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    Gak cyclin G associated kinase [ Mus musculus (house mouse) ]

    Gene ID: 231580, updated on 31-Jan-2019

    Summary

    Official Symbol
    Gakprovided by MGI
    Official Full Name
    cyclin G associated kinaseprovided by MGI
    Primary source
    MGI:MGI:2442153
    See related
    Ensembl:ENSMUSG00000062234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D130045N16Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 34.6), large intestine adult (RPKM 29.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gak in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (108569107..108629777, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108998433..109058758, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L34 pseudogene Neighboring gene complexin 1 Neighboring gene transmembrane protein 175 Neighboring gene diacylglycerol kinase, theta Neighboring gene iduronidase, alpha-L Neighboring gene solute carrier family 26 (sulfate transporter), member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC31204, D130045N16Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    clathrin coat disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    clathrin coat disassembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    clathrin coat disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated pit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrahepatic bile duct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-G-associated kinase
    NP_001268980.1
    NP_001268981.1
    NP_705797.1
    XP_006534968.1
    XP_006534970.1
    XP_017176342.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282051.1NP_001268980.1  cyclin-G-associated kinase isoform 2

      See identical proteins and their annotated locations for NP_001268980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
      Source sequence(s)
      AC133896, AI466057, AK166682, BC065109, BY312464
      UniProtKB/Swiss-Prot
      Q99KY4
      Conserved Domains (4) summary
      cd06257
      Location:10921137
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:5521008
      Atrophin-1; Atrophin-1 family
    2. NM_001282052.1NP_001268981.1  cyclin-G-associated kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC133896, AI466057, AK166682, BC062975, BY312464
      UniProtKB/Swiss-Prot
      Q99KY4
      Conserved Domains (3) summary
      cd06257
      Location:10411086
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:356494
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:1108
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001359922.1NP_001346851.1  cyclin-G-associated kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC133896, AC161813
      Conserved Domains (5) summary
      cd06257
      Location:10431088
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:777930
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:631964
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    4. NM_001359923.1NP_001346852.1  cyclin-G-associated kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161813, AK051394
      Conserved Domains (2) summary
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001359924.1NP_001346853.1  cyclin-G-associated kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC133896, AC161813, AK150112
      Conserved Domains (4) summary
      cd06257
      Location:10921137
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:5521008
      Atrophin-1; Atrophin-1 family
    6. NM_153569.2NP_705797.1  cyclin-G-associated kinase isoform 1

      See identical proteins and their annotated locations for NP_705797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC133896, AI466057, AK166682, BY312464
      Consensus CDS
      CCDS19513.1
      UniProtKB/Swiss-Prot
      Q99KY4
      UniProtKB/TrEMBL
      A0A0R4J0F6
      Related
      ENSMUSP00000036705.8, ENSMUST00000046603.14
      Conserved Domains (4) summary
      cd06257
      Location:12531298
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:568706
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      108569107..108629777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534905.2XP_006534968.1  cyclin-G-associated kinase isoform X1

      Conserved Domains (4) summary
      cd06257
      Location:12041249
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:568706
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    2. XM_006534907.3XP_006534970.1  cyclin-G-associated kinase isoform X2

      Conserved Domains (4) summary
      cd06257
      Location:10921137
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:5521008
      Atrophin-1; Atrophin-1 family
    3. XM_017320853.1XP_017176342.1  cyclin-G-associated kinase isoform X3

      Conserved Domains (5) summary
      cd06257
      Location:10431088
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:777930
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:631964
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    RNA

    1. XR_389271.3 RNA Sequence

      Related
      ENSMUST00000135225.7
    2. XR_001784677.1 RNA Sequence

      Related
      ENSMUST00000199048.4
    3. XR_001784678.1 RNA Sequence

    4. XR_880392.2 RNA Sequence

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