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    Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 [ Mus musculus (house mouse) ]

    Gene ID: 230075, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ndufb6provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B6provided by MGI
    Primary source
    MGI:MGI:2684983
    See related
    Ensembl:ENSMUSG00000071014
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm137; CI-B17
    Summary
    This gene encodes a subunit of complex I (NADH:ubiquinone oxidoreductase) of the mitochondrial respiratory chain. This complex functions in electron transport and generation of a proton gradient across the inner mitochondrial membrane to drive ATP synthesis. Data from human cell lines suggests that the encoded subunit may be required for electron transfer activity. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in heart adult (RPKM 89.9), kidney adult (RPKM 75.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ndufb6 in Genome Data Viewer
    Location:
    4; 4 A5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40270591..40279421, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40270591..40279421, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (40217696..40226401, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DEAD/H box helicase 58 Neighboring gene topoisomerase I binding, arginine/serine-rich Neighboring gene small integral membrane protein 27 Neighboring gene RIKEN cDNA 4930509K18 gene Neighboring gene predicted gene, 23338

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mitochondrial respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
    Names
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6
    NADH-ubiquinone oxidoreductase B17 subunit
    complex I-B17
    NP_001028477.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033305.3NP_001028477.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

      See identical proteins and their annotated locations for NP_001028477.1

      Status: REVIEWED

      Source sequence(s)
      AK146762, BY233633, CK794473
      Consensus CDS
      CCDS18045.1
      UniProtKB/Swiss-Prot
      Q3UIU2
      UniProtKB/TrEMBL
      A2AP31
      Related
      ENSMUSP00000092746.4, ENSMUST00000095128.10
      Conserved Domains (1) summary
      pfam09782
      Location:1128
      NDUF_B6; NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      40270591..40279421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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