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    Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 231086, updated on 31-Jan-2019

    Summary

    Official Symbol
    Hadhbprovided by MGI
    Official Full Name
    hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunitprovided by MGI
    Primary source
    MGI:MGI:2136381
    See related
    Ensembl:ENSMUSG00000059447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtpb; TP-beta; 4930479F15Rik
    Expression
    Broad expression in heart adult (RPKM 131.2), liver E18 (RPKM 32.5) and 15 other tissues See more
    Orthologs

    Genomic context

    See Hadhb in Genome Data Viewer
    Location:
    5; 5 B1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (30155253..30184593)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (30481862..30511123)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110082J24 gene Neighboring gene GRB2 associated regulator of MAPK1 subtype 2 Neighboring gene hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit Neighboring gene microRNA 1960 Neighboring gene adhesion G protein-coupled receptor F3 Neighboring gene selenoprotein I Neighboring gene 40S ribosomal protein S25 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3-hydroxyacyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    acetyl-CoA C-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acetyl-CoA C-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetyl-CoA C-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetyl-CoA C-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enoyl-CoA hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enoyl-CoA hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    long-chain-3-hydroxyacyl-CoA dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-chain-3-hydroxyacyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain-enoyl-CoA hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    long-chain-enoyl-CoA hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial fatty acid beta-oxidation multienzyme complex IC
    Inferred by Curator
    more info
    PubMed 
    mitochondrial fatty acid beta-oxidation multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial inner membrane HDA PubMed 
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    trifunctional enzyme subunit beta, mitochondrial
    Names
    hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta aubunit
    NP_001276727.1
    NP_001276728.1
    NP_663533.1
    XP_017176317.1
    XP_017176318.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289798.1NP_001276727.1  trifunctional enzyme subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001276727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK033462, AK083767, BE945269, BY337615
      Consensus CDS
      CCDS39045.1
      UniProtKB/Swiss-Prot
      Q99JY0
      Related
      ENSMUSP00000110431.1, ENSMUST00000114783.5
      Conserved Domains (2) summary
      cd00751
      Location:56472
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
      TIGR01930
      Location:57471
      AcCoA-C-Actrans; acetyl-CoA acetyltransferases
    2. NM_001289799.1NP_001276728.1  trifunctional enzyme subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001276728.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK150889, BE945269, BY337615, BY778233
      Consensus CDS
      CCDS39045.1
      UniProtKB/Swiss-Prot
      Q99JY0
      Related
      ENSMUSP00000110434.1, ENSMUST00000114786.7
      Conserved Domains (2) summary
      cd00751
      Location:56472
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
      TIGR01930
      Location:57471
      AcCoA-C-Actrans; acetyl-CoA acetyltransferases
    3. NM_145558.2NP_663533.1  trifunctional enzyme subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_663533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK150889, BE945269, BY337615
      Consensus CDS
      CCDS39045.1
      UniProtKB/Swiss-Prot
      Q99JY0
      Related
      ENSMUSP00000026841.8, ENSMUST00000026841.14
      Conserved Domains (2) summary
      cd00751
      Location:56472
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
      TIGR01930
      Location:57471
      AcCoA-C-Actrans; acetyl-CoA acetyltransferases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      30155253..30184593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320828.1XP_017176317.1  trifunctional enzyme subunit beta, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q99JY0
      Conserved Domains (2) summary
      cd00751
      Location:56472
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
      TIGR01930
      Location:57471
      AcCoA-C-Actrans; acetyl-CoA acetyltransferases
    2. XM_017320829.1XP_017176318.1  trifunctional enzyme subunit beta, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q99JY0
      Conserved Domains (2) summary
      cd00751
      Location:56472
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
      TIGR01930
      Location:57471
      AcCoA-C-Actrans; acetyl-CoA acetyltransferases
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