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    Cenpe centromere protein E [ Mus musculus (house mouse) ]

    Gene ID: 229841, updated on 5-Feb-2019

    Summary

    Official Symbol
    Cenpeprovided by MGI
    Official Full Name
    centromere protein Eprovided by MGI
    Primary source
    MGI:MGI:1098230
    See related
    Ensembl:ENSMUSG00000045328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kif10; 312kDa; CENP-E; AU019344; BC049989; C530022J18
    Expression
    Biased expression in CNS E11.5 (RPKM 11.9), liver E14 (RPKM 8.2) and 9 other tissues See more
    Orthologs

    Genomic context

    See Cenpe in Genome Data Viewer
    Location:
    3 G3; 3 62.55 cM
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (135212537..135273540)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (134875527..134936504)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 2 pseudogene Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene predicted gene, 46826 Neighboring gene 3-hydroxybutyrate dehydrogenase, type 2 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinetochore binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    attachment of spindle microtubules to kinetochore TAS
    Traceable Author Statement
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
     
    lateral attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule plus-end directed mitotic chromosome migration ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic chromosome movement towards spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic metaphase plate congression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of developmental process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    condensed chromosome outer kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    condensed nuclear chromosome kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    centromere-associated protein E
    Names
    KIF10
    N-7 kinesin
    cenpe
    centromere autoantigen E
    centromeric protein E
    kinesin 10
    kinesin superfamily protein 10
    motor domain of KIF10

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173762.4NP_776123.3  centromere-associated protein E

      Status: VALIDATED

      Source sequence(s)
      AC104874, AK133445, AY493378, CN534554, CN704540
      Consensus CDS
      CCDS51072.1
      UniProtKB/Swiss-Prot
      Q6RT24
      UniProtKB/TrEMBL
      E9QKK1
      Related
      ENSMUSP00000057938.7, ENSMUST00000062893.11
      Conserved Domains (6) summary
      pfam05483
      Location:11001841
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00129
      Location:6336
      KISc; Kinesin motor, catalytic domain. ATPase
      COG0419
      Location:15702128
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02168
      Location:5861436
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01374
      Location:6329
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam06156
      Location:10411119
      DUF972; Protein of unknown function (DUF972)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      135212537..135273540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319565.1XP_017175054.1  centromere-associated protein E isoform X1

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