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    Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [ Mus musculus (house mouse) ]

    Gene ID: 231086, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hadhbprovided by MGI
    Official Full Name
    hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit betaprovided by MGI
    Primary source
    MGI:MGI:2136381
    See related
    Ensembl:ENSMUSG00000059447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtp; Mtpb; TP-beta; 4930479F15Rik
    Expression
    Broad expression in heart adult (RPKM 131.2), liver E18 (RPKM 32.5) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Hadhb in Genome Data Viewer
    Location:
    5; 5 B1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30360251..30389591)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30155253..30184593)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (30481862..30511123)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110082J24 gene Neighboring gene GRB2 associated regulator of MAPK1 subtype 2 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene microRNA 1960 Neighboring gene adhesion G protein-coupled receptor F3 Neighboring gene predicted gene, 54326 Neighboring gene selenoprotein I

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetyl-CoA C-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyl-CoA C-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables acetyl-CoA C-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyl-CoA C-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    trifunctional enzyme subunit beta, mitochondrial
    Names
    hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta aubunit
    hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
    NP_001276727.1
    NP_001276728.1
    NP_663533.1
    XP_017176318.1
    XP_036020906.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289798.1NP_001276727.1  trifunctional enzyme subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001276727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK033462, AK083767, BE945269, BY337615
      Consensus CDS
      CCDS39045.1
      UniProtKB/Swiss-Prot
      Q99JY0
      Related
      ENSMUSP00000110431.2, ENSMUST00000114783.6
      Conserved Domains (1) summary
      cd00751
      Location:56472
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    2. NM_001289799.1NP_001276728.1  trifunctional enzyme subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001276728.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK150889, BE945269, BY337615, BY778233
      Consensus CDS
      CCDS39045.1
      UniProtKB/Swiss-Prot
      Q99JY0
      Related
      ENSMUSP00000110434.2, ENSMUST00000114786.8
      Conserved Domains (1) summary
      cd00751
      Location:56472
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    3. NM_145558.2NP_663533.1  trifunctional enzyme subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_663533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK150889, BE945269, BY337615
      Consensus CDS
      CCDS39045.1
      UniProtKB/Swiss-Prot
      Q99JY0
      Related
      ENSMUSP00000026841.9, ENSMUST00000026841.15
      Conserved Domains (1) summary
      cd00751
      Location:56472
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      30360251..30389591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165013.1XP_036020906.1  trifunctional enzyme subunit beta, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd00751
      Location:56472
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    2. XM_017320829.3XP_017176318.1  trifunctional enzyme subunit beta, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q99JY0
      Conserved Domains (1) summary
      cd00751
      Location:56472
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
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