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    Eif2a eukaryotic translation initiation factor 2A [ Mus musculus (house mouse) ]

    Gene ID: 229317, updated on 19-Mar-2019

    Summary

    Official Symbol
    Eif2aprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2Aprovided by MGI
    Primary source
    MGI:MGI:1098684
    See related
    Ensembl:ENSMUSG00000027810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030048D22; D3Ertd194e
    Expression
    Broad expression in adrenal adult (RPKM 100.7), duodenum adult (RPKM 76.7) and 18 other tissues See more
    Orthologs

    Genomic context

    See Eif2a in Genome Data Viewer
    Location:
    3 D; 3 28.58 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (58525821..58557501)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (58329743..58361423)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 20128 Neighboring gene TSC22 domain family, member 2 Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene selenoprotein T Neighboring gene glutamate rich 6 Neighboring gene predicted gene, 46806

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC105246

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    SREBP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic translation initiation factor 2 complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2A
    Names
    eIF-2A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005509.2NP_001005509.1  eukaryotic translation initiation factor 2A

      See identical proteins and their annotated locations for NP_001005509.1

      Status: VALIDATED

      Source sequence(s)
      BC082557, BY035972
      Consensus CDS
      CCDS17367.1
      UniProtKB/Swiss-Prot
      Q8BJW6
      Related
      ENSMUSP00000029387.8, ENSMUST00000029387.14
      Conserved Domains (2) summary
      pfam08662
      Location:216411
      eIF2A; Eukaryotic translation initiation factor eIF2A
      cl02567
      Location:41143
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      58525821..58557501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501321.3XP_006501384.1  eukaryotic translation initiation factor 2A isoform X1

      See identical proteins and their annotated locations for XP_006501384.1

      Conserved Domains (1) summary
      pfam08662
      Location:157352
      eIF2A; Eukaryotic translation initiation factor eIF2A
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