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    Pabpc4 poly(A) binding protein, cytoplasmic 4 [ Mus musculus (house mouse) ]

    Gene ID: 230721, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pabpc4provided by MGI
    Official Full Name
    poly(A) binding protein, cytoplasmic 4provided by MGI
    Primary source
    MGI:MGI:2385206
    See related
    Ensembl:ENSMUSG00000011257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in liver E14 (RPKM 71.8), liver E14.5 (RPKM 71.3) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pabpc4 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123172722..123192718)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123282303..123298925)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (122960154..122976075)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 50623 Neighboring gene predicted gene 12900 Neighboring gene predicted gene, 25788 Neighboring gene predicted gene, 22154 Neighboring gene bone morphogenetic protein 8a Neighboring gene 3-oxoacid CoA transferase 2A Neighboring gene microtubule-actin crosslinking factor 1 Neighboring gene RIKEN cDNA D830031N03 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6685, MGC11665

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables poly(C) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within myeloid cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polyadenylate-binding protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356377.1NP_001343306.1  polyadenylate-binding protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606917, BC056432
      Conserved Domains (1) summary
      TIGR01628
      Location:11611
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    2. NM_130881.3NP_570951.2  polyadenylate-binding protein 4 isoform 1

      See identical proteins and their annotated locations for NP_570951.2

      Status: VALIDATED

      Source sequence(s)
      AL606917, BC056432
      Consensus CDS
      CCDS18614.1
      UniProtKB/TrEMBL
      Q6PHQ9
      Related
      ENSMUSP00000079070.7, ENSMUST00000080178.13
      Conserved Domains (6) summary
      TIGR01628
      Location:11640
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:1291
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97172
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:572639
      PABP; Poly-adenylate binding protein, unique domain
    3. NM_148917.3NP_683717.1  polyadenylate-binding protein 4 isoform 2

      See identical proteins and their annotated locations for NP_683717.1

      Status: VALIDATED

      Source sequence(s)
      AL606917, BC056432
      Consensus CDS
      CCDS18615.1
      UniProtKB/TrEMBL
      Q91YZ8
      Related
      ENSMUSP00000077794.6, ENSMUST00000078734.12
      Conserved Domains (6) summary
      TIGR01628
      Location:11595
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:1291
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97172
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:527594
      PABP; Poly-adenylate binding protein, unique domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      123172722..123192718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503023.4XP_006503086.1  polyadenylate-binding protein 4 isoform X6

      Conserved Domains (1) summary
      TIGR01628
      Location:1418
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    2. XM_030253447.2XP_030109307.1  polyadenylate-binding protein 4 isoform X9

      Conserved Domains (1) summary
      TIGR01628
      Location:1389
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    3. XM_006503024.4XP_006503087.1  polyadenylate-binding protein 4 isoform X7

      Conserved Domains (1) summary
      TIGR01628
      Location:1402
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    4. XM_036164042.1XP_036019935.1  polyadenylate-binding protein 4 isoform X10

      Conserved Domains (1) summary
      TIGR01628
      Location:1373
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    5. XM_006503020.4XP_006503083.1  polyadenylate-binding protein 4 isoform X1

      Conserved Domains (1) summary
      TIGR01628
      Location:11640
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    6. XM_006503022.4XP_006503085.1  polyadenylate-binding protein 4 isoform X4

      UniProtKB/TrEMBL
      A3KFU5
      Related
      ENSMUSP00000101850.2, ENSMUST00000106243.8
      Conserved Domains (1) summary
      TIGR01628
      Location:11611
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    7. XM_006503021.4XP_006503084.1  polyadenylate-binding protein 4 isoform X2

      UniProtKB/TrEMBL
      A3KFU8
      Related
      ENSMUSP00000101848.2, ENSMUST00000106241.8
      Conserved Domains (1) summary
      TIGR01628
      Location:11624
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    8. XM_030253445.2XP_030109305.1  polyadenylate-binding protein 4 isoform X5

      Conserved Domains (1) summary
      TIGR01628
      Location:11595
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    9. XM_036164041.1XP_036019934.1  polyadenylate-binding protein 4 isoform X8

      Conserved Domains (1) summary
      TIGR01628
      Location:1402
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    10. XM_030253444.2XP_030109304.1  polyadenylate-binding protein 4 isoform X3

      Conserved Domains (1) summary
      TIGR01628
      Location:11624
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
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