Eif2a eukaryotic translation initiation factor 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif2aprovided by MGI
Official Full Name: eukaryotic translation initiation factor 2Aprovided by MGI
Primary source: MGI:MGI:1098684
See related: Ensembl:ENSMUSG00000027810 AllianceGenome:MGI:1098684
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D030048D22; D3Ertd194e
Summary: Predicted to enable RNA binding activity and ribosome binding activity. Acts upstream of or within SREBP signaling pathway; cellular protein metabolic process; and positive regulation of signal transduction. Predicted to be located in cytoplasm. Predicted to be part of cytosolic small ribosomal subunit and eukaryotic translation initiation factor 2 complex. Is expressed in brain; early conceptus; lens; liver; and ovary. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 100.7), duodenum adult (RPKM 76.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 D; 3 28.58 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (58433242..58464922)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (58525821..58557501)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2alpha/ATF4/CHOP pathway in vitro.
Title: Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro.
eIF2alphaP is a nodal point of mTORC1 signaling, which can determine the susceptibility of TSC2-deficient cells to oxidative insults and their efficacy in tumor formation in mice maintained on antioxidant diet.
Title: Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.
phosphorylation of eIF2alpha was mediated via protein kinase R (PKR), but further investigation revealed that PKR activation, phosphorylation of eIF2alpha, and translational arrest were uncoupled during viral infection
Title: Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis.
CReP deletion activates a linear signaling pathway involving eIF2alpha phosphorylation, ATF4 translation, and FGF21 induction, which promotes increased energy expenditure, and subsequently improved obesity-related metabolic parameters.
Title: Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction.
The data show that activating transcription factor 4 is not required, but eukaryotic initiation factor 2 alpha phosphorylation is necessary to prevent mTORC1 activation during amino acid stress.
Title: Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation.
Title: HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α ubiquitylation and degradation.
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha-CHOP and activation of XBP-1 in RGC specifically, protects RGC somata and axons and preserves visual function.
Title: Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss.
alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP activation, and enhanced macrophage beclin1 dependent autophagy.
Title: α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy.
In response to endoplasmic reticulum stress, activation of PERK coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis.
Title: Dual role of the integrated stress response in medulloblastoma tumorigenesis.
stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages.
Title: Importance of eIF2α phosphorylation as a protective mechanism against heat stress in mouse male germ cells.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126411 (e-PCR)
- UniSTS:163119

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

BB254882 (e-PCR)
- UniSTS:207493

Homology

Homologs of the Eif2a gene: The Eif2a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 447 organisms have orthologs with human gene Eif2a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within SREBP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in ribosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within translation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of eukaryotic translation initiation factor 2 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 2A

Names: eIF-2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005509.3 → NP_001005509.1 eukaryotic translation initiation factor 2A isoform 1

See identical proteins and their annotated locations for NP_001005509.1

Status: VALIDATED

Source sequence(s)

AC119873, AC121794

Consensus CDS

CCDS17367.1

UniProtKB/Swiss-Prot

Q640P8, Q8BJW6

Related

ENSMUSP00000029387.9, ENSMUST00000029387.15

Conserved Domains (2) summary

pfam08662
Location:216 → 411

eIF2A; Eukaryotic translation initiation factor eIF2A

cl02567
Location:41 → 143

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001411292.1 → NP_001398221.1 eukaryotic translation initiation factor 2A isoform 2

Status: VALIDATED

Source sequence(s)

AC119873, AC121794
NM_001411293.1 → NP_001398222.1 eukaryotic translation initiation factor 2A isoform 3

Status: VALIDATED

Source sequence(s)

AC119873, AC121794

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

58433242..58464922

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501321.5 → XP_006501384.1 eukaryotic translation initiation factor 2A isoform X1

See identical proteins and their annotated locations for XP_006501384.1

Conserved Domains (2) summary

COG5354
Location:36 → 508

COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]

pfam08662
Location:157 → 352

eIF2A; Eukaryotic translation initiation factor eIF2A
XM_036163037.1 → XP_036018930.1 eukaryotic translation initiation factor 2A isoform X2

Conserved Domains (2) summary

COG5354
Location:22 → 454

COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]

pfam08662
Location:103 → 298

eIF2A; Eukaryotic translation initiation factor eIF2A