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    Tmem201 transmembrane protein 201 [ Mus musculus (house mouse) ]

    Gene ID: 230917, updated on 23-Nov-2023

    Summary

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    Official Symbol
    Tmem201provided by MGI
    Official Full Name
    transmembrane protein 201provided by MGI
    Primary source
    MGI:MGI:1196277
    See related
    Ensembl:ENSMUSG00000044700 AllianceGenome:MGI:1196277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Net5; Samp1; D4Ertd429e
    Summary
    Enables actin filament binding activity and lamin binding activity. Acts upstream of or within fibroblast migration and nuclear migration. Located in nuclear membrane. Orthologous to human TMEM201 (transmembrane protein 201). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 31.0), adrenal adult (RPKM 24.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem201 in Genome Data Viewer
    Location:
    4 E2; 4 80.15 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_04 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149799832..149822552, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149715375..149738072, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene calsyntenin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149032165-149032348 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene microRNA 7023 Neighboring gene solute carrier family 25, member 33 Neighboring gene predicted gene 13073

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice. Shimizu A, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28893537
    2. A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis. Menghini P, et al. PLoS One, 2017. PMID 28301579, Free PMC Article
    3. [Morphological changes of neurons and neuroglial cells in the brain of senescence-accelerated prone 1 (SAMP1) mice]. Khudoerkov RM, et al. Arkh Patol, 2014 Mar-Apr. PMID 25051721
    4. Impaired motor function in senescence-accelerated mouse prone 1 (SAMP1). Aoyama Y, et al. Brain Res, 2013 Jun 17. PMID 23583482
    5. Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness. Fan J, et al. Metabolism, 2022 Sep. PMID 35792174, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.
      Title: Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.
    2. Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.
      Title: Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.
    3. These observations suggest that tumor suppression was caused not by mtDNA with polymorphic mutations or infection of cytozoic bacteria but by hypothetical heritable cytoplasmic elements other than mtDNA from SAMP1 mice.
      Title: Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice.
    4. data demonstrate a heightened susceptibility to colonic inflammation and tumorigenesis in AOM/DSS-treated SAMP mice with CD-like ileitis
      Title: A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis.
    5. In the SAMP1 mice versus the SAMR1 ones, the glial index rose by 36% in layer III and by 24% in layer V. During simulation of physiological aging, the sizes of neuronal bodies were shown to be virtually unchanged in the cerebral cortex
      Title: [Morphological changes of neurons and neuroglial cells in the brain of senescence-accelerated prone 1 (SAMP1) mice].
    6. At 2- and 4-months old, SAMP1 mice show motor-coordination dysfunction.
      Title: Impaired motor function in senescence-accelerated mouse prone 1 (SAMP1).
    7. findings show that the nuclear envelope protein Samp1 is involved in nuclear movement during fibroblast polarization and migration
      Title: Samp1 is a component of TAN lines and is required for nuclear movement.
    8. Nuclear envelope protein Samp1 (NET5) is involved in nuclear movement during fibroblast polarization and migration. Samp1 is part of the TAN lines complex that contain nesprin-2G and SUN2. Samp1 associates with SUN2 and lamin A/C.
      Title: Samp1 is a component of TAN lines and is required for nuclear movement.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • RP23-383I7.1

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lamin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with cortical endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 201
    Names
    spindle-associated membrane protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284270.1 → NP_001271199.1  transmembrane protein 201 isoform c

      See identical proteins and their annotated locations for NP_001271199.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AK078532, AK086543, AL626808, BE987169, CA316211, CD353644, CD354653, CJ081115, CX562279
      Consensus CDS
      CCDS71523.1
      UniProtKB/Swiss-Prot
      A2A8U2, Q3U5F3, Q6GQS9, Q8BNY3
      Related
      ENSMUSP00000101312.3, ENSMUST00000105687.9
      Conserved Domains (2) summary
      pfam09779
      Location:47 → 169
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:192 → 379
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    2. NM_001284273.1 → NP_001271202.1  transmembrane protein 201 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate 5' and 3' exon structure and initiates translation at a downstream start codon, compared to variant 3. It encodes isoform d, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AK040555, AK079157, AK159041, AL626808
      UniProtKB/TrEMBL
      Q3TXY3
      Conserved Domains (2) summary
      pfam09779
      Location:3 → 125
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:148 → 343
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    3. NM_177672.4 → NP_808340.2  transmembrane protein 201 isoform b

      See identical proteins and their annotated locations for NP_808340.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' exon structure and lacks several exons in the 3' coding region, compared to variant 3. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AK153631, AL626808, CJ081115
      Consensus CDS
      CCDS18965.1
      UniProtKB/TrEMBL
      Q8C397
      Related
      ENSMUSP00000099497.2, ENSMUST00000103208.2
      Conserved Domains (2) summary
      pfam09779
      Location:47 → 169
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:192 → 387
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      149799832..149822552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538820.5 → XP_006538883.1  transmembrane protein 201 isoform X1

      Conserved Domains (2) summary
      pfam09779
      Location:47 → 169
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:192 → 379
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    2. XM_006538822.3 → XP_006538885.1  transmembrane protein 201 isoform X3

      Conserved Domains (2) summary
      pfam09779
      Location:2 → 79
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:102 → 289
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    3. XM_006538821.4 → XP_006538884.1  transmembrane protein 201 isoform X2

      Conserved Domains (2) summary
      pfam09779
      Location:3 → 125
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:148 → 335
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    4. XM_006538823.5 → XP_006538886.1  transmembrane protein 201 isoform X4

      Conserved Domains (2) summary
      pfam09779
      Location:47 → 169
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:192 → 379
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    RNA

    1. XR_003954938.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025106.1: Suppressed sequence

      Description
      NM_001025106.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A8U2.1 GenPept UniProtKB/Swiss-Prot:A2A8U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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