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    PLCH1 phospholipase C eta 1 [ Homo sapiens (human) ]

    Gene ID: 23007, updated on 5-Mar-2024

    Summary

    Official Symbol
    PLCH1provided by HGNC
    Official Full Name
    phospholipase C eta 1provided by HGNC
    Primary source
    HGNC:HGNC:29185
    See related
    Ensembl:ENSG00000114805 MIM:612835; AllianceGenome:HGNC:29185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPE14; PLCL3; PLC-L3; PLC eta 1
    Summary
    PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
    Expression
    Biased expression in testis (RPKM 4.0), thyroid (RPKM 1.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See PLCH1 in Genome Data Viewer
    Location:
    3q25.31
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (155450934..155745071, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (158220392..158518944, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (155197670..155462860, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:155139477-155140078 Neighboring gene DTWD1 pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 715, pseudogene Neighboring gene PLCH1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14832 Neighboring gene PLCH1 antisense RNA 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:155229919-155230575 Neighboring gene uncharacterized LOC124906297 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:155336094-155336620 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:155336621-155337145 Neighboring gene NANOG hESC enhancer GRCh37_chr3:155337230-155337774 Neighboring gene ribosomal protein L6 pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:155462097-155462718 Neighboring gene ribosomal protein L7a pseudogene 24 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:155507600-155507774 Neighboring gene chromosome 3 open reading frame 33 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:155508647-155509846 Neighboring gene MPRA-validated peak4874 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14833

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Holoprosencephaly 14
    MedGen: C5676994 OMIM: 619895 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
    Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117152, DKFZp434C1372

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphatidylinositol-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
    Names
    PLC-eta-1
    phosphoinositide phospholipase C-eta-1
    phospholipase C-eta1a
    phospholipase C-eta1b
    phospholipase C-like 3
    phospholipase C-like protein 3
    NP_001124432.1
    NP_001124433.1
    NP_001336179.1
    NP_001336180.1
    NP_001336181.1
    NP_055811.2
    XP_005247295.1
    XP_005247296.1
    XP_011510862.1
    XP_011510863.1
    XP_011510864.1
    XP_011510867.1
    XP_011510868.1
    XP_016861412.1
    XP_016861414.1
    XP_016861415.1
    XP_016861416.1
    XP_047303701.1
    XP_047303702.1
    XP_047303703.1
    XP_054201713.1
    XP_054201714.1
    XP_054201715.1
    XP_054201716.1
    XP_054201717.1
    XP_054201718.1
    XP_054201719.1
    XP_054201720.1
    XP_054201721.1
    XP_054201722.1
    XP_054201723.1
    XP_054201724.1
    XP_054201725.1
    XP_054201726.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130960.2NP_001124432.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform a

      See identical proteins and their annotated locations for NP_001124432.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC012022, AC132006, AK096620, AY691171, BC113950, DA206803
      Consensus CDS
      CCDS46939.1
      UniProtKB/Swiss-Prot
      Q29RV9, Q4KWH8, Q4KWH9, Q68CN0, Q86XK4, Q9H9U2, Q9UPT3
      Related
      ENSP00000345988.7, ENST00000340059.11
      Conserved Domains (8) summary
      cd00275
      Location:731855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:298701
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:227872
      PLN02228; Phosphoinositide phospholipase C
      cd00051
      Location:146212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:227298
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:147208
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:441542
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:22128
      PH-like; Pleckstrin homology-like domain
    2. NM_001130961.2NP_001124433.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform c

      See identical proteins and their annotated locations for NP_001124433.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 4, encodes isoform c.
      Source sequence(s)
      AC012022, AC132006, AK096620, AY691170, BC113950, DA206803
      Consensus CDS
      CCDS46940.1
      UniProtKB/Swiss-Prot
      Q4KWH8
      Related
      ENSP00000402759.2, ENST00000447496.6
      Conserved Domains (4) summary
      cd08632
      Location:298701
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:146286
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:22128
      PH-like; Pleckstrin homology-like domain
      cl27705
      Location:273841
      PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
    3. NM_001349250.2NP_001336179.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 3, encodes isoform c.
      Source sequence(s)
      AC012022, AC132006
      Consensus CDS
      CCDS46940.1
      Related
      ENSP00000419100.1, ENST00000494598.5
      Conserved Domains (4) summary
      cd08632
      Location:298701
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:146286
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:22128
      PH-like; Pleckstrin homology-like domain
      cl27705
      Location:273841
      PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
    4. NM_001349251.2NP_001336180.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes isoform d.
      Source sequence(s)
      AC012022, AC104472, AC132006
      Conserved Domains (4) summary
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
      cl27705
      Location:285853
      PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
    5. NM_001349252.2NP_001336181.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) encodes isoform e.
      Source sequence(s)
      AC012022, AC104472, AC132006
      Conserved Domains (4) summary
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
      cl27705
      Location:285853
      PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
    6. NM_014996.4NP_055811.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes isoform b.
      Source sequence(s)
      AC012022, AC104472, AC132006
      Consensus CDS
      CCDS33881.2
      UniProtKB/TrEMBL
      A0A2U3TZV8
      Related
      ENSP00000417502.2, ENST00000460012.7
      Conserved Domains (4) summary
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
      cl27705
      Location:285853
      PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      155450934..155745071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005927.2XP_016861416.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9

    2. XM_047447747.1XP_047303703.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8

    3. XM_047447746.1XP_047303702.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

    4. XM_047447745.1XP_047303701.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4

    5. XM_017005925.2XP_016861414.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

    6. XM_017005923.2XP_016861412.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

    7. XM_005247238.2XP_005247295.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_005247295.1

      Conserved Domains (8) summary
      cd00275
      Location:743867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:239884
      PLN02228; Phosphoinositide phospholipase C
      cd00051
      Location:158224
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:239310
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:159220
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:453554
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    8. XM_011512562.4XP_011510864.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_011510864.1

      Conserved Domains (8) summary
      cd00275
      Location:743867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:239884
      PLN02228; Phosphoinositide phospholipase C
      cd00051
      Location:158224
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:239310
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:159220
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:453554
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    9. XM_011512560.4XP_011510862.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_011510862.1

      Conserved Domains (8) summary
      cd00275
      Location:743867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:239884
      PLN02228; Phosphoinositide phospholipase C
      cd00051
      Location:158224
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:239310
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:159220
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:453554
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    10. XM_011512561.3XP_011510863.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_011510863.1

      Conserved Domains (8) summary
      cd00275
      Location:743867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:239884
      PLN02228; Phosphoinositide phospholipase C
      cd00051
      Location:158224
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:239310
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:159220
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:453554
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    11. XM_005247239.2XP_005247296.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

      Conserved Domains (7) summary
      cd00275
      Location:731855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:298701
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd00051
      Location:146212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:227298
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:147208
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:441542
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:22128
      PH-like; Pleckstrin homology-like domain
    12. XM_011512565.3XP_011510867.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

      See identical proteins and their annotated locations for XP_011510867.1

      Conserved Domains (8) summary
      cd00275
      Location:713837
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:280683
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:209854
      PLN02228; Phosphoinositide phospholipase C
      cd00051
      Location:128194
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:209280
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:129190
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:423524
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:4110
      PH-like; Pleckstrin homology-like domain
    13. XM_011512566.3XP_011510868.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

      See identical proteins and their annotated locations for XP_011510868.1

      Conserved Domains (8) summary
      cd00275
      Location:713837
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:280683
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:209854
      PLN02228; Phosphoinositide phospholipase C
      cd00051
      Location:128194
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:209280
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:129190
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:423524
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:4110
      PH-like; Pleckstrin homology-like domain
    14. XM_017005926.1XP_016861415.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

      Conserved Domains (8) summary
      cd00275
      Location:713837
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:280683
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:209854
      PLN02228; Phosphoinositide phospholipase C
      cd00051
      Location:128194
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:209280
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:129190
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:423524
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:4110
      PH-like; Pleckstrin homology-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      158220392..158518944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345751.1XP_054201726.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9

    2. XM_054345750.1XP_054201725.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8

    3. XM_054345749.1XP_054201724.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

    4. XM_054345744.1XP_054201719.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4

    5. XM_054345743.1XP_054201718.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

    6. XM_054345742.1XP_054201717.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

    7. XM_054345738.1XP_054201713.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    8. XM_054345741.1XP_054201716.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    9. XM_054345739.1XP_054201714.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    10. XM_054345740.1XP_054201715.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    11. XM_054345748.1XP_054201723.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

    12. XM_054345746.1XP_054201721.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    13. XM_054345747.1XP_054201722.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    14. XM_054345745.1XP_054201720.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5