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    IGSF9B immunoglobulin superfamily member 9B [ Homo sapiens (human) ]

    Gene ID: 22997, updated on 17-Jun-2024

    Summary

    Official Symbol
    IGSF9Bprovided by HGNC
    Official Full Name
    immunoglobulin superfamily member 9Bprovided by HGNC
    Primary source
    HGNC:HGNC:32326
    See related
    Ensembl:ENSG00000080854 MIM:613773; AllianceGenome:HGNC:32326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC00947; MIR4697HG
    Summary
    Predicted to enable kinase binding activity. Predicted to be involved in synaptic membrane adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules and positive regulation of inhibitory postsynaptic potential. Predicted to be located in dendrite; inhibitory synapse; and neuronal cell body. Predicted to be active in GABA-ergic synapse; neuron projection; and postsynaptic specialization of symmetric synapse. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 1.7), testis (RPKM 1.1) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IGSF9B in Genome Data Viewer
    Location:
    11q25
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (133896438..133956968, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (133938732..133999751, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (133766333..133826863, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133712096-133712638 Neighboring gene spermatogenesis associated 19 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:133724195-133725394 Neighboring gene calponin 2 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133764343-133765238 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133765239-133766134 Neighboring gene microRNA 4697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133800389-133801061 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133804210-133804968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133804969-133805727 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133809401-133810123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133810124-133810845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133814904-133815632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133816362-133817090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5767 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133821059-133821802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133821803-133822546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133863530-133864030 Neighboring gene long intergenic non-protein coding RNA 2730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133890717-133891220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133894031-133894833 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:133896267-133896838 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:133896839-133897409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133901031-133901530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133902231-133902958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133902959-133903686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133906753-133907724 Neighboring gene long intergenic non-protein coding RNA 2731

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ41855, KIAA1030, MGC117185, MGC126740, DKFZp434N079, DKFZp686C19121

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein turtle homolog B
    Names
    MIR4697 host gene (non-protein coding)
    long intergenic non-protein coding RNA 947
    turtle homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277285.4NP_001264214.1  protein turtle homolog B precursor

      Status: VALIDATED

      Source sequence(s)
      AP000911, AP001979
      Consensus CDS
      CCDS61010.1
      UniProtKB/Swiss-Prot
      G5EA26, Q9UPX0
      Related
      ENSP00000436552.2, ENST00000533871.8
      Conserved Domains (6) summary
      cd00096
      Location:41115
      Ig; Immunoglobulin domain
      smart00408
      Location:153210
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:426505
      IG_like; Immunoglobulin like
      cd00063
      Location:510601
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:139225
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:442505
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      133896438..133956968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      133938732..133999751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001873.3: Suppressed sequence

      Description
      NM_001001873.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    2. NM_014987.1: Suppressed sequence

      Description
      NM_014987.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to be partial on the 3' end.