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    Cnot6l CCR4-NOT transcription complex, subunit 6-like [ Mus musculus (house mouse) ]

    Gene ID: 231464, updated on 3-Aug-2021

    Summary

    Official Symbol
    Cnot6lprovided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 6-likeprovided by MGI
    Primary source
    MGI:MGI:2443154
    See related
    Ensembl:ENSMUSG00000034724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932442K20Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 4.5), bladder adult (RPKM 3.7) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cnot6l in Genome Data Viewer
    Location:
    5; 5 E3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (96218192..96312044, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (96070333..96164198, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (96504756..96591009, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 13 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene predicted gene, 33050

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29037, DKFZp434K098

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-exoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly(A)-specific ribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 6-like
    NP_001272440.1
    NP_001272443.1
    NP_659159.1
    NP_849185.2
    XP_006534933.1
    XP_006534934.1
    XP_006534935.1
    XP_030110258.1
    XP_030110259.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285511.1NP_001272440.1  CCR4-NOT transcription complex subunit 6-like isoform 1

      See identical proteins and their annotated locations for NP_001272440.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (1), which is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC129600, AK030112, AK151728
      Consensus CDS
      CCDS19448.1
      UniProtKB/Swiss-Prot
      Q8VEG6
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    2. NM_001285514.1NP_001272443.1  CCR4-NOT transcription complex subunit 6-like isoform 3

      See identical proteins and their annotated locations for NP_001272443.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 2.
      Source sequence(s)
      AC129600, AK030112, AK151728
      UniProtKB/Swiss-Prot
      Q8VEG6
      Conserved Domains (2) summary
      cd10312
      Location:91438
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:383
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
    3. NM_144910.2NP_659159.1  CCR4-NOT transcription complex subunit 6-like isoform 1

      See identical proteins and their annotated locations for NP_659159.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (1), which is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC129600, AK030112, AK151728, BC018506, CF173938
      Consensus CDS
      CCDS19448.1
      UniProtKB/Swiss-Prot
      Q8VEG6
      Related
      ENSMUSP00000119415.2, ENSMUST00000155901.8
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    4. NM_178854.4NP_849185.2  CCR4-NOT transcription complex subunit 6-like isoform 2

      See identical proteins and their annotated locations for NP_849185.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AC129600, AK030112, AK151728
      Consensus CDS
      CCDS51566.1
      UniProtKB/Swiss-Prot
      Q8VEG6
      Related
      ENSMUSP00000108629.3, ENSMUST00000113005.9
      Conserved Domains (3) summary
      cd10312
      Location:191538
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3857
      LRR_1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      96218192..96312044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534870.5XP_006534933.1  CCR4-NOT transcription complex subunit 6-like isoform X1

      See identical proteins and their annotated locations for XP_006534933.1

      UniProtKB/Swiss-Prot
      Q8VEG6
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    2. XM_030254398.1XP_030110258.1  CCR4-NOT transcription complex subunit 6-like isoform X2

      Conserved Domains (2) summary
      cd10312
      Location:91438
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:383
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
    3. XM_006534871.3XP_006534934.1  CCR4-NOT transcription complex subunit 6-like isoform X1

      See identical proteins and their annotated locations for XP_006534934.1

      UniProtKB/Swiss-Prot
      Q8VEG6
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    4. XM_030254399.2XP_030110259.1  CCR4-NOT transcription complex subunit 6-like isoform X2

      Conserved Domains (2) summary
      cd10312
      Location:91438
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:383
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
    5. XM_006534872.4XP_006534935.1  CCR4-NOT transcription complex subunit 6-like isoform X3

      Conserved Domains (1) summary
      cd10312
      Location:50397
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
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