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    Prune1 prune exopolyphosphatase [ Mus musculus (house mouse) ]

    Gene ID: 229589, updated on 22-Aug-2021

    Summary

    Official Symbol
    Prune1provided by MGI
    Official Full Name
    prune exopolyphosphataseprovided by MGI
    Primary source
    MGI:MGI:1925152
    See related
    Ensembl:ENSMUSG00000015711
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pr; Prune; HTCD37; DRES-17; PRUNEM1; Prune-M1; C130058A12; 9230112O05Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 23.6), whole brain E14.5 (RPKM 20.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Prune1 in Genome Data Viewer
    Location:
    3; 3 F2.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95160985..95190817, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95253674..95283506, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (95057596..95085998, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2 Neighboring gene SET domain, bifurcated 1 Neighboring gene predicted gene, 37500

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables exopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inorganic diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    exopolyphosphatase PRUNE1
    Names
    protein prune homolog
    prune homolog
    NP_775482.1
    XP_030108440.1
    XP_036018950.1
    XP_036018951.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173347.2NP_775482.1  exopolyphosphatase PRUNE1

      See identical proteins and their annotated locations for NP_775482.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057546
      Consensus CDS
      CCDS17610.1
      UniProtKB/Swiss-Prot
      Q8BIW1
      Related
      ENSMUSP00000015855.8, ENSMUST00000015855.8
      Conserved Domains (2) summary
      COG1227
      Location:21286
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:218357
      DHHA2; DHHA2 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95160985..95190817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252580.1XP_030108440.1  exopolyphosphatase PRUNE1 isoform X2

      Conserved Domains (2) summary
      COG1227
      Location:3255
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:187327
      DHHA2; DHHA2 domain
    2. XM_036163058.1XP_036018951.1  exopolyphosphatase PRUNE1 isoform X2

      Conserved Domains (2) summary
      COG1227
      Location:3255
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:187327
      DHHA2; DHHA2 domain
    3. XM_036163057.1XP_036018950.1  exopolyphosphatase PRUNE1 isoform X1

      Conserved Domains (2) summary
      COG1227
      Location:9274
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:206346
      DHHA2; DHHA2 domain
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