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    ZSWIM8 zinc finger SWIM-type containing 8 [ Homo sapiens (human) ]

    Gene ID: 23053, updated on 5-May-2024

    Summary

    Official Symbol
    ZSWIM8provided by HGNC
    Official Full Name
    zinc finger SWIM-type containing 8provided by HGNC
    Primary source
    HGNC:HGNC:23528
    See related
    Ensembl:ENSG00000214655 MIM:619213; AllianceGenome:HGNC:23528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA0913
    Summary
    Enables ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 21.6), spleen (RPKM 16.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZSWIM8 in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73785606..73801793)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74657006..74673193)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75545364..75561551)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3575 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75543706-75543880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2488 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75548316-75549515 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene NDST2-ZSWIM8-AS1 readthrough Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2489 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2490 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75574449-75574702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579102-75579602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579603-75580103 Neighboring gene calcium/calmodulin dependent protein kinase II gamma Neighboring gene MPRA-validated peak1013 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75617818-75618318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75618319-75618819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2493

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ34302, KIAA0913, MGC168869, MGC168870, 4832404P21Rik

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc finger SWIM domain-containing protein 8
    Names
    Dorado
    Pelado

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242487.2NP_001229416.1  zinc finger SWIM domain-containing protein 8 isoform 2

      See identical proteins and their annotated locations for NP_001229416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AB020720, AC022400, BC040726, BC151206
      Consensus CDS
      CCDS60560.1
      UniProtKB/Swiss-Prot
      A7E2V4, B2RP37, O94987, Q17RS8, Q2TAB8, Q6P439, Q8IW81, Q8NB34, Q9H8F3
      UniProtKB/TrEMBL
      S4R393
      Related
      ENSP00000474748.1, ENST00000605216.5
      Conserved Domains (1) summary
      cl19527
      Location:131263
      SWIM; SWIM zinc finger
    2. NM_001242488.2NP_001229417.1  zinc finger SWIM domain-containing protein 8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites in the 3' coding region with the latter resulting in a frameshift, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB020720, AC022400, BC040726, BC111006, BC151206
      UniProtKB/TrEMBL
      S4R393
      Conserved Domains (1) summary
      cl19527
      Location:131263
      SWIM; SWIM zinc finger
    3. NM_001367799.1NP_001354728.1  zinc finger SWIM domain-containing protein 8 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC022400
      Consensus CDS
      CCDS91266.1
      UniProtKB/TrEMBL
      S4R393, S4R410
      Related
      ENSP00000474944.1, ENST00000604729.6
    4. NM_015037.4NP_055852.2  zinc finger SWIM domain-containing protein 8 isoform 1

      See identical proteins and their annotated locations for NP_055852.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1).
      Source sequence(s)
      AB020720, AC022400, AK023742, BC040726, BC151206
      Consensus CDS
      CCDS44440.1
      UniProtKB/TrEMBL
      S4R393
      Related
      ENSP00000381693.2, ENST00000398706.6
      Conserved Domains (1) summary
      cl19527
      Location:131263
      SWIM; SWIM zinc finger

    RNA

    1. NR_160292.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC022400

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      73785606..73801793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269648.3XP_005269705.1  zinc finger SWIM domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      S4R393
      Conserved Domains (1) summary
      cl19527
      Location:131263
      SWIM; SWIM zinc finger
    2. XM_017015978.2XP_016871467.1  zinc finger SWIM domain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      S4R393
    3. XM_006717725.4XP_006717788.1  zinc finger SWIM domain-containing protein 8 isoform X11

      UniProtKB/TrEMBL
      S4R393
      Related
      ENSP00000474043.1, ENST00000603114.5
      Conserved Domains (1) summary
      cl19527
      Location:131263
      SWIM; SWIM zinc finger
    4. XM_047424867.1XP_047280823.1  zinc finger SWIM domain-containing protein 8 isoform X10

    5. XM_047424860.1XP_047280816.1  zinc finger SWIM domain-containing protein 8 isoform X3

    6. XM_047424868.1XP_047280824.1  zinc finger SWIM domain-containing protein 8 isoform X12

    7. XM_047424861.1XP_047280817.1  zinc finger SWIM domain-containing protein 8 isoform X4

    8. XM_047424869.1XP_047280825.1  zinc finger SWIM domain-containing protein 8 isoform X13

    9. XM_047424870.1XP_047280826.1  zinc finger SWIM domain-containing protein 8 isoform X14

    10. XM_047424862.1XP_047280818.1  zinc finger SWIM domain-containing protein 8 isoform X5

    11. XM_005269655.4XP_005269712.1  zinc finger SWIM domain-containing protein 8 isoform X16

      UniProtKB/TrEMBL
      S4R393
      Conserved Domains (1) summary
      cl19527
      Location:131263
      SWIM; SWIM zinc finger
    12. XM_047424865.1XP_047280821.1  zinc finger SWIM domain-containing protein 8 isoform X8

    13. XM_047424871.1XP_047280827.1  zinc finger SWIM domain-containing protein 8 isoform X15

    14. XM_047424863.1XP_047280819.1  zinc finger SWIM domain-containing protein 8 isoform X6

    15. XM_047424872.1XP_047280828.1  zinc finger SWIM domain-containing protein 8 isoform X17

    16. XM_047424866.1XP_047280822.1  zinc finger SWIM domain-containing protein 8 isoform X9

    17. XM_047424864.1XP_047280820.1  zinc finger SWIM domain-containing protein 8 isoform X7

    18. XM_011539544.2XP_011537846.1  zinc finger SWIM domain-containing protein 8 isoform X18

      UniProtKB/TrEMBL
      H7BZ52
      Related
      ENSP00000387828.2, ENST00000433366.6
      Conserved Domains (1) summary
      cl19527
      Location:131263
      SWIM; SWIM zinc finger
    19. XM_047424874.1XP_047280830.1  zinc finger SWIM domain-containing protein 8 isoform X19

    20. XM_047424875.1XP_047280831.1  zinc finger SWIM domain-containing protein 8 isoform X20

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      74657006..74673193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365274.1XP_054221249.1  zinc finger SWIM domain-containing protein 8 isoform X1

    2. XM_054365275.1XP_054221250.1  zinc finger SWIM domain-containing protein 8 isoform X2

    3. XM_054365283.1XP_054221258.1  zinc finger SWIM domain-containing protein 8 isoform X11

    4. XM_054365282.1XP_054221257.1  zinc finger SWIM domain-containing protein 8 isoform X10

    5. XM_054365276.1XP_054221251.1  zinc finger SWIM domain-containing protein 8 isoform X3

    6. XM_054365284.1XP_054221259.1  zinc finger SWIM domain-containing protein 8 isoform X12

    7. XM_054365277.1XP_054221252.1  zinc finger SWIM domain-containing protein 8 isoform X4

    8. XM_054365285.1XP_054221260.1  zinc finger SWIM domain-containing protein 8 isoform X13

    9. XM_054365286.1XP_054221261.1  zinc finger SWIM domain-containing protein 8 isoform X14

    10. XM_054365278.1XP_054221253.1  zinc finger SWIM domain-containing protein 8 isoform X5

    11. XM_054365288.1XP_054221263.1  zinc finger SWIM domain-containing protein 8 isoform X16

    12. XM_054365280.1XP_054221255.1  zinc finger SWIM domain-containing protein 8 isoform X8

    13. XM_054365287.1XP_054221262.1  zinc finger SWIM domain-containing protein 8 isoform X15

    14. XM_054365279.1XP_054221254.1  zinc finger SWIM domain-containing protein 8 isoform X6

    15. XM_054365289.1XP_054221264.1  zinc finger SWIM domain-containing protein 8 isoform X17

    16. XM_054365281.1XP_054221256.1  zinc finger SWIM domain-containing protein 8 isoform X9

    17. XM_054365290.1XP_054221265.1  zinc finger SWIM domain-containing protein 8 isoform X18

    18. XM_054365291.1XP_054221266.1  zinc finger SWIM domain-containing protein 8 isoform X19

    19. XM_054365292.1XP_054221267.1  zinc finger SWIM domain-containing protein 8 isoform X20

    20. XM_054365293.1XP_054221268.1  zinc finger SWIM domain-containing protein 8 isoform X21

    21. XM_054365294.1XP_054221269.1  zinc finger SWIM domain-containing protein 8 isoform X22