Format

Send to:

Choose Destination
    • Showing Current items.

    TRIM32 tripartite motif containing 32 [ Homo sapiens (human) ]

    Gene ID: 22954, updated on 9-Jul-2021

    Summary

    Official Symbol
    TRIM32provided by HGNC
    Official Full Name
    tripartite motif containing 32provided by HGNC
    Primary source
    HGNC:HGNC:16380
    See related
    Ensembl:ENSG00000119401 MIM:602290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HT2A; BBS11; TATIP; LGMD2H; LGMDR8
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 1.6), adrenal (RPKM 1.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIM32 in Genome Data Viewer
    Location:
    9q33.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (116687305..116701299)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (119449584..119463578)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene astrotactin 2 Neighboring gene uncharacterized LOC107987015 Neighboring gene uncharacterized LOC105376240 Neighboring gene uncharacterized LOC105376239 Neighboring gene uncharacterized LOC105376238

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat expression upregulates TRIM32 expression driving proliferation arrest in human neuronal precursor cells PubMed
    tat HIV-1 Tat relocalizes TRIM32 into the nucleus of human neural precursor cells, which causes an increase in ubiquitination of c-Myc PubMed
    tat HT2A specifically and precisely binds to the activation domain of HIV-1 Tat (amino acids 1-48), suggesting a role for HT2A in mediating the biological activity of Tat during HIV-1 replication PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Tat protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables myosin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein self-association IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation initiation factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in muscle cell cellular homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fibroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral release from host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of chemokine (C-C motif) ligand 20 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-17-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to tumor necrosis factor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tissue homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with striated muscle myosin thick filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM32
    Names
    72 kDa Tat-interacting protein
    RING-type E3 ubiquitin transferase TRIM32
    TAT-interactive protein, 72-KD
    tripartite motif-containing protein 32
    zinc-finger protein HT2A
    NP_001093149.1
    NP_001365977.1
    NP_001365978.1
    NP_001365979.1
    NP_036342.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011619.1 RefSeqGene

      Range
      5001..18999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_211

    mRNA and Protein(s)

    1. NM_001099679.2NP_001093149.1  E3 ubiquitin-protein ligase TRIM32

      See identical proteins and their annotated locations for NP_001093149.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL133284, BC003154, BI544919, BX091494
      Consensus CDS
      CCDS6817.1
      UniProtKB/Swiss-Prot
      Q13049
      UniProtKB/TrEMBL
      A0A024R843
      Related
      ENSP00000363095.1, ENST00000373983.2
      Conserved Domains (4) summary
      cd14961
      Location:362644
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:1965
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:98138
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      pfam15665
      Location:143224
      FAM184; Family with sequence similarity 184, A and B
    2. NM_001379048.1NP_001365977.1  E3 ubiquitin-protein ligase TRIM32

      Status: REVIEWED

      Source sequence(s)
      AL133284
      Conserved Domains (4) summary
      cd14961
      Location:362644
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:1965
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:98138
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      pfam15665
      Location:143224
      FAM184; Family with sequence similarity 184, A and B
    3. NM_001379049.1NP_001365978.1  E3 ubiquitin-protein ligase TRIM32

      Status: REVIEWED

      Source sequence(s)
      AL133284
      Conserved Domains (4) summary
      cd14961
      Location:362644
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:1965
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:98138
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      pfam15665
      Location:143224
      FAM184; Family with sequence similarity 184, A and B
    4. NM_001379050.1NP_001365979.1  E3 ubiquitin-protein ligase TRIM32

      Status: REVIEWED

      Source sequence(s)
      AL133284
      Conserved Domains (4) summary
      cd14961
      Location:362644
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:1965
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:98138
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      pfam15665
      Location:143224
      FAM184; Family with sequence similarity 184, A and B
    5. NM_012210.4NP_036342.2  E3 ubiquitin-protein ligase TRIM32

      See identical proteins and their annotated locations for NP_036342.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL133284
      Consensus CDS
      CCDS6817.1
      UniProtKB/Swiss-Prot
      Q13049
      UniProtKB/TrEMBL
      A0A024R843
      Related
      ENSP00000408292.1, ENST00000450136.2
      Conserved Domains (4) summary
      cd14961
      Location:362644
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:1965
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:98138
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      pfam15665
      Location:143224
      FAM184; Family with sequence similarity 184, A and B

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      116687305..116701299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center