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    Gtf2b general transcription factor IIB [ Mus musculus (house mouse) ]

    Gene ID: 229906, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gtf2bprovided by MGI
    Official Full Name
    general transcription factor IIBprovided by MGI
    Primary source
    MGI:MGI:2385191
    See related
    Ensembl:ENSMUSG00000028271
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in placenta adult (RPKM 50.6), liver E18 (RPKM 42.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gtf2b in Genome Data Viewer
    Location:
    3; 3 H1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142471008..142489367)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142765247..142783606)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (142428211..142446570)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene human immunodeficiency virus type I enhancer binding protein 1 pseudogene Neighboring gene kynurenine aminotransferase 3 Neighboring gene predicted gene, 24457 Neighboring gene predicted gene, 25965 Neighboring gene protein kinase N2 Neighboring gene RIKEN cDNA 9530052C20 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6859

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II core promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA-templated transcription, initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in RNA polymerase II core complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in RNA polymerase II core complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of core promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription initiation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transcription initiation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcriptional start site selection at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transcriptional start site selection at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription initiation factor IIB
    Names
    RNA polymerase II alpha initiation factor
    general transcription factor TFIIB
    NP_663521.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145546.1NP_663521.1  transcription initiation factor IIB

      See identical proteins and their annotated locations for NP_663521.1

      Status: PROVISIONAL

      Source sequence(s)
      BC016637
      Consensus CDS
      CCDS17882.1
      UniProtKB/Swiss-Prot
      P62915
      UniProtKB/TrEMBL
      Q3ULN2
      Related
      ENSMUSP00000029938.9, ENSMUST00000029938.10
      Conserved Domains (1) summary
      COG1405
      Location:14290
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      142471008..142489367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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