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    Syt11 synaptotagmin XI [ Mus musculus (house mouse) ]

    Gene ID: 229521, updated on 27-Nov-2024

    Summary

    Official Symbol
    Syt11provided by MGI
    Official Full Name
    synaptotagmin XIprovided by MGI
    Primary source
    MGI:MGI:1859547
    See related
    Ensembl:ENSMUSG00000068923 AllianceGenome:MGI:1859547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500004A13Rik; 3632445O20Rik; 5430404N14Rik; 6530420C11Rik
    Summary
    Enables several functions, including SNARE binding activity; beta-tubulin binding activity; and identical protein binding activity. Involved in several processes, including learning or memory; negative regulation of cytokine production; and regulation of endocytosis. Located in several cellular components, including cytoplasmic vesicle; postsynaptic density; and trans-Golgi network. Is active in dopaminergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SYT11 (synaptotagmin 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 100.4), cerebellum adult (RPKM 98.9) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Syt11 in Genome Data Viewer
    Location:
    3 F1; 3 38.96 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88652006..88682466, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88744699..88775159, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2669 Neighboring gene STARR-seq mESC enhancer starr_08216 Neighboring gene Ras-like without CAAX 1 Neighboring gene predicted gene 10253 Neighboring gene STARR-positive B cell enhancer ABC_E4551 Neighboring gene gon-4-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3444 Neighboring gene STARR-seq mESC enhancer starr_08218 Neighboring gene RIKEN cDNA 1500004A13 gene Neighboring gene STARR-seq mESC enhancer starr_08219 Neighboring gene STARR-positive B cell enhancer ABC_E10195 Neighboring gene STARR-seq mESC enhancer starr_08220 Neighboring gene gon-4 like Neighboring gene predicted gene, 23054

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-tubulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT enables calcium-dependent phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion regulated lysosome exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of vesicle localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of dopamine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of membrane invagination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microglial cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plasma membrane repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to phagocytic vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of phagosome maturation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of phagosome maturation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dopaminergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dopaminergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in early phagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in inhibitory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic cup IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    synaptotagmin-11
    Names
    sytXI

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018804.3NP_061274.2  synaptotagmin-11

      See identical proteins and their annotated locations for NP_061274.2

      Status: VALIDATED

      Source sequence(s)
      BC054526, BU056967, BY295190, CD776044, CV561059
      Consensus CDS
      CCDS38484.1
      UniProtKB/Swiss-Prot
      Q7TQG8, Q9R0N3
      UniProtKB/TrEMBL
      Q3TYC4
      Related
      ENSMUSP00000088464.5, ENSMUST00000090945.5
      Conserved Domains (2) summary
      cd08388
      Location:157282
      C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
      cd08404
      Location:291428
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88652006..88682466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501350.4XP_006501413.1  synaptotagmin-11 isoform X2

      See identical proteins and their annotated locations for XP_006501413.1

      UniProtKB/TrEMBL
      Q3TPH5, Q3TYC4
      Conserved Domains (2) summary
      cd08388
      Location:157282
      C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
      cd08404
      Location:291427
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
    2. XM_006501348.1XP_006501411.1  synaptotagmin-11 isoform X1

      See identical proteins and their annotated locations for XP_006501411.1

      UniProtKB/Swiss-Prot
      Q7TQG8, Q9R0N3
      UniProtKB/TrEMBL
      Q3TYC4
      Related
      ENSMUSP00000103129.2, ENSMUST00000107505.8
      Conserved Domains (2) summary
      cd08388
      Location:157282
      C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
      cd08404
      Location:291428
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
    3. XM_030252576.1XP_030108436.1  synaptotagmin-11 isoform X1

      UniProtKB/Swiss-Prot
      Q7TQG8, Q9R0N3
      UniProtKB/TrEMBL
      Q3TYC4
      Conserved Domains (2) summary
      cd08388
      Location:157282
      C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
      cd08404
      Location:291428
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
    4. XM_036163052.1XP_036018945.1  synaptotagmin-11 isoform X2

      UniProtKB/TrEMBL
      Q3TPH5, Q3TYC4
      Related
      ENSMUSP00000138284.2, ENSMUST00000183267.2
      Conserved Domains (2) summary
      cd08388
      Location:157282
      C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
      cd08404
      Location:291427
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4