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    Ipo13 importin 13 [ Mus musculus (house mouse) ]

    Gene ID: 230673, updated on 10-Oct-2024

    Summary

    Official Symbol
    Ipo13provided by MGI
    Official Full Name
    importin 13provided by MGI
    Primary source
    MGI:MGI:2385205
    See related
    Ensembl:ENSMUSG00000033365 AllianceGenome:MGI:2385205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Imp13; Kap13; Ranbp13
    Summary
    Predicted to enable glucocorticoid receptor binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; olfactory epithelium; skin; submandibular gland primordium; and thymus primordium. Orthologous to human IPO13 (importin 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 70.7), ovary adult (RPKM 30.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ipo13 in Genome Data Viewer
    Location:
    4 D1; 4 53.76 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117751689..117772419, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117893268..117915222, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4652 Neighboring gene predicted gene 12841 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit B Neighboring gene STARR-positive B cell enhancer ABC_E10251 Neighboring gene DPH2 homolog Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 3 Neighboring gene artemin Neighboring gene RIKEN cDNA 9530034E10 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC18698

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419414.1NP_001406343.1  importin-13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627128
    2. NM_146152.3NP_666264.1  importin-13 isoform 1

      See identical proteins and their annotated locations for NP_666264.1

      Status: VALIDATED

      Source sequence(s)
      AK052257
      Consensus CDS
      CCDS18542.1
      UniProtKB/Swiss-Prot
      Q6ZQ60, Q8K0C1
      UniProtKB/TrEMBL
      Q3UDQ3
      Related
      ENSMUSP00000035989.6, ENSMUST00000036156.6
      Conserved Domains (3) summary
      smart00913
      Location:45109
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:20650
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:116263
      Xpo1; Exportin 1-like protein

    RNA

    1. NR_185081.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627128

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      117751689..117772419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320147.3XP_017175636.1  importin-13 isoform X1

      Conserved Domains (5) summary
      smart00913
      Location:45109
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:20650
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:116263
      Xpo1; Exportin 1-like protein
      pfam18773
      Location:402441
      Importin_rep; Importin 13 repeat
      pfam18786
      Location:631672
      Importin_rep_2; Importin 13 repeat

    RNA

    1. XR_003954914.2 RNA Sequence