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    DOP1A DOP1 leucine zipper like protein A [ Homo sapiens (human) ]

    Gene ID: 23033, updated on 17-Jun-2024

    Summary

    Official Symbol
    DOP1Aprovided by HGNC
    Official Full Name
    DOP1 leucine zipper like protein Aprovided by HGNC
    Primary source
    HGNC:HGNC:21194
    See related
    Ensembl:ENSG00000083097 MIM:616823; AllianceGenome:HGNC:21194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOP1; DOPEY1; KIAA1117; dJ202D23.2
    Summary
    Predicted to be involved in Golgi to endosome transport and endoplasmic reticulum organization. Predicted to be located in Golgi membrane. Predicted to be active in endosome and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 7.6), thyroid (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DOP1A in Genome Data Viewer
    Location:
    6q14.1
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (83067671..83171350)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (84290676..84394587)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83777390..83881069)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377877 Neighboring gene MPRA-validated peak5926 silencer Neighboring gene ubiquitin protein ligase E3D Neighboring gene leucine aminopeptidase 3 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:83710771-83710962 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:83747652-83748851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24783 Neighboring gene NANOG hESC enhancer GRCh37_chr6:83821047-83821571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17356 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:83902947-83903446 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene MPRA-validated peak5928 silencer Neighboring gene malic enzyme 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:84004031-84004257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17358

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35610

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi-associated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein dopey-1
    Names
    dopey family member 1
    homolog of yeast DOP1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199942.2NP_001186871.1  protein dopey-1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and has an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is longer compared to isoform a.
      Source sequence(s)
      AL121716, AL139333
      Consensus CDS
      CCDS64467.1
      UniProtKB/TrEMBL
      B2RWN9, F6U2K4, Q5TA12
      Related
      ENSP00000237163.6, ENST00000237163.9
      Conserved Domains (2) summary
      pfam04118
      Location:13295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20822318
      Dopey_N; Dopey, N-terminal
    2. NM_001385856.1NP_001372785.1  protein dopey-1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20812317
      Dopey_N; Dopey, N-terminal
    3. NM_001385857.1NP_001372786.1  protein dopey-1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20812317
      Dopey_N; Dopey, N-terminal
    4. NM_001385858.1NP_001372787.1  protein dopey-1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (1) summary
      cl04407
      Location:1146
      Dopey_N; Dopey, N-terminal
    5. NM_001385859.1NP_001372788.1  protein dopey-1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (1) summary
      cl04407
      Location:18161976
      Dopey_N; Dopey, N-terminal
    6. NM_001385860.1NP_001372789.1  protein dopey-1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20812317
      Dopey_N; Dopey, N-terminal
    7. NM_001385861.1NP_001372790.1  protein dopey-1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20812317
      Dopey_N; Dopey, N-terminal
    8. NM_001385863.1NP_001372792.1  protein dopey-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      Consensus CDS
      CCDS64467.1
      UniProtKB/TrEMBL
      B2RWN9, F6U2K4, Q5TA12
      Conserved Domains (2) summary
      pfam04118
      Location:13295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20822318
      Dopey_N; Dopey, N-terminal
    9. NM_001385864.1NP_001372793.1  protein dopey-1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      Conserved Domains (1) summary
      cl04407
      Location:15791815
      Dopey_N; Dopey, N-terminal
    10. NM_001385865.1NP_001372794.1  protein dopey-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20822318
      Dopey_N; Dopey, N-terminal
    11. NM_015018.4NP_055833.2  protein dopey-1 isoform a

      See identical proteins and their annotated locations for NP_055833.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform a).
      Source sequence(s)
      AL121716, AL139333
      Consensus CDS
      CCDS4996.1
      UniProtKB/Swiss-Prot
      Q5JWR5, Q86XV1, Q9H5J5, Q9NSL4, Q9UPN5, Q9Y414
      UniProtKB/TrEMBL
      B2RWN9
      Related
      ENSP00000195654.3, ENST00000349129.7
      Conserved Domains (2) summary
      pfam04118
      Location:13299
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20912327
      Dopey_N; Dopey, N-terminal

    RNA

    1. NR_169790.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
    2. NR_169791.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      83067671..83171350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010559.2XP_016866048.1  protein dopey-1 isoform X1

      UniProtKB/TrEMBL
      B2RWN9
    2. XM_017010564.2XP_016866053.1  protein dopey-1 isoform X5

      UniProtKB/Swiss-Prot
      Q5JWR5, Q86XV1, Q9H5J5, Q9NSL4, Q9UPN5, Q9Y414
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13299
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20912327
      Dopey_N; Dopey, N-terminal
    3. XM_017010572.2XP_016866061.1  protein dopey-1 isoform X11

      UniProtKB/TrEMBL
      B2RWN9
    4. XM_047418447.1XP_047274403.1  protein dopey-1 isoform X15

      UniProtKB/TrEMBL
      B2RWN9
    5. XM_047418448.1XP_047274404.1  protein dopey-1 isoform X15

      UniProtKB/TrEMBL
      B2RWN9
    6. XM_017010571.2XP_016866060.1  protein dopey-1 isoform X9

      UniProtKB/TrEMBL
      B2RWN9
    7. XM_047418442.1XP_047274398.1  protein dopey-1 isoform X12

      UniProtKB/TrEMBL
      B2RWN9
    8. XM_047418443.1XP_047274399.1  protein dopey-1 isoform X12

      UniProtKB/TrEMBL
      B2RWN9
    9. XM_047418451.1XP_047274407.1  protein dopey-1 isoform X18

      UniProtKB/TrEMBL
      B2RWN9
    10. XM_011535619.3XP_011533921.1  protein dopey-1 isoform X3

      See identical proteins and their annotated locations for XP_011533921.1

      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13299
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20812317
      Dopey_N; Dopey, N-terminal
    11. XM_047418434.1XP_047274390.1  protein dopey-1 isoform X7

      UniProtKB/TrEMBL
      B2RWN9
    12. XM_017010561.2XP_016866050.1  protein dopey-1 isoform X2

      UniProtKB/TrEMBL
      B2RWN9, F6U2K4, Q5TA12
      Conserved Domains (2) summary
      pfam04118
      Location:13295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20822318
      Dopey_N; Dopey, N-terminal
    13. XM_017010570.2XP_016866059.1  protein dopey-1 isoform X8

      UniProtKB/TrEMBL
      B2RWN9
    14. XM_047418440.1XP_047274396.1  protein dopey-1 isoform X10

      UniProtKB/TrEMBL
      B2RWN9
    15. XM_047418445.1XP_047274401.1  protein dopey-1 isoform X13

      UniProtKB/TrEMBL
      B2RWN9
    16. XM_047418450.1XP_047274406.1  protein dopey-1 isoform X17

      UniProtKB/TrEMBL
      B2RWN9
    17. XM_017010560.3XP_016866049.1  protein dopey-1 isoform X1

      UniProtKB/TrEMBL
      B2RWN9
    18. XM_047418430.1XP_047274386.1  protein dopey-1 isoform X3

      UniProtKB/TrEMBL
      B2RWN9
    19. XM_047418435.1XP_047274391.1  protein dopey-1 isoform X7

      UniProtKB/TrEMBL
      B2RWN9
    20. XM_047418449.1XP_047274405.1  protein dopey-1 isoform X16

      UniProtKB/TrEMBL
      B2RWN9
    21. XM_047418446.1XP_047274402.1  protein dopey-1 isoform X14

      UniProtKB/TrEMBL
      B2RWN9
    22. XM_017010562.3XP_016866051.1  protein dopey-1 isoform X2

      UniProtKB/TrEMBL
      B2RWN9, F6U2K4, Q5TA12
      Conserved Domains (2) summary
      pfam04118
      Location:13295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:20822318
      Dopey_N; Dopey, N-terminal
    23. XM_047418433.1XP_047274389.1  protein dopey-1 isoform X6

      UniProtKB/TrEMBL
      B2RWN9
    24. XM_047418432.1XP_047274388.1  protein dopey-1 isoform X4

      UniProtKB/TrEMBL
      B2RWN9
    25. XM_047418438.1XP_047274394.1  protein dopey-1 isoform X8

      UniProtKB/TrEMBL
      B2RWN9
    26. XM_047418439.1XP_047274395.1  protein dopey-1 isoform X10

      UniProtKB/TrEMBL
      B2RWN9
    27. XM_047418444.1XP_047274400.1  protein dopey-1 isoform X13

      UniProtKB/TrEMBL
      B2RWN9
    28. XM_047418452.1XP_047274408.1  protein dopey-1 isoform X19

      UniProtKB/TrEMBL
      B2RWN9
    29. XM_047418453.1XP_047274409.1  protein dopey-1 isoform X20

      UniProtKB/TrEMBL
      B2RWN9
    30. XM_047418455.1XP_047274411.1  protein dopey-1 isoform X24

      UniProtKB/TrEMBL
      B2RWN9
    31. XM_017010573.1XP_016866062.1  protein dopey-1 isoform X21

      UniProtKB/TrEMBL
      B2RWN9
    32. XM_017010574.1XP_016866063.1  protein dopey-1 isoform X22

      UniProtKB/TrEMBL
      B2RWN9
    33. XM_047418454.1XP_047274410.1  protein dopey-1 isoform X23

      UniProtKB/TrEMBL
      B2RWN9
    34. XM_047418428.1XP_047274384.1  protein dopey-1 isoform X1

      UniProtKB/TrEMBL
      B2RWN9
    35. XM_047418431.1XP_047274387.1  protein dopey-1 isoform X3

      UniProtKB/TrEMBL
      B2RWN9
    36. XM_047418436.1XP_047274392.1  protein dopey-1 isoform X7

      UniProtKB/TrEMBL
      B2RWN9
    37. XM_047418441.1XP_047274397.1  protein dopey-1 isoform X10

      UniProtKB/TrEMBL
      B2RWN9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      84290676..84394587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354754.1XP_054210729.1  protein dopey-1 isoform X1

      UniProtKB/TrEMBL
      B2RWN9
    2. XM_054354763.1XP_054210738.1  protein dopey-1 isoform X5

      UniProtKB/TrEMBL
      B2RWN9
    3. XM_054354774.1XP_054210749.1  protein dopey-1 isoform X11

      UniProtKB/TrEMBL
      B2RWN9
    4. XM_054354780.1XP_054210755.1  protein dopey-1 isoform X15

      UniProtKB/TrEMBL
      B2RWN9
    5. XM_054354781.1XP_054210756.1  protein dopey-1 isoform X15

      UniProtKB/TrEMBL
      B2RWN9
    6. XM_054354770.1XP_054210745.1  protein dopey-1 isoform X9

      UniProtKB/TrEMBL
      B2RWN9
    7. XM_054354775.1XP_054210750.1  protein dopey-1 isoform X12

      UniProtKB/TrEMBL
      B2RWN9
    8. XM_054354776.1XP_054210751.1  protein dopey-1 isoform X12

      UniProtKB/TrEMBL
      B2RWN9
    9. XM_054354784.1XP_054210759.1  protein dopey-1 isoform X18

      UniProtKB/TrEMBL
      B2RWN9
    10. XM_054354759.1XP_054210734.1  protein dopey-1 isoform X3

      UniProtKB/TrEMBL
      B2RWN9
    11. XM_054354765.1XP_054210740.1  protein dopey-1 isoform X7

      UniProtKB/TrEMBL
      B2RWN9
    12. XM_054354757.1XP_054210732.1  protein dopey-1 isoform X2

      UniProtKB/TrEMBL
      B2RWN9
    13. XM_054354768.1XP_054210743.1  protein dopey-1 isoform X8

      UniProtKB/TrEMBL
      B2RWN9
    14. XM_054354772.1XP_054210747.1  protein dopey-1 isoform X10

      UniProtKB/TrEMBL
      B2RWN9
    15. XM_054354778.1XP_054210753.1  protein dopey-1 isoform X13

      UniProtKB/TrEMBL
      B2RWN9
    16. XM_054354783.1XP_054210758.1  protein dopey-1 isoform X17

      UniProtKB/TrEMBL
      B2RWN9
    17. XM_054354755.1XP_054210730.1  protein dopey-1 isoform X1

      UniProtKB/TrEMBL
      B2RWN9
    18. XM_054354760.1XP_054210735.1  protein dopey-1 isoform X3

      UniProtKB/TrEMBL
      B2RWN9
    19. XM_054354766.1XP_054210741.1  protein dopey-1 isoform X7

      UniProtKB/TrEMBL
      B2RWN9
    20. XM_054354782.1XP_054210757.1  protein dopey-1 isoform X16

      UniProtKB/TrEMBL
      B2RWN9
    21. XM_054354779.1XP_054210754.1  protein dopey-1 isoform X14

      UniProtKB/TrEMBL
      B2RWN9
    22. XM_054354758.1XP_054210733.1  protein dopey-1 isoform X2

      UniProtKB/TrEMBL
      B2RWN9
    23. XM_054354764.1XP_054210739.1  protein dopey-1 isoform X6

      UniProtKB/TrEMBL
      B2RWN9
    24. XM_054354762.1XP_054210737.1  protein dopey-1 isoform X4

      UniProtKB/TrEMBL
      B2RWN9
    25. XM_054354769.1XP_054210744.1  protein dopey-1 isoform X8

      UniProtKB/TrEMBL
      B2RWN9
    26. XM_054354771.1XP_054210746.1  protein dopey-1 isoform X10

      UniProtKB/TrEMBL
      B2RWN9
    27. XM_054354777.1XP_054210752.1  protein dopey-1 isoform X13

      UniProtKB/TrEMBL
      B2RWN9
    28. XM_054354785.1XP_054210760.1  protein dopey-1 isoform X19

      UniProtKB/TrEMBL
      B2RWN9
    29. XM_054354786.1XP_054210761.1  protein dopey-1 isoform X20

      UniProtKB/TrEMBL
      B2RWN9
    30. XM_054354790.1XP_054210765.1  protein dopey-1 isoform X24

      UniProtKB/TrEMBL
      B2RWN9
    31. XM_054354787.1XP_054210762.1  protein dopey-1 isoform X21

      UniProtKB/TrEMBL
      B2RWN9
    32. XM_054354788.1XP_054210763.1  protein dopey-1 isoform X22

      UniProtKB/TrEMBL
      B2RWN9
    33. XM_054354789.1XP_054210764.1  protein dopey-1 isoform X23

      UniProtKB/TrEMBL
      B2RWN9
    34. XM_054354756.1XP_054210731.1  protein dopey-1 isoform X1

      UniProtKB/TrEMBL
      B2RWN9
    35. XM_054354761.1XP_054210736.1  protein dopey-1 isoform X3

      UniProtKB/TrEMBL
      B2RWN9
    36. XM_054354767.1XP_054210742.1  protein dopey-1 isoform X7

      UniProtKB/TrEMBL
      B2RWN9
    37. XM_054354773.1XP_054210748.1  protein dopey-1 isoform X10

      UniProtKB/TrEMBL
      B2RWN9