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    Lin54 lin-54 DREAM MuvB core complex component [ Mus musculus (house mouse) ]

    Gene ID: 231506, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lin54provided by MGI
    Official Full Name
    lin-54 DREAM MuvB core complex componentprovided by MGI
    Primary source
    MGI:MGI:2140902
    See related
    Ensembl:ENSMUSG00000118665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI461788
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.3), liver E14 (RPKM 4.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lin54 in Genome Data Viewer
    Location:
    5; 5 E4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100589892..100648506, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100442033..100500639, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (100871052..100929658, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Sec31 homolog A (S. cerevisiae) Neighboring gene RIKEN cDNA 5430416N02 gene Neighboring gene predicted gene, 19620 Neighboring gene COP9 signalosome subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA2037, 4832414L08

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables minor groove of adenine-thymine-rich DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription regulatory region nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    protein lin-54 homolog
    Names
    lin-54 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115010.1NP_001108482.1  protein lin-54 homolog isoform 1

      See identical proteins and their annotated locations for NP_001108482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AC107744, AK030894, AK134320, AK220225
      Consensus CDS
      CCDS19462.2
      UniProtKB/Swiss-Prot
      Q571G4
      Related
      ENSMUSP00000159392.2, ENSMUST00000239513.1
      Conserved Domains (2) summary
      PHA03247
      Location:165499
      PHA03247; large tegument protein UL36; Provisional
      pfam03638
      Location:597631
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
    2. NM_001346583.2NP_001333512.1  protein lin-54 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AC107744, AC109196, MG954270
      Consensus CDS
      CCDS84919.1
      UniProtKB/TrEMBL
      E9PV28
      Conserved Domains (2) summary
      PHA03247
      Location:5278
      PHA03247; large tegument protein UL36; Provisional
      pfam03638
      Location:376410
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
    3. NM_001359914.2NP_001346843.1  protein lin-54 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC107744, AC109196, MG954270
      Conserved Domains (1) summary
      pfam03638
      Location:266301
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
    4. NM_172714.5NP_766302.2  protein lin-54 homolog isoform 1

      See identical proteins and their annotated locations for NP_766302.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AC107744, AC109196, MG954270
      Consensus CDS
      CCDS19462.2
      UniProtKB/Swiss-Prot
      Q571G4
      Related
      ENSMUSP00000159391.2, ENSMUST00000239512.1
      Conserved Domains (2) summary
      PHA03247
      Location:165499
      PHA03247; large tegument protein UL36; Provisional
      pfam03638
      Location:597631
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      100589892..100648506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534883.5XP_006534946.1  protein lin-54 homolog isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:183517
      PHA03247; large tegument protein UL36; Provisional
      pfam03638
      Location:615649
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
    2. XM_017320848.3XP_017176337.1  protein lin-54 homolog isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:23296
      PHA03247; large tegument protein UL36; Provisional
      pfam03638
      Location:394428
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
    3. XM_006534884.5XP_006534947.1  protein lin-54 homolog isoform X2

      See identical proteins and their annotated locations for XP_006534947.1

      UniProtKB/Swiss-Prot
      Q571G4
      Conserved Domains (2) summary
      PHA03247
      Location:165499
      PHA03247; large tegument protein UL36; Provisional
      pfam03638
      Location:597631
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
    4. XM_011249429.4XP_011247731.1  protein lin-54 homolog isoform X4

      See identical proteins and their annotated locations for XP_011247731.1

      UniProtKB/TrEMBL
      E9PV28
      Conserved Domains (2) summary
      PHA03247
      Location:5278
      PHA03247; large tegument protein UL36; Provisional
      pfam03638
      Location:376410
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
    5. XM_011249428.3XP_011247730.1  protein lin-54 homolog isoform X4

      See identical proteins and their annotated locations for XP_011247730.1

      UniProtKB/TrEMBL
      E9PV28
      Conserved Domains (2) summary
      PHA03247
      Location:5278
      PHA03247; large tegument protein UL36; Provisional
      pfam03638
      Location:376410
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
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