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    Eif2a eukaryotic translation initiation factor 2A [ Mus musculus (house mouse) ]

    Gene ID: 229317, updated on 5-Jul-2025
    Official Symbol
    Eif2aprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2Aprovided by MGI
    Primary source
    MGI:MGI:1098684
    See related
    Ensembl:ENSMUSG00000027810 AllianceGenome:MGI:1098684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030048D22; D3Ertd194e
    Summary
    Predicted to enable RNA binding activity; ribosome binding activity; and translation initiation factor activity. Acts upstream of or within several processes, including SREBP signaling pathway; protein phosphorylation; and regulation of signal transduction. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2 complex. Is expressed in several structures, including brain; heart; lens; liver; and ovary. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Jul 2025]
    Expression
    Broad expression in adrenal adult (RPKM 100.7), duodenum adult (RPKM 76.7) and 18 other tissues See more
    Orthologs
    NEW
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    See Eif2a in Genome Data Viewer
    Location:
    3 D; 3 28.58 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (58433252..58464922)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (58525821..58557501)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11710 Neighboring gene predicted gene, 20128 Neighboring gene TSC22 domain family, member 2 Neighboring gene STARR-seq mESC enhancer starr_07749 Neighboring gene STARR-positive B cell enhancer ABC_E1618 Neighboring gene STARR-positive B cell enhancer ABC_E516 Neighboring gene STARR-positive B cell enhancer ABC_E3433 Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene STARR-seq mESC enhancer starr_07753 Neighboring gene STARR-seq mESC enhancer starr_07754 Neighboring gene STARR-positive B cell enhancer ABC_E9549 Neighboring gene selenoprotein T Neighboring gene glutamate rich 6 Neighboring gene predicted gene, 46806

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • MGC105246

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within SREBP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endoplasmic reticulum unfolded protein response TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of ERAD pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of eukaryotic translation initiation factor 2 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic translation initiation factor 2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    eukaryotic translation initiation factor 2A
    Names
    eIF-2A

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005509.3NP_001005509.1  eukaryotic translation initiation factor 2A isoform 1

      See identical proteins and their annotated locations for NP_001005509.1

      Status: VALIDATED

      Source sequence(s)
      AC119873, AC121794
      Consensus CDS
      CCDS17367.1
      UniProtKB/Swiss-Prot
      Q05C11, Q640P8, Q8BJW6
      Related
      ENSMUSP00000029387.9, ENSMUST00000029387.15
      Conserved Domains (2) summary
      pfam08662
      Location:216411
      eIF2A; Eukaryotic translation initiation factor eIF2A
      cl02567
      Location:41143
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001411292.1NP_001398221.1  eukaryotic translation initiation factor 2A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119873, AC121794
    3. NM_001411293.1NP_001398222.1  eukaryotic translation initiation factor 2A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119873, AC121794

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      58433252..58464922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501321.5XP_006501384.1  eukaryotic translation initiation factor 2A isoform X1

      See identical proteins and their annotated locations for XP_006501384.1

      Conserved Domains (2) summary
      COG5354
      Location:36508
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      pfam08662
      Location:157352
      eIF2A; Eukaryotic translation initiation factor eIF2A
    2. XM_036163037.1XP_036018930.1  eukaryotic translation initiation factor 2A isoform X2

      Conserved Domains (2) summary
      COG5354
      Location:22454
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      pfam08662
      Location:103298
      eIF2A; Eukaryotic translation initiation factor eIF2A