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    Wdtc1 WD and tetratricopeptide repeats 1 [ Mus musculus (house mouse) ]

    Gene ID: 230796, updated on 8-May-2024

    Summary

    Official Symbol
    Wdtc1provided by MGI
    Official Full Name
    WD and tetratricopeptide repeats 1provided by MGI
    Primary source
    MGI:MGI:2685541
    See related
    Ensembl:ENSMUSG00000037622 AllianceGenome:MGI:2685541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    adp; Gm695; adipose
    Summary
    Enables enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Acts upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of cellular biosynthetic process. Located in cytosol and nucleus. Is expressed in heart left ventricle; heart right ventricle; left lung; pancreas; and right lung. Orthologous to human WDTC1 (WD and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 115.3), duodenum adult (RPKM 49.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Wdtc1 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.25 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133019777..133080811, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133292466..133353469, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 1 Neighboring gene STARR-seq mESC enhancer starr_11620 Neighboring gene transmembrane protein 222 Neighboring gene STARR-seq mESC enhancer starr_11622 Neighboring gene STARR-positive B cell enhancer mm9_chr4:132865900-132866201 Neighboring gene STARR-positive B cell enhancer ABC_E7995 Neighboring gene STARR-seq mESC enhancer starr_11626 Neighboring gene STARR-seq mESC enhancer starr_11627 Neighboring gene STARR-positive B cell enhancer ABC_E1657 Neighboring gene STARR-seq mESC enhancer starr_11628 Neighboring gene microRNA 5122 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 1 Neighboring gene RIKEN cDNA 1700091J24 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD and tetratricopeptide repeats protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416526.1NP_001403455.1  WD and tetratricopeptide repeats protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL671882
      UniProtKB/Swiss-Prot
      Q80ZK9
    2. NM_001416528.1NP_001403457.1  WD and tetratricopeptide repeats protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL671882
      UniProtKB/Swiss-Prot
      Q80ZK9
    3. NM_001416529.1NP_001403458.1  WD and tetratricopeptide repeats protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671882
    4. NM_001416531.1NP_001403460.1  WD and tetratricopeptide repeats protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671882
    5. NM_001416532.1NP_001403461.1  WD and tetratricopeptide repeats protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL671882
    6. NM_001416533.1NP_001403462.1  WD and tetratricopeptide repeats protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL671882
    7. NM_001416534.1NP_001403463.1  WD and tetratricopeptide repeats protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL671882
    8. NM_199306.4NP_955010.1  WD and tetratricopeptide repeats protein 1 isoform 1

      See identical proteins and their annotated locations for NP_955010.1

      Status: VALIDATED

      Source sequence(s)
      AL671882
      Consensus CDS
      CCDS18746.1
      UniProtKB/Swiss-Prot
      Q80ZK9
      UniProtKB/TrEMBL
      A2AE98
      Related
      ENSMUSP00000040647.8, ENSMUST00000043305.14
      Conserved Domains (4) summary
      PLN03088
      Location:367437
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:365389
      TPR; TPR repeat [structural motif]
      sd00039
      Location:5188
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:34163
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_184161.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671882
    2. NR_184162.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671882

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133019777..133080811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)