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    Cnot6l CCR4-NOT transcription complex, subunit 6-like [ Mus musculus (house mouse) ]

    Gene ID: 231464, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cnot6lprovided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 6-likeprovided by MGI
    Primary source
    MGI:MGI:2443154
    See related
    Ensembl:ENSMUSG00000034724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932442K20Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 4.5), bladder adult (RPKM 3.7) and 27 other tissues See more
    Orthologs

    Genomic context

    See Cnot6l in Genome Data Viewer
    Location:
    5; 5 E3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (96070333..96164314, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (96504756..96591009, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 13 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene predicted gene, 33050

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29037, DKFZp434K098

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A)-specific ribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytoplasmic mRNA processing body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 6-like
    NP_001272440.1
    NP_001272443.1
    NP_659159.1
    NP_849185.2
    XP_006534933.1
    XP_006534934.1
    XP_006534935.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285511.1NP_001272440.1  CCR4-NOT transcription complex subunit 6-like isoform 1

      See identical proteins and their annotated locations for NP_001272440.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (1), which is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC129600, AK030112, AK151728
      Consensus CDS
      CCDS19448.1
      UniProtKB/Swiss-Prot
      Q8VEG6
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    2. NM_001285514.1NP_001272443.1  CCR4-NOT transcription complex subunit 6-like isoform 3

      See identical proteins and their annotated locations for NP_001272443.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 2.
      Source sequence(s)
      AC129600, AK030112, AK151728
      UniProtKB/Swiss-Prot
      Q8VEG6
      Conserved Domains (3) summary
      cd10312
      Location:91438
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:383
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:426
      LRR_RI; leucine-rich repeat [structural motif]
    3. NM_144910.2NP_659159.1  CCR4-NOT transcription complex subunit 6-like isoform 1

      See identical proteins and their annotated locations for NP_659159.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (1), which is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC129600, AK030112, AK151728, BC018506, CF173938
      Consensus CDS
      CCDS19448.1
      UniProtKB/Swiss-Prot
      Q8VEG6
      Related
      ENSMUSP00000119415.1, ENSMUST00000155901.7
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    4. NM_178854.4NP_849185.2  CCR4-NOT transcription complex subunit 6-like isoform 2

      See identical proteins and their annotated locations for NP_849185.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AC129600, AK030112, AK151728
      Consensus CDS
      CCDS51566.1
      UniProtKB/Swiss-Prot
      Q8VEG6
      Related
      ENSMUSP00000108629.2, ENSMUST00000113005.8
      Conserved Domains (3) summary
      cd10312
      Location:191538
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3857
      LRR_1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      96070333..96164314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534870.3XP_006534933.1  CCR4-NOT transcription complex subunit 6-like isoform X1

      See identical proteins and their annotated locations for XP_006534933.1

      UniProtKB/Swiss-Prot
      Q8VEG6
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    2. XM_006534871.1XP_006534934.1  CCR4-NOT transcription complex subunit 6-like isoform X1

      See identical proteins and their annotated locations for XP_006534934.1

      UniProtKB/Swiss-Prot
      Q8VEG6
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    3. XM_006534872.3XP_006534935.1  CCR4-NOT transcription complex subunit 6-like isoform X2

      Conserved Domains (1) summary
      cd10312
      Location:50397
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
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