Eif2a eukaryotic translation initiation factor 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif2aprovided by MGI
Official Full Name: eukaryotic translation initiation factor 2Aprovided by MGI
Primary source: MGI:MGI:1098684
See related: Ensembl:ENSMUSG00000027810
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D030048D22; D3Ertd194e
Expression: Broad expression in adrenal adult (RPKM 100.7), duodenum adult (RPKM 76.7) and 18 other tissues See more
Orthologs: human all

Genomic context

Location:: 3 D; 3 28.58 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	3	NC_000069.6 (58525821..58557501)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	3	NC_000069.5 (58329743..58361423)

Chromosome 3 - NC_000069.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

The data show that activating transcription factor 4 is not required, but eukaryotic initiation factor 2 alpha phosphorylation is necessary to prevent mTORC1 activation during amino acid stress.
Title: Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation.
Title: HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α ubiquitylation and degradation.
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha-CHOP and activation of XBP-1 in RGC specifically, protects RGC somata and axons and preserves visual function.
Title: Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss.
alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP activation, and enhanced macrophage beclin1 dependent autophagy.
Title: α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy.
In response to endoplasmic reticulum stress, activation of PERK coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis.
Title: Dual role of the integrated stress response in medulloblastoma tumorigenesis.
stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages.
Title: Importance of eIF2α phosphorylation as a protective mechanism against heat stress in mouse male germ cells.
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Title: A protective role of Heme-regulated eIF2α kinase in cadmium-induced liver and kidney injuries.
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 expression. (eIF2a = eukaryotic initiation factor-2alpha; PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 = activating transcription factor 4)
Title: Hydrogen sulfide modulates eukaryotic translation initiation factor 2α (eIF2α) phosphorylation status in the integrated stress-response pathway.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
Title: Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for Dystonia.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Title: The eIF2A knockout mouse.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

Pathways from BioSystems

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IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 signaling Pathway, organism-specific biosystem
IL-6 signaling Pathway

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126411 (e-PCR)
- UniSTS:163119

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

BB254882 (e-PCR)
- UniSTS:207493

Homology

Homologs of the Eif2a gene: The Eif2a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 265 organisms have orthologs with human gene Eif2a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ribosome binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ribosome binding	ISO Inferred from Sequence Orthology more info
tRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
tRNA binding	ISO Inferred from Sequence Orthology more info
translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
SREBP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of translation	ISO Inferred from Sequence Orthology more info
response to amino acid starvation	ISO Inferred from Sequence Orthology more info
ribosome assembly	ISO Inferred from Sequence Orthology more info
translation	IDA Inferred from Direct Assay more info	PubMed
translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info	PubMed
eukaryotic translation initiation factor 2 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 2A

Names: eIF-2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005509.2 → NP_001005509.1 eukaryotic translation initiation factor 2A

See identical proteins and their annotated locations for NP_001005509.1

Status: VALIDATED

Source sequence(s)

BC082557, BY035972

Consensus CDS

CCDS17367.1

UniProtKB/Swiss-Prot

Q8BJW6

Related

ENSMUSP00000029387.8, ENSMUST00000029387.14

Conserved Domains (2) summary

pfam08662
Location:216 → 411

eIF2A; Eukaryotic translation initiation factor eIF2A

cl02567
Location:41 → 143

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...