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    DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [ Homo sapiens (human) ]

    Gene ID: 22894, updated on 11-Apr-2024

    Summary

    Official Symbol
    DIS3provided by HGNC
    Official Full Name
    DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by HGNC
    Primary source
    HGNC:HGNC:20604
    See related
    Ensembl:ENSG00000083520 MIM:607533; AllianceGenome:HGNC:20604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik
    Summary
    Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 10.1), lymph node (RPKM 7.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DIS3 in Genome Data Viewer
    Location:
    13q21.33
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (72752169..72781900, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (71973643..72003383, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (73326307..73356038, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 80, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73301228-73301409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7814 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene BORA aurora kinase A activator Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:73355230-73356144 Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73426017-73426548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:73426549-73427078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7816 Neighboring gene RNA, U6 small nuclear 79, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73509249-73509443 Neighboring gene NANOG hESC enhancer GRCh37_chr13:73534622-73535123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73610339-73611015 Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10484, MGC33035, DKFZp667L1817

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5'-RNA exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables 3'-5'-RNA exonuclease activity TAS
    Traceable Author Statement
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in CUT catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nuclear mRNA surveillance of mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS
    Traceable Author Statement
    more info
     
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of exosome (RNase complex) TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane HDA PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    exosome complex exonuclease RRP44
    Names
    DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
    DIS3 mitotic control homolog
    exosome component 11
    mitotic control protein dis3 homolog
    ribosomal RNA-processing protein 44

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128226.3NP_001121698.1  exosome complex exonuclease RRP44 isoform b

      See identical proteins and their annotated locations for NP_001121698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AB023225, AL080158, AL138695, AL832266, U79246
      Consensus CDS
      CCDS45057.1
      UniProtKB/TrEMBL
      A8QI98
      Related
      ENSP00000367011.4, ENST00000377780.8
      Conserved Domains (3) summary
      COG0557
      Location:192900
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:437765
      RNB; RNB domain
      cl14812
      Location:9167
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    2. NM_001322348.2NP_001309277.1  exosome complex exonuclease RRP44 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL138695, AL391384
      UniProtKB/TrEMBL
      Q49AG4
      Conserved Domains (3) summary
      COG0557
      Location:99807
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:344672
      RNB; RNB domain
      cl14812
      Location:674
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    3. NM_001322349.2NP_001309278.1  exosome complex exonuclease RRP44 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL138695, AL391384
      Consensus CDS
      CCDS81772.1
      UniProtKB/TrEMBL
      G3V1J5, Q49AG4
      Related
      ENSP00000440058.1, ENST00000545453.5
      Conserved Domains (3) summary
      COG0557
      Location:60768
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:305633
      RNB; RNB domain
      cl14812
      Location:335
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    4. NM_014953.5NP_055768.3  exosome complex exonuclease RRP44 isoform a

      See identical proteins and their annotated locations for NP_055768.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL080158, AL138695, AL832266, BC056143, U79246
      Consensus CDS
      CCDS9447.1
      UniProtKB/Swiss-Prot
      A6NI21, B2RBL2, Q5W0P7, Q5W0P8, Q658Z7, Q7Z481, Q8WWI2, Q9UG36, Q9Y2L1
      UniProtKB/TrEMBL
      A8QI98
      Related
      ENSP00000366997.4, ENST00000377767.9
      Conserved Domains (3) summary
      cd09862
      Location:9197
      PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
      COG0557
      Location:222930
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:467795
      RNB; RNB domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      72752169..72781900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      71973643..72003383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)