC133896, AI466057, AK166682, BC062975, BY312464
      UniProtKB/Swiss-Prot
      Q99KY4
      Conserved Domains (3) summary
      cd06257
      Location:10411086
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:356494
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:1108
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001359922.1NP_001346851.1  cyclin-G-associated kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC133896, AC161813
      Conserved Domains (5) summary
      cd06257
      Location:10431088
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:777930
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:631964
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    4. NM_001359923.1NP_001346852.1  cyclin-G-associated kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161813, AK051394
      Related
      ENSMUST00000137872.8
      Conserved Domains (2) summary
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001359924.1NP_001346853.1  cyclin-G-associated kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC133896, AC161813, AK150112
      Conserved Domains (4) summary
      cd06257
      Location:10921137
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:5521008
      Atrophin-1; Atrophin-1 family
    6. NM_153569.2NP_705797.1  cyclin-G-associated kinase isoform 1

      See identical proteins and their annotated locations for NP_705797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC133896, AI466057, AK166682, BY312464
      Consensus CDS
      CCDS19513.1
      UniProtKB/Swiss-Prot
      Q99KY4
      UniProtKB/TrEMBL
      A0A0R4J0F6
      Related
      ENSMUSP00000036705.9, ENSMUST00000046603.15
      Conserved Domains (4) summary
      cd06257
      Location:12531298
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:568706
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108716973..108777643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534905.4XP_006534968.1  cyclin-G-associated kinase isoform X1

      Conserved Domains (5) summary
      cd06257
      Location:12041249
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PHA03247
      Location:9381091
      PHA03247; large tegument protein UL36; Provisional
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      cd14564
      Location:398560
      PTP_GAK; protein tyrosine phosphatase-like domain of cyclin-G-associated kinase
      pfam10409
      Location:568706
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    2. XM_036165079.1XP_036020972.1  cyclin-G-associated kinase isoform X2

      Conserved Domains (3) summary
      cd06257
      Location:774819
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PHA03247
      Location:234690
      PHA03247; large tegument protein UL36; Provisional
      pfam10409
      Location:89227
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    3. XM_036165078.1XP_036020971.1  cyclin-G-associated kinase isoform X2

      Conserved Domains (3) summary
      cd06257
      Location:774819
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PHA03247
      Location:234690
      PHA03247; large tegument protein UL36; Provisional
      pfam10409
      Location:89227
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    4. XM_036165080.1XP_036020973.1  cyclin-G-associated kinase isoform X3

      Conserved Domains (3) summary
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      cd14564
      Location:398560
      PTP_GAK; protein tyrosine phosphatase-like domain of cyclin-G-associated kinase
      pfam10409
      Location:568683
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    RNA

    1. XR_003955633.2 RNA Sequence

    2. XR_389271.5 RNA Sequence

      Related
      ENSMUST00000135225.8
    3. XR_001784677.3 RNA Sequence

      Related
      ENSMUST00000199048.5
    4. XR_004942505.1 RNA Sequence

    Support Center