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    Tesk2 testis-specific kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 230661, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tesk2provided by MGI
    Official Full Name
    testis-specific kinase 2provided by MGI
    Primary source
    MGI:MGI:2385204
    See related
    Ensembl:ENSMUSG00000033985 AllianceGenome:MGI:2385204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in actin cytoskeleton organization; focal adhesion assembly; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human TESK2 (testis associated actin remodelling kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 12.8), large intestine adult (RPKM 7.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tesk2 in Genome Data Viewer
    Location:
    4 D1; 4 53.3 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116578107..116661450)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116720909..116804248)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AV051173 Neighboring gene peroxiredoxin 1 Neighboring gene STARR-positive B cell enhancer ABC_E9593 Neighboring gene STARR-positive B cell enhancer ABC_E2706 Neighboring gene methylmalonic aciduria cblC type, with homocystinuria Neighboring gene coiled-coil domain containing 163 Neighboring gene STARR-positive B cell enhancer ABC_E37 Neighboring gene STARR-seq mESC enhancer starr_11147 Neighboring gene STARR-seq mESC enhancer starr_11148 Neighboring gene STARR-seq mESC enhancer starr_11149 Neighboring gene STARR-positive B cell enhancers ABC_E11715 and ABC_E10249 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116480418-116480527 Neighboring gene target of EGR1, member 1 (nuclear) Neighboring gene mutY DNA glycosylase Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Fang Q, et al. Sci Rep, 2019 Mar 4. PMID 30833597, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29168

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity testis-specific protein kinase 2
    Names
    testicular protein kinase 2
    NP_666263.3
    XP_006503071.1
    XP_030109303.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146151.4 → NP_666263.3  dual specificity testis-specific protein kinase 2

      See identical proteins and their annotated locations for NP_666263.3

      Status: VALIDATED

      Source sequence(s)
      AK047755, AL683847
      Consensus CDS
      CCDS18516.1
      UniProtKB/Swiss-Prot
      Q8VCT9
      UniProtKB/TrEMBL
      Q8C0B6
      Related
      ENSMUSP00000041009.7, ENSMUST00000045542.13
      Conserved Domains (2) summary
      smart00219
      Location:62 → 309
      TyrKc; Tyrosine kinase, catalytic domain
      cd14155
      Location:64 → 316
      PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116578107..116661450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253443.2 → XP_030109303.1  dual specificity testis-specific protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      Q8C0B6
      Conserved Domains (1) summary
      cd14155
      Location:144 → 396
      PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

    2. XM_006503008.5 → XP_006503071.1  dual specificity testis-specific protein kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 200
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCT9.1 GenPept UniProtKB/Swiss-Prot:Q8VCT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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