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    Leprot leptin receptor overlapping transcript [ Mus musculus (house mouse) ]

    Gene ID: 230514, updated on 27-Nov-2024

    Summary

    Official Symbol
    Leprotprovided by MGI
    Official Full Name
    leptin receptor overlapping transcriptprovided by MGI
    Primary source
    MGI:MGI:2687005
    See related
    Ensembl:ENSMUSG00000035212 AllianceGenome:MGI:2687005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LEPR; VPS55; Endo1`; Obrgrp; OB-RGRP; Endospanin1
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of protein localization to cell surface; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus. Predicted to be active in endosome. Is expressed in central nervous system; heart valve; and retina nuclear layer. Orthologous to human LEPROT (leptin receptor overlapping transcript). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 58.2), lung adult (RPKM 39.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Leprot in Genome Data Viewer
    Location:
    4 C6; 4 46.94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101504922..101516561)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101647783..101659364)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10910 Neighboring gene adenylate kinase 4 Neighboring gene STARR-seq mESC enhancer starr_10915 Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene predicted gene, 36012 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:101319917-101320026 Neighboring gene STARR-positive B cell enhancer ABC_E2698 Neighboring gene STARR-seq mESC enhancer starr_10917 Neighboring gene leptin receptor Neighboring gene STARR-seq mESC enhancer starr_10918 Neighboring gene PRAME like 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    General gene information

    Clone Names

    • MGC6694

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leptin receptor gene-related protein
    Names
    OB-R gene-related protein
    endospanin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419413.1NP_001406342.1  leptin receptor gene-related protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL929373, BX323551
      Related
      ENSMUSP00000102540.2, ENSMUST00000106927.2
    2. NM_175036.5NP_778201.1  leptin receptor gene-related protein isoform 1

      See identical proteins and their annotated locations for NP_778201.1

      Status: VALIDATED

      Source sequence(s)
      AL929373, BX323551
      Consensus CDS
      CCDS18396.1
      UniProtKB/Swiss-Prot
      A2AV64, O89013, Q3TGT4, Q3TWZ2, Q545G9, Q91Z23
      Related
      ENSMUSP00000030254.9, ENSMUST00000030254.15
      Conserved Domains (1) summary
      pfam04133
      Location:7124
      Vps55; Vacuolar protein sorting 55

    RNA

    1. NR_185080.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL929373, BX323551

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      101504922..101516561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)