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    NCOA6 nuclear receptor coactivator 6 [ Homo sapiens (human) ]

    Gene ID: 23054, updated on 6-Jun-2024

    Summary

    Official Symbol
    NCOA6provided by HGNC
    Official Full Name
    nuclear receptor coactivator 6provided by HGNC
    Primary source
    HGNC:HGNC:15936
    See related
    Ensembl:ENSG00000198646 MIM:605299; AllianceGenome:HGNC:15936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRC; AIB3; ASC2; PRIP; TRBP; RAP250
    Summary
    The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in testis (RPKM 8.8), thyroid (RPKM 7.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NCOA6 in Genome Data Viewer
    Location:
    20q11.22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (34714774..34825651, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (36435437..36546294, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33302578..33413454, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12843 Neighboring gene Sharpr-MPRA regulatory region 13945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12846 Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33384717-33385693 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33385694-33386669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12848 Neighboring gene high mobility group box 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33450836-33451387 Neighboring gene gamma-glutamyltransferase 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12849

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nuclear receptor coactivator 6 (NCOA6) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0181

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear estrogen receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor coactivator activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear retinoid X receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables nuclear thyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear receptor coactivator 6
    Names
    NRC RAP250
    PPAR-interacting protein
    activating signal cointegrator-2
    amplified in breast cancer protein 3
    amplified in breast cancer-3 protein
    cancer-amplified transcriptional coactivator ASC-2
    nuclear receptor coactivator RAP250
    nuclear receptor-activating protein, 250 kDa
    peroxisome proliferator-activated receptor interacting protein
    thyroid hormone receptor binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242539.2NP_001229468.1  nuclear receptor coactivator 6 isoform 2

      See identical proteins and their annotated locations for NP_001229468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon in the central coding region, compared to variant 3. The encoded isoform (2, also known as NCOA6-beta) is shorter than isoform 1.
      Source sequence(s)
      AF208227, AI498955, AL109824, BC069829, JF707637
      Consensus CDS
      CCDS74720.1
      UniProtKB/TrEMBL
      F6M2K2, F6M2K4
      Conserved Domains (2) summary
      pfam09606
      Location:392803
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:48190
      Nucleic_acid_bd; Putative nucleic acid-binding region
    2. NM_001318240.1NP_001305169.1  nuclear receptor coactivator 6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1, also known as NCOA6-alpha). Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AF208227, AL049709, AL109824
      Consensus CDS
      CCDS13241.1
      UniProtKB/Swiss-Prot
      A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86
      Related
      ENSP00000363929.2, ENST00000374796.6
      Conserved Domains (2) summary
      pfam09606
      Location:392803
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:48190
      Nucleic_acid_bd; Putative nucleic acid-binding region
    3. NM_014071.5NP_054790.2  nuclear receptor coactivator 6 isoform 1

      See identical proteins and their annotated locations for NP_054790.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 encode the same isoform (1, also known as NCOA6-alpha).
      Source sequence(s)
      AI498955, AL049709, AL109824, BC069829, CR749037
      Consensus CDS
      CCDS13241.1
      UniProtKB/Swiss-Prot
      A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86
      Related
      ENSP00000351894.2, ENST00000359003.7
      Conserved Domains (2) summary
      pfam09606
      Location:392803
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:48190
      Nucleic_acid_bd; Putative nucleic acid-binding region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      34714774..34825651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440068.1XP_047296024.1  nuclear receptor coactivator 6 isoform X33

      UniProtKB/TrEMBL
      F6M2K4
    2. XM_047440055.1XP_047296011.1  nuclear receptor coactivator 6 isoform X15

    3. XM_017027744.3XP_016883233.1  nuclear receptor coactivator 6 isoform X13

    4. XM_047440067.1XP_047296023.1  nuclear receptor coactivator 6 isoform X32

      UniProtKB/TrEMBL
      F6M2K4
    5. XM_047440059.1XP_047296015.1  nuclear receptor coactivator 6 isoform X19

    6. XM_047440054.1XP_047296010.1  nuclear receptor coactivator 6 isoform X14

    7. XM_047440052.1XP_047296008.1  nuclear receptor coactivator 6 isoform X12

    8. XM_047440064.1XP_047296020.1  nuclear receptor coactivator 6 isoform X29

      UniProtKB/TrEMBL
      F6M2K4
      Related
      ENSP00000481935.1, ENST00000616167.1
    9. XM_017027751.2XP_016883240.1  nuclear receptor coactivator 6 isoform X28

      UniProtKB/TrEMBL
      F6M2K2, F6M2K4
      Related
      ENSP00000481177.1, ENST00000612493.4
      Conserved Domains (2) summary
      pfam09606
      Location:392803
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:48190
      Nucleic_acid_bd; Putative nucleic acid-binding region
    10. XM_047440057.1XP_047296013.1  nuclear receptor coactivator 6 isoform X17

    11. XM_047440050.1XP_047296006.1  nuclear receptor coactivator 6 isoform X7

    12. XM_017027742.3XP_016883231.1  nuclear receptor coactivator 6 isoform X3

    13. XM_047440066.1XP_047296022.1  nuclear receptor coactivator 6 isoform X31

      UniProtKB/TrEMBL
      F6M2K4
    14. XM_011528727.4XP_011527029.1  nuclear receptor coactivator 6 isoform X10

      Conserved Domains (2) summary
      pfam09606
      Location:427855
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:48195
      Nucleic_acid_bd; Putative nucleic acid-binding region
    15. XM_047440065.1XP_047296021.1  nuclear receptor coactivator 6 isoform X30

      UniProtKB/TrEMBL
      F6M2K4
    16. XM_047440058.1XP_047296014.1  nuclear receptor coactivator 6 isoform X18

    17. XM_047440051.1XP_047296007.1  nuclear receptor coactivator 6 isoform X11

    18. XM_011528726.4XP_011527028.1  nuclear receptor coactivator 6 isoform X9

      Conserved Domains (2) summary
      pfam09606
      Location:427856
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:48195
      Nucleic_acid_bd; Putative nucleic acid-binding region
    19. XM_047440063.1XP_047296019.1  nuclear receptor coactivator 6 isoform X27

      UniProtKB/TrEMBL
      F6M2K4
    20. XM_047440056.1XP_047296012.1  nuclear receptor coactivator 6 isoform X16

    21. XM_047440048.1XP_047296004.1  nuclear receptor coactivator 6 isoform X5

    22. XM_011528721.4XP_011527023.1  nuclear receptor coactivator 6 isoform X4

      See identical proteins and their annotated locations for XP_011527023.1

      Conserved Domains (2) summary
      pfam09606
      Location:427867
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:48195
      Nucleic_acid_bd; Putative nucleic acid-binding region
    23. XM_047440061.1XP_047296017.1  nuclear receptor coactivator 6 isoform X25

      UniProtKB/TrEMBL
      F6M2K4
    24. XM_017027750.3XP_016883239.1  nuclear receptor coactivator 6 isoform X24

      UniProtKB/TrEMBL
      F6M2K4
    25. XM_017027748.2XP_016883237.1  nuclear receptor coactivator 6 isoform X23

    26. XM_017027743.3XP_016883232.1  nuclear receptor coactivator 6 isoform X8

    27. XM_017027741.2XP_016883230.1  nuclear receptor coactivator 6 isoform X2

    28. XM_017027739.2XP_016883228.1  nuclear receptor coactivator 6 isoform X1

    29. XM_047440053.1XP_047296009.1  nuclear receptor coactivator 6 isoform X13

    30. XM_047440049.1XP_047296005.1  nuclear receptor coactivator 6 isoform X6

      UniProtKB/Swiss-Prot
      A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86
    31. XM_047440047.1XP_047296003.1  nuclear receptor coactivator 6 isoform X1

    32. XM_047440062.1XP_047296018.1  nuclear receptor coactivator 6 isoform X26

    33. XM_047440060.1XP_047296016.1  nuclear receptor coactivator 6 isoform X22

    34. XM_006723755.4XP_006723818.1  nuclear receptor coactivator 6 isoform X21

      See identical proteins and their annotated locations for XP_006723818.1

      UniProtKB/TrEMBL
      F6M2K3
      Conserved Domains (2) summary
      pfam09606
      Location:392803
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:48190
      Nucleic_acid_bd; Putative nucleic acid-binding region
    35. XM_017027746.2XP_016883235.1  nuclear receptor coactivator 6 isoform X20

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      36435437..36546294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323279.1XP_054179254.1  nuclear receptor coactivator 6 isoform X33

      UniProtKB/TrEMBL
      F6M2K4
    2. XM_054323261.1XP_054179236.1  nuclear receptor coactivator 6 isoform X15

    3. XM_054323258.1XP_054179233.1  nuclear receptor coactivator 6 isoform X13

    4. XM_054323278.1XP_054179253.1  nuclear receptor coactivator 6 isoform X32

      UniProtKB/TrEMBL
      F6M2K4
    5. XM_054323265.1XP_054179240.1  nuclear receptor coactivator 6 isoform X19

    6. XM_054323260.1XP_054179235.1  nuclear receptor coactivator 6 isoform X14

    7. XM_054323257.1XP_054179232.1  nuclear receptor coactivator 6 isoform X12

    8. XM_054323275.1XP_054179250.1  nuclear receptor coactivator 6 isoform X29

      UniProtKB/TrEMBL
      F6M2K4
    9. XM_054323274.1XP_054179249.1  nuclear receptor coactivator 6 isoform X28

      UniProtKB/TrEMBL
      F6M2K2, F6M2K4
    10. XM_054323263.1XP_054179238.1  nuclear receptor coactivator 6 isoform X17

    11. XM_054323252.1XP_054179227.1  nuclear receptor coactivator 6 isoform X7

    12. XM_054323248.1XP_054179223.1  nuclear receptor coactivator 6 isoform X3

    13. XM_054323277.1XP_054179252.1  nuclear receptor coactivator 6 isoform X31

      UniProtKB/TrEMBL
      F6M2K4
    14. XM_054323255.1XP_054179230.1  nuclear receptor coactivator 6 isoform X10

    15. XM_054323276.1XP_054179251.1  nuclear receptor coactivator 6 isoform X30

      UniProtKB/TrEMBL
      F6M2K4
    16. XM_054323264.1XP_054179239.1  nuclear receptor coactivator 6 isoform X18

    17. XM_054323256.1XP_054179231.1  nuclear receptor coactivator 6 isoform X11

    18. XM_054323254.1XP_054179229.1  nuclear receptor coactivator 6 isoform X9

    19. XM_054323273.1XP_054179248.1  nuclear receptor coactivator 6 isoform X27

      UniProtKB/TrEMBL
      F6M2K4
    20. XM_054323262.1XP_054179237.1  nuclear receptor coactivator 6 isoform X16

    21. XM_054323250.1XP_054179225.1  nuclear receptor coactivator 6 isoform X5

    22. XM_054323249.1XP_054179224.1  nuclear receptor coactivator 6 isoform X4

    23. XM_054323271.1XP_054179246.1  nuclear receptor coactivator 6 isoform X25

      UniProtKB/TrEMBL
      F6M2K4
    24. XM_054323270.1XP_054179245.1  nuclear receptor coactivator 6 isoform X24

      UniProtKB/TrEMBL
      F6M2K4
    25. XM_054323269.1XP_054179244.1  nuclear receptor coactivator 6 isoform X23

    26. XM_054323253.1XP_054179228.1  nuclear receptor coactivator 6 isoform X8

    27. XM_054323247.1XP_054179222.1  nuclear receptor coactivator 6 isoform X2

    28. XM_054323245.1XP_054179220.1  nuclear receptor coactivator 6 isoform X1

    29. XM_054323259.1XP_054179234.1  nuclear receptor coactivator 6 isoform X13

    30. XM_054323251.1XP_054179226.1  nuclear receptor coactivator 6 isoform X6

      UniProtKB/Swiss-Prot
      A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86
    31. XM_054323246.1XP_054179221.1  nuclear receptor coactivator 6 isoform X1

    32. XM_054323272.1XP_054179247.1  nuclear receptor coactivator 6 isoform X26

    33. XM_054323268.1XP_054179243.1  nuclear receptor coactivator 6 isoform X22

    34. XM_054323267.1XP_054179242.1  nuclear receptor coactivator 6 isoform X21

      UniProtKB/TrEMBL
      F6M2K3
    35. XM_054323266.1XP_054179241.1  nuclear receptor coactivator 6 isoform X20